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- W2894722159 abstract "Mammalian gametes and embryos are particularly vulnerable to oxidative stress-induced damage, which is mainly caused by reactive oxygen species (ROS) originating from normal metabolism and/or the external environment. Several researchers have implicated the role of oxidative stress in the activation of apoptosis, causing peroxidative damage to sperms/oocytes and inducing embryo fragmentation, arrest, or demise. Melatonin is a tryptophan derivative that is known for its powerful free radical-scavenging activity and broad-spectrum antioxidant property. Numerous studies have shown that melatonin and its metabolic derivatives can sequentially detoxify ROS in an antioxidant cascade, and modulate various antioxidant enzymes via its receptors to prevent radical-mediated damage. The identification of melatonin receptors in cumulus/granulosa cells, oocytes, and epididymal tissues implies that melatonin has protective actions on gametes and embryos. Enriching the semen extender or culture medium with melatonin significantly benefits sperm characteristics, improves oocyte maturation potential and quality, and enhances the developmental competence of preimplantation embryos. Certainly, further comparative studies are needed to show the unique antioxidant role and the advantage of melatonin in this field. This review summarizes the harmful effects of ROS and the beneficial role of melatonin against oxidative damage of gametes and embryos." @default.
- W2894722159 created "2018-10-12" @default.
- W2894722159 creator A5028035166 @default.
- W2894722159 creator A5037913379 @default.
- W2894722159 creator A5050163710 @default.
- W2894722159 creator A5052761486 @default.
- W2894722159 creator A5064657543 @default.
- W2894722159 date "2018-10-01" @default.
- W2894722159 modified "2023-09-25" @default.
- W2894722159 title "Beneficial role of melatonin in protecting mammalian gametes and embryos from oxidative damage" @default.
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