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- W2894712468 abstract "Introduction: This study aims to examine the relevance of Red cell Distribution Width and other blood cell indices as a biomarker in differentiating between benign and malignant diseases of the gallbladder. Methods: Between January 2015 and April 2017, 135 subjects who fit the inclusion criteria were recruited. Baseline evaluations were carried out. Patients having benign gall stone disease underwent laparoscopic or open cholecystectomy. Operable cases of carcinoma were taken up for surgery. Resected specimen underwent histopathological analysis. Results: Of 135 subjects 48 had carcinoma Gallbladder and 87 had benign gallstone disease. In the benign group mean red cell distribution width was 15.3 ± 1.7% whereas in the carcinoma group was 16.4 ± 3.0% (p = 0.002). Sensitivity and specificity for a cut-off value of 16.05% was at 48% and 71% respectively. The mean Neutrophil Lymphocyte Ratio of patients of the benign group was 2.2 ± 0.9 versus carcinoma group was 3.8±2.9 (p < 0.001). The mean Platelet Lymphocyte Ratio of patients in benign group was 120.3 ± 56.3 versus 149.7 ± 95.8 in the carcinoma group (p = 0.002). The mean prognostic nutritional index of patients in the benign group was 53.6 ± 6.3 whereas in the carcinoma group was 47.8 ± 8.4 (p < 0.001). Conclusions: Red cell Distribution Width and other inflammatory markers like Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio have a role in predicting carcinoma Gall Bladder from benign disease in the preoperative period, which may help in the surgical management." @default.
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- W2894712468 date "2018-09-01" @default.
- W2894712468 modified "2023-09-27" @default.
- W2894712468 title "Role of red cell distribution width and other blood cell indices in differentiating between benign and malignant diseases of gallbladder" @default.
- W2894712468 doi "https://doi.org/10.1016/j.hpb.2018.06.1413" @default.
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