FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894686126> ?p ?o ?g. }

• W2894686126 endingPage "68A" @default.
• W2894686126 startingPage "68A" @default.
• W2894686126 abstract "SESSION TITLE: Cardiovascular Disease SESSION TYPE: Original Investigations PRESENTED ON: 10/09/2018 02:30 PM - 03:30 PM PURPOSE: The American Heart Association recommends the use of end-tidal CO2(ETCO2) as a marker of the quality of cardiopulmonary resuscitation (CPR). An ETCO2 <20 mm Hg at 20 minutes has been proposed to predict the inability to achieve return of spontaneous circulation (ROSC). However, this is based on data from out of hospital cardiac arrest (OHCA) studies, which have been extrapolated to cardiac arrests in patients already admitted to the hospital. As the in-hospital cardiac arrest (IHCA) population is inherently different to OHCA, we examined the potential utility of ETCO2 to predict ROSC in IHCA. METHODS: Setting: Retrospective data from an on-going multi-center prospective study (06/2015-07/2017) across seven centers.Inclusion criteria:Age >18 years and cardiac arrest occurring after already admitted to hospital. Exclusion criteria: OHCA. Methods: Research staff attended all IHCA during working hours (09:00-17:00) and commenced continuous ETCO2 monitoring (Nonin Medical) within 5 minutes of IHCA. Measurements: ETCO2 data were captured every second until ROSC or termination of CPR. We measured the ETCO2 thresholds of 10, 20, 25, and 40 mmHg ETCO2 at t=0 (the first recording), 10, 15, and 20 minutes into CPR, as well as the average ETCO2 throughout CPR in subjects with ROSC vs. No ROSC using a T test and Pearson’s Chi squared test. RESULTS: 88 subjects were recruited and 35 (38%) achieved ROSC. There was a significant difference in overall mean ETCO2 during CPR between ROSC vs. No ROSC groups (25.9 mm Hg± 2.0 vs. 19.7 mm Hg± 1.5 p=0.01). While achieving an ETCO2 >20 or >25 any time in the first 5 or 10 minutes of CPR was significantly associated with ROSC (all P<0.03, sensitivity >85%, specificity <40, approximate PPV=60% and NPV=70%), when these thresholds were achieved >20 minutes into CPR no association with ROSC was observed. We also examined the utility of pre-specified thresholds of ETCO2 at pre-defined time points and found no differences in ETCO2 at t=0, 15 or 20 minutes of CPR between those with ROSC vs. No ROSC. However, a significant difference was observed in the ROSC vs. No ROSC groups using an ETCO2 threshold >40mm Hg at 10 minutes (P=0.02, 23% sensitivity, 97% specificity, 93% NPV, 41% PPV). CONCLUSIONS: Different ETCO2 thresholds may apply to IHCA versus OHCA populations for the prediction of ROSC. CLINICAL IMPLICATIONS: Our data suggest that achieving higher levels of ETCO2 within the first 10 minutes of IHCA, particularly >40mmHg may be important for achieving ROSC. However, even if higher thresholds of ETCO2 are reached beyond 20 minutes of CPR, they may not contribute to ROSC. This may reflect the impact of progressively worsening ischemia during the metabolic phase of cardiac arrest (beyond 10 minutes), which leads to progressive refractoriness of this condition to treatment despite high quality CPR. Larger IHCA studies are needed to evaluate the utility of ETCO2 in this population. DISCLOSURES: No relevant relationships by Amanda Mengotto, source=Web Response No relevant relationships by Caitlin O'Neill, source=Web Response no disclosure on file for Sam Parnia; no disclosure on file for Jignesh Patel; No relevant relationships by Ying (Shelly) Qi, source=Web Response No relevant relationships by Michael Rosman, source=Web Response" @default.
• W2894686126 created "2018-10-12" @default.
• W2894686126 creator A5013847413 @default.
• W2894686126 creator A5045302820 @default.
• W2894686126 creator A5047750906 @default.
