FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894688767> ?p ?o ?g. }

• W2894688767 endingPage "1675" @default.
• W2894688767 startingPage "1675" @default.
• W2894688767 abstract "Ovarian cancer is a highly fatal malignant neoplasm with few modifiable risk factors. Case-control studies have reported a modest reduced risk of ovarian cancer among women who frequently use aspirin or regularly use low-dose aspirin.To evaluate whether regular aspirin or nonaspirin nonsteroidal anti-inflammatory drug (NSAID) use and patterns of use are associated with lower ovarian cancer risk.This cohort study analyzed NSAID use and ovarian cancer diagnosis data from 2 prospective cohorts, 93 664 women in the Nurses' Health Study (NHS), who were followed up from 1980 to 2014, and 111 834 in the Nurses' Health Study II (NHSII), who were followed up from 1989 to 2015. Follow-up was completed on June 30, 2014, for the NHS and June 30, 2015, for NHSII. Data were analyzed from June 13, 2016, to September 18, 2017.For each analgesic type (aspirin, low-dose aspirin, nonaspirin NSAIDs, and acetaminophen), timing, duration, frequency, and number of tablets used were evaluated; exposure information was updated every 2 to 4 years.Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% CIs for associations of aspirin, nonaspirin NSAIDs, and acetaminophen with risk of epithelial ovarian cancer. All statistical tests were 2-sided, with a significance level of .05.In the NHS, the mean (SD) age at baseline (1980) was 45.9 (7.2) years, and 93% of participants identified as non-Hispanic white. In the NHSII, the mean age at baseline (1989) was 34.2 (4.7) years, and 92% identified as non-Hispanic white. Among the 205 498 women in both cohorts, there were 1054 cases of incident epithelial ovarian cancer. Significant associations between aspirin and ovarian cancer risk were not observed when current vs nonuse of any aspirin was evaluated regardless of dose (HR, 0.99; 95% CI, 0.83-1.19). However, when low-dose (≤100-mg) and standard-dose (325-mg) aspirin were evaluated separately, an inverse association for low-dose aspirin (HR, 0.77; 95% CI, 0.61-0.96), but no association for standard-dose aspirin (HR, 1.17; 95% CI, 0.92-1.49) was observed. Current use of nonaspirin NSAIDs was positively associated with risk of ovarian cancer compared with nonuse (HR, 1.19; 95% CI, 1.00-1.41), and significant positive trends for duration of use (P = .02 for trend) and cumulative average tablets per week (P = .03 for trend) were observed. There were no clear associations for the use of acetaminophen.These results appear to be consistent with case-control studies that show a reduced risk of ovarian cancer among regular users of low-dose aspirin. An increased risk of ovarian cancer with long-term high-quantity use of other analgesics, particularly nonaspirin NSAIDs, was observed, although this finding requires confirmation." @default.
• W2894688767 created "2018-10-12" @default.
• W2894688767 creator A5014551852 @default.
• W2894688767 creator A5051186379 @default.
• W2894688767 creator A5051731200 @default.
• W2894688767 creator A5064382326 @default.
• W2894688767 creator A5074259922 @default.
• W2894688767 creator A5078859928 @default.
• W2894688767 creator A5089191285 @default.
• W2894688767 date "2018-12-01" @default.
• W2894688767 modified "2023-10-12" @default.
• W2894688767 title "Association of Analgesic Use With Risk of Ovarian Cancer in the Nurses’ Health Studies" @default.
• W2894688767 cites W1592007606 @default.
• W2894688767 cites W1914046457 @default.
• W2894688767 cites W1965400789 @default.
• W2894688767 cites W1982026358 @default.
• W2894688767 cites W1982785558 @default.
• W2894688767 cites W1990719139 @default.
• W2894688767 cites W2001083758 @default.
• W2894688767 cites W2011941025 @default.
• W2894688767 cites W2019126030 @default.
• W2894688767 cites W2030214755 @default.
• W2894688767 cites W2036029912 @default.
• W2894688767 cites W2037182281 @default.
• W2894688767 cites W2050505846 @default.
• W2894688767 cites W2050693842 @default.
