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- W2894678423 abstract "Abstract Environmental DNA surveys reveal that most fungal diversity represents uncultured species. We sequenced the genomes of eight uncultured species across the fungal tree of life using a new single-cell genomics pipeline. We show that, despite a large variation in genome and gene space recovery from each single amplified genome (SAG), ≥90% can be recovered by combining multiple SAGs. SAGs provide robust placement for early-diverging lineages and infer a diploid ancestor of fungi. Early-diverging fungi share metabolic deficiencies and show unique gene expansions correlated with parasitism and unculturability. Single-cell genomics holds great promise in exploring fungal diversity, life cycles and metabolic potential." @default.
- W2894678423 created "2018-10-12" @default.
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- W2894678423 date "2018-10-08" @default.
- W2894678423 modified "2023-10-14" @default.
- W2894678423 title "Leveraging single-cell genomics to expand the fungal tree of life" @default.
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