FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894711779> ?p ?o ?g. }

• W2894711779 endingPage "1292" @default.
• W2894711779 startingPage "1292" @default.
• W2894711779 abstract "Controversies about the choice of antibiotic agent and treatment modality exist in the management of erythema migrans in early cutaneous Lyme borreliosis (LB).To conduct a network meta-analysis (NMA) of all randomized clinical trials on various antibiotic agents and treatment modalities in early cutaneous LB.Electronic searches in MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were conducted from inception until July 2017. The reference lists of the included studies were hand searched, authors were contacted, and ongoing trials were searched at ClinicalTrials.gov.One reviewer screened the titles and abstracts of the 9975 reports identified by the electronic searches. Full-text copies of 161 potentially relevant articles were obtained, and 2 reviewers independently assessed those articles for inclusion. Adults with a physician-confirmed early localized skin infection who were treated with antibiotics of any dose or duration were included.Two reviewers independently extracted data on study, patient, and intervention characteristics. Network meta-analyses on treatment effects and adverse outcomes were calculated with a frequentist approach using the R package netmeta. The Grading of Recommendations Assessment, Development and Evaluation guidance for NMA was used to assess the certainty of evidence.Treatment effects for response to treatment (resolution of symptoms) and treatment-related adverse events.Overall, 19 studies (2532 patients) were included. The mean patient age ranged between 37 and 56 years, and the percentage of female patients ranged from 36% to 60%. The antibiotics investigated were doxycycline, cefuroxime axetil, ceftriaxone, amoxicillin, azithromycin, penicillin V, and minocycline. Pooled effect sizes from NMAs did not suggest any significant differences in treatment response by antibiotic agent (eg, amoxicillin vs doxycycline odds ratio, 1.26; 95% CI, 0.41-3.87), dose, or duration (eg, doxycycline, 200 mg/d for 3 weeks, vs doxycycline, 200 mg/d for 2 weeks, odds ratio, 1.28; 95% CI, 0.49-3.34). Treatment failures were rare at both 2 months (4%; 95% CI, 2%-5%) and 12 months (2%, 95% CI, 1%-3%) after treatment initiation. There were also no differences in the effect sizes among antibiotic agents and treatment modalities for treatment-related adverse outcomes, which were generally mild to moderate. Certainty of evidence was categorized as low and very low mostly because of imprecision, indirectness, and study limitations (high risk of bias) of the included studies.This NMA suggests that neither the antibiotic agent nor treatment modality contributed to comparative effectiveness or drug-related adverse outcomes. This finding is relevant for physicians treating patients with LB and for patient decision making." @default.
• W2894711779 created "2018-10-12" @default.
• W2894711779 creator A5010569274 @default.
• W2894711779 creator A5019261801 @default.
• W2894711779 creator A5024286601 @default.
• W2894711779 creator A5030850537 @default.
• W2894711779 creator A5035347495 @default.
• W2894711779 creator A5048775979 @default.
• W2894711779 creator A5049822409 @default.
• W2894711779 creator A5057755516 @default.
• W2894711779 creator A5064290666 @default.
• W2894711779 creator A5067399741 @default.
• W2894711779 date "2018-11-01" @default.
• W2894711779 modified "2023-10-10" @default.
• W2894711779 title "Efficacy and Safety of Antibiotic Therapy in Early Cutaneous Lyme Borreliosis" @default.
• W2894711779 cites W1000192467 @default.
• W2894711779 cites W1492852586 @default.
• W2894711779 cites W1495967812 @default.
• W2894711779 cites W1530837008 @default.
• W2894711779 cites W1560609550 @default.
• W2894711779 cites W1573723637 @default.
• W2894711779 cites W1604810570 @default.
• W2894711779 cites W1617328014 @default.
• W2894711779 cites W176162767 @default.
• W2894711779 cites W1837433396 @default.
• W2894711779 cites W1866000414 @default.
• W2894711779 cites W1903678843 @default.
• W2894711779 cites W1914817624 @default.
• W2894711779 cites W1947222380 @default.
• W2894711779 cites W1979924319 @default.
• W2894711779 cites W1980029675 @default.
• W2894711779 cites W1980261135 @default.
• W2894711779 cites W1984576495 @default.
• W2894711779 cites W1991356715 @default.
• W2894711779 cites W1993228662 @default.
• W2894711779 cites W2000339092 @default.
• W2894711779 cites W2007534126 @default.
• W2894711779 cites W2011276680 @default.
• W2894711779 cites W2018306931 @default.
• W2894711779 cites W2019012492 @default.
• W2894711779 cites W2032369525 @default.
• W2894711779 cites W2032719386 @default.
• W2894711779 cites W2057858700 @default.
• W2894711779 cites W2058469393 @default.
• W2894711779 cites W2074147400 @default.
• W2894711779 cites W2091177595 @default.
• W2894711779 cites W2091888019 @default.
• W2894711779 cites W2103961250 @default.
• W2894711779 cites W2109696289 @default.
• W2894711779 cites W2114127072 @default.
• W2894711779 cites W2120576551 @default.
• W2894711779 cites W2123475294 @default.
• W2894711779 cites W2132417459 @default.
• W2894711779 cites W2132546705 @default.
• W2894711779 cites W2133866452 @default.
• W2894711779 cites W2135400982 @default.
• W2894711779 cites W2135476530 @default.
• W2894711779 cites W2143865809 @default.
• W2894711779 cites W2146665904 @default.
• W2894711779 cites W2147700937 @default.
• W2894711779 cites W2155798268 @default.
• W2894711779 cites W2161612644 @default.
• W2894711779 cites W2172372618 @default.
• W2894711779 cites W2304410414 @default.
• W2894711779 cites W2324630307 @default.
• W2894711779 cites W2344599923 @default.
• W2894711779 cites W2346704363 @default.
• W2894711779 cites W2397704732 @default.
• W2894711779 cites W2411314626 @default.
• W2894711779 cites W2419545101 @default.
• W2894711779 cites W2527038934 @default.
• W2894711779 cites W2559748157 @default.
• W2894711779 cites W2594455611 @default.
• W2894711779 cites W2767579289 @default.
• W2894711779 cites W2786910707 @default.
• W2894711779 cites W2792647430 @default.
• W2894711779 cites W2897247590 @default.
• W2894711779 cites W2980754596 @default.
• W2894711779 cites W4210406669 @default.
• W2894711779 cites W4211094317 @default.
• W2894711779 cites W4231126867 @default.
• W2894711779 cites W4249999102 @default.
• W2894711779 cites W93740094 @default.
• W2894711779 doi "https://doi.org/10.1001/jamadermatol.2018.3186" @default.
• W2894711779 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6248135" @default.
• W2894711779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30285069" @default.
• W2894711779 hasPublicationYear "2018" @default.
• W2894711779 type Work @default.
• W2894711779 sameAs 2894711779 @default.
• W2894711779 citedByCount "29" @default.
• W2894711779 countsByYear W28947117792019 @default.
• W2894711779 countsByYear W28947117792020 @default.
• W2894711779 countsByYear W28947117792021 @default.
• W2894711779 countsByYear W28947117792022 @default.
• W2894711779 countsByYear W28947117792023 @default.
• W2894711779 crossrefType "journal-article" @default.
• W2894711779 hasAuthorship W2894711779A5010569274 @default.
• W2894711779 hasAuthorship W2894711779A5019261801 @default.

• next