• W2894688767 cites W2073023604 @default.
• W2894688767 cites W2078211078 @default.
• W2894688767 cites W2090702820 @default.
• W2894688767 cites W2101252464 @default.
• W2894688767 cites W2102544382 @default.
• W2894688767 cites W2129276798 @default.
• W2894688767 cites W2132388756 @default.
• W2894688767 cites W2145707658 @default.
• W2894688767 cites W2145946968 @default.
• W2894688767 cites W2148976855 @default.
• W2894688767 cites W2156778593 @default.
• W2894688767 cites W2158464138 @default.
• W2894688767 cites W2161515819 @default.
• W2894688767 cites W2165234889 @default.
• W2894688767 cites W2183695321 @default.
• W2894688767 cites W2251113869 @default.
• W2894688767 cites W2262329766 @default.
• W2894688767 cites W2271002818 @default.
• W2894688767 cites W2277625479 @default.
• W2894688767 cites W2318931832 @default.
• W2894688767 cites W2379171874 @default.
• W2894688767 cites W2419477524 @default.
• W2894688767 cites W4207058970 @default.
• W2894688767 cites W4231636978 @default.
• W2894688767 cites W4240853929 @default.
• W2894688767 cites W4290217457 @default.
• W2894688767 doi "https://doi.org/10.1001/jamaoncol.2018.4149" @default.
• W2894688767 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6400245" @default.
• W2894688767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30286239" @default.
• W2894688767 hasPublicationYear "2018" @default.
• W2894688767 type Work @default.
• W2894688767 sameAs 2894688767 @default.
• W2894688767 citedByCount "42" @default.
• W2894688767 countsByYear W28946887672018 @default.
• W2894688767 countsByYear W28946887672019 @default.
• W2894688767 countsByYear W28946887672020 @default.
• W2894688767 countsByYear W28946887672021 @default.
• W2894688767 countsByYear W28946887672022 @default.
• W2894688767 countsByYear W28946887672023 @default.
• W2894688767 crossrefType "journal-article" @default.
• W2894688767 hasAuthorship W2894688767A5014551852 @default.
• W2894688767 hasAuthorship W2894688767A5051186379 @default.
• W2894688767 hasAuthorship W2894688767A5051731200 @default.
• W2894688767 hasAuthorship W2894688767A5064382326 @default.
• W2894688767 hasAuthorship W2894688767A5074259922 @default.
• W2894688767 hasAuthorship W2894688767A5078859928 @default.
• W2894688767 hasAuthorship W2894688767A5089191285 @default.
• W2894688767 hasBestOaLocation W28946887671 @default.
• W2894688767 hasConcept C121608353 @default.
• W2894688767 hasConcept C126322002 @default.
• W2894688767 hasConcept C148759681 @default.
• W2894688767 hasConcept C188816634 @default.
• W2894688767 hasConcept C201903717 @default.
• W2894688767 hasConcept C207103383 @default.
• W2894688767 hasConcept C2777628954 @default.
• W2894688767 hasConcept C2778722691 @default.
• W2894688767 hasConcept C2780427987 @default.
• W2894688767 hasConcept C2780820201 @default.
• W2894688767 hasConcept C42219234 @default.
• W2894688767 hasConcept C44249647 @default.
• W2894688767 hasConcept C71924100 @default.
• W2894688767 hasConceptScore W2894688767C121608353 @default.
• W2894688767 hasConceptScore W2894688767C126322002 @default.
• W2894688767 hasConceptScore W2894688767C148759681 @default.
• W2894688767 hasConceptScore W2894688767C188816634 @default.
• W2894688767 hasConceptScore W2894688767C201903717 @default.
• W2894688767 hasConceptScore W2894688767C207103383 @default.
• W2894688767 hasConceptScore W2894688767C2777628954 @default.
• W2894688767 hasConceptScore W2894688767C2778722691 @default.
• W2894688767 hasConceptScore W2894688767C2780427987 @default.
• W2894688767 hasConceptScore W2894688767C2780820201 @default.
• W2894688767 hasConceptScore W2894688767C42219234 @default.

• next