• W2894686126 creator A5054097793 @default.
• W2894686126 creator A5054183595 @default.
• W2894686126 creator A5083295306 @default.
• W2894686126 date "2018-10-01" @default.
• W2894686126 modified "2023-09-25" @default.
• W2894686126 title "THE UTILITY OF END TIDAL CO2 (ETCO2) MONITORING DURING IN-HOSPITAL CARDIAC ARREST TO PREDICT RETURN OF SPONTANEOUS CIRCULATION" @default.
• W2894686126 doi "https://doi.org/10.1016/j.chest.2018.08.062" @default.
• W2894686126 hasPublicationYear "2018" @default.
• W2894686126 type Work @default.
• W2894686126 sameAs 2894686126 @default.
• W2894686126 citedByCount "0" @default.
• W2894686126 crossrefType "journal-article" @default.
• W2894686126 hasAuthorship W2894686126A5013847413 @default.
• W2894686126 hasAuthorship W2894686126A5045302820 @default.
• W2894686126 hasAuthorship W2894686126A5047750906 @default.
• W2894686126 hasAuthorship W2894686126A5054097793 @default.
• W2894686126 hasAuthorship W2894686126A5054183595 @default.
• W2894686126 hasAuthorship W2894686126A5083295306 @default.
• W2894686126 hasConcept C118552586 @default.
• W2894686126 hasConcept C126322002 @default.
• W2894686126 hasConcept C164705383 @default.
• W2894686126 hasConcept C177713679 @default.
• W2894686126 hasConcept C194828623 @default.
• W2894686126 hasConcept C2777055891 @default.
• W2894686126 hasConcept C2778165595 @default.
• W2894686126 hasConcept C2778496132 @default.
• W2894686126 hasConcept C2778619729 @default.
• W2894686126 hasConcept C2780724011 @default.
• W2894686126 hasConcept C2908647359 @default.
• W2894686126 hasConcept C71924100 @default.
• W2894686126 hasConcept C99454951 @default.
• W2894686126 hasConceptScore W2894686126C118552586 @default.
• W2894686126 hasConceptScore W2894686126C126322002 @default.
• W2894686126 hasConceptScore W2894686126C164705383 @default.
• W2894686126 hasConceptScore W2894686126C177713679 @default.
• W2894686126 hasConceptScore W2894686126C194828623 @default.
• W2894686126 hasConceptScore W2894686126C2777055891 @default.
• W2894686126 hasConceptScore W2894686126C2778165595 @default.
• W2894686126 hasConceptScore W2894686126C2778496132 @default.
• W2894686126 hasConceptScore W2894686126C2778619729 @default.
• W2894686126 hasConceptScore W2894686126C2780724011 @default.
• W2894686126 hasConceptScore W2894686126C2908647359 @default.
• W2894686126 hasConceptScore W2894686126C71924100 @default.
• W2894686126 hasConceptScore W2894686126C99454951 @default.
• W2894686126 hasIssue "4" @default.
• W2894686126 hasLocation W28946861261 @default.
• W2894686126 hasOpenAccess W2894686126 @default.
• W2894686126 hasPrimaryLocation W28946861261 @default.
• W2894686126 hasRelatedWork W1997200831 @default.
• W2894686126 hasRelatedWork W2019494470 @default.
• W2894686126 hasRelatedWork W2095562355 @default.
• W2894686126 hasRelatedWork W2107686389 @default.
• W2894686126 hasRelatedWork W2398258065 @default.
• W2894686126 hasRelatedWork W2938229303 @default.
• W2894686126 hasRelatedWork W3100628673 @default.
• W2894686126 hasRelatedWork W3200649395 @default.
• W2894686126 hasRelatedWork W4296754942 @default.
• W2894686126 hasRelatedWork W48482181 @default.
• W2894686126 hasVolume "154" @default.
• W2894686126 isParatext "false" @default.
• W2894686126 isRetracted "false" @default.
• W2894686126 magId "2894686126" @default.
• W2894686126 workType "article" @default.