Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894670618> ?p ?o ?g. }
- W2894670618 endingPage "241" @default.
- W2894670618 startingPage "241" @default.
- W2894670618 abstract "Ovarian cancer is the most lethal gynecological malignancy. Poor overall survival, particularly for patients with high grade serous (HGS) ovarian cancer, is often attributed to late stage at diagnosis and relapse following chemotherapy. HGS ovarian cancer is a heterogenous disease in that few genes are consistently mutated between patients. Additionally, HGS ovarian cancer is characterized by high genomic instability. For these reasons, personalized approaches may be necessary for effective treatment and cure. Understanding the molecular mechanisms that contribute to tumor metastasis and chemoresistance are essential to improve survival rates. One favored model for tumor metastasis and chemoresistance is the cancer stem cell (CSC) model. CSCs are cells with enhanced self-renewal properties that are enriched following chemotherapy. Elimination of this cell population is thought to be a mechanism to increase therapeutic response. Therefore, accurate identification of stem cell populations that are most clinically relevant is necessary. While many CSC identifiers (ALDH, OCT4, CD133, and side population) have been established, it is still not clear which population(s) will be most beneficial to target in patients. Therefore, there is a critical need to characterize CSCs with reliable markers and find their weaknesses that will make the CSCs amenable to therapy. Many signaling pathways are implicated for their roles in CSC initiation and maintenance. Therapeutically targeting pathways needed for CSC initiation or maintenance may be an effective way of treating HGS ovarian cancer patients. In conclusion, the prognosis for HGS ovarian cancer may be improved by combining CSC phenotyping with targeted therapies for pathways involved in CSC maintenance." @default.
- W2894670618 created "2018-10-12" @default.
- W2894670618 creator A5029164769 @default.
- W2894670618 creator A5086145770 @default.
- W2894670618 date "2018-07-24" @default.
- W2894670618 modified "2023-10-07" @default.
- W2894670618 title "Can Stemness and Chemoresistance Be Therapeutically Targeted via Signaling Pathways in Ovarian Cancer?" @default.
- W2894670618 cites W1483167997 @default.
- W2894670618 cites W1695255415 @default.
- W2894670618 cites W1739249602 @default.
- W2894670618 cites W176541616 @default.
- W2894670618 cites W1806554070 @default.
- W2894670618 cites W1813804250 @default.
- W2894670618 cites W1944446133 @default.
- W2894670618 cites W1957032643 @default.
- W2894670618 cites W1966354133 @default.
- W2894670618 cites W1967304777 @default.
- W2894670618 cites W1967979352 @default.
- W2894670618 cites W1968109047 @default.
- W2894670618 cites W1970391983 @default.
- W2894670618 cites W1970851801 @default.
- W2894670618 cites W1971085650 @default.
- W2894670618 cites W1974567048 @default.
- W2894670618 cites W1975141727 @default.
- W2894670618 cites W1976564360 @default.
- W2894670618 cites W1977342376 @default.
- W2894670618 cites W1980494624 @default.
- W2894670618 cites W1981851591 @default.
- W2894670618 cites W1985247417 @default.
- W2894670618 cites W1996737831 @default.
- W2894670618 cites W1999356404 @default.
- W2894670618 cites W2004419844 @default.
- W2894670618 cites W2012402101 @default.
- W2894670618 cites W2012582486 @default.
- W2894670618 cites W2013107316 @default.
- W2894670618 cites W2015396326 @default.
- W2894670618 cites W2017975901 @default.
- W2894670618 cites W2018360235 @default.
- W2894670618 cites W2019865561 @default.
- W2894670618 cites W2020131167 @default.
- W2894670618 cites W2020458598 @default.
- W2894670618 cites W2021958215 @default.
- W2894670618 cites W2024022439 @default.
- W2894670618 cites W2026577870 @default.
- W2894670618 cites W2026862874 @default.
- W2894670618 cites W2029150071 @default.
- W2894670618 cites W2030329983 @default.
- W2894670618 cites W2041039221 @default.
- W2894670618 cites W2050212958 @default.
- W2894670618 cites W2050394736 @default.
- W2894670618 cites W2054002500 @default.
- W2894670618 cites W2055344345 @default.
- W2894670618 cites W2057058351 @default.
- W2894670618 cites W2061451800 @default.
- W2894670618 cites W2067067209 @default.
- W2894670618 cites W2070010419 @default.
- W2894670618 cites W2073364823 @default.
- W2894670618 cites W2074982201 @default.
- W2894670618 cites W2076293231 @default.
- W2894670618 cites W2077013369 @default.
- W2894670618 cites W2077223423 @default.
- W2894670618 cites W2080336441 @default.
- W2894670618 cites W2083274861 @default.
- W2894670618 cites W2086830762 @default.
- W2894670618 cites W2089072450 @default.
- W2894670618 cites W2089477889 @default.
- W2894670618 cites W2089542415 @default.
- W2894670618 cites W2090973422 @default.
- W2894670618 cites W2092864627 @default.
- W2894670618 cites W2092999618 @default.
- W2894670618 cites W2093518370 @default.
- W2894670618 cites W2094829108 @default.
- W2894670618 cites W2096643870 @default.
- W2894670618 cites W2099225054 @default.
- W2894670618 cites W2102267947 @default.
- W2894670618 cites W2103673770 @default.
- W2894670618 cites W2105080125 @default.
- W2894670618 cites W2106439593 @default.
- W2894670618 cites W2107648723 @default.
- W2894670618 cites W2108261167 @default.
- W2894670618 cites W2110838173 @default.
- W2894670618 cites W2110994269 @default.
- W2894670618 cites W2112973598 @default.
- W2894670618 cites W2116504531 @default.
- W2894670618 cites W2117177285 @default.
- W2894670618 cites W2118667301 @default.
- W2894670618 cites W2121542859 @default.
- W2894670618 cites W2123410474 @default.
- W2894670618 cites W2124185479 @default.
- W2894670618 cites W2126712477 @default.
- W2894670618 cites W2129835104 @default.
- W2894670618 cites W2133750440 @default.
- W2894670618 cites W2134576998 @default.
- W2894670618 cites W2138784667 @default.
- W2894670618 cites W2139028067 @default.
- W2894670618 cites W2139706862 @default.
- W2894670618 cites W2140350596 @default.
- W2894670618 cites W2145447734 @default.