FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894727175> ?p ?o ?g. }

• W2894727175 endingPage "375" @default.
• W2894727175 startingPage "359" @default.
• W2894727175 abstract "The formation of amyloid-β (Aβ) peptides is causally involved in the development of Alzheimer's disease (AD). A significant proportion of deposited Aβ is N-terminally truncated and modified at the N-terminus by a pGlu-residue (pGlu-Aβ). These forms show enhanced neurotoxicity compared to full-length Aβ. Although the truncation may occur by aminopeptidases after formation of Aβ, recently discovered processing pathways of amyloid-β protein precursor (AβPP) by proteases such as meprin β may also be involved. Here, we assessed a role of meprin β in forming Aβ3-40/42, which is the precursor of pGlu-Aβ3-40/42 generated by glutaminyl cyclase (QC). Similar to QC, meprin β mRNA is significantly upregulated in postmortem brain from AD patients. A histochemical analysis supports the presence of meprin β in neurons and astrocytes in the vicinity of pGlu-Aβ containing deposits. Cleavage of AβPP-derived peptides by meprin β in vitro results in peptides Aβ1-x, Aβ2-x, and Aβ3-x. The formation of N-truncated Aβ by meprin β was also corroborated in cell culture. A subset of the generated peptides was converted into pGlu-Aβ3-40 by an addition of glutaminyl cyclase, supporting the preceding formation of Aβ3-40. Further analysis of the meprin β cleavage revealed a yet unknown dipeptidyl-peptidase-like activity specific for the N-terminus of Aβ1-x. Thus, our data suggest that meprin β contributes to the formation of N-truncated Aβ by endopeptidase and exopeptidase activity to generate the substrate for QC-catalyzed pGlu-Aβ formation." @default.
• W2894727175 created "2018-10-12" @default.
• W2894727175 creator A5000568327 @default.
• W2894727175 creator A5001127178 @default.
• W2894727175 creator A5005145881 @default.
• W2894727175 creator A5012403453 @default.
• W2894727175 creator A5014415849 @default.
• W2894727175 creator A5040572132 @default.
• W2894727175 creator A5048371545 @default.
• W2894727175 creator A5050561092 @default.
• W2894727175 creator A5053141270 @default.
• W2894727175 creator A5053310941 @default.
• W2894727175 creator A5064065407 @default.
• W2894727175 creator A5086688856 @default.
• W2894727175 creator A5091116058 @default.
• W2894727175 date "2018-10-16" @default.
• W2894727175 modified "2023-09-25" @default.
• W2894727175 title "Dipeptidyl-Peptidase Activity of Meprin β Links N-truncation of Aβ with Glutaminyl Cyclase-Catalyzed pGlu-Aβ Formation" @default.
• W2894727175 cites W1250804522 @default.
• W2894727175 cites W1500808124 @default.
• W2894727175 cites W1514539285 @default.
• W2894727175 cites W1552912270 @default.
• W2894727175 cites W1587774683 @default.
• W2894727175 cites W166433058 @default.
• W2894727175 cites W1974145718 @default.
• W2894727175 cites W1990632702 @default.
• W2894727175 cites W2007389732 @default.
• W2894727175 cites W2012288880 @default.
• W2894727175 cites W2016920663 @default.
• W2894727175 cites W2024656644 @default.
• W2894727175 cites W2024866120 @default.
• W2894727175 cites W2026326610 @default.
• W2894727175 cites W2028578297 @default.
• W2894727175 cites W2028938218 @default.
• W2894727175 cites W2032958786 @default.
• W2894727175 cites W2035553534 @default.
• W2894727175 cites W2039239447 @default.
• W2894727175 cites W2052742260 @default.
• W2894727175 cites W2062100528 @default.
• W2894727175 cites W2064566310 @default.
• W2894727175 cites W2071310220 @default.
• W2894727175 cites W2075967168 @default.
• W2894727175 cites W2076215391 @default.
• W2894727175 cites W2080592458 @default.
• W2894727175 cites W2082452187 @default.
• W2894727175 cites W2085211004 @default.
• W2894727175 cites W2087697089 @default.
• W2894727175 cites W2091959459 @default.
• W2894727175 cites W2095253097 @default.
• W2894727175 cites W2097812689 @default.
• W2894727175 cites W2130270031 @default.
• W2894727175 cites W2139703570 @default.
• W2894727175 cites W2142509486 @default.
• W2894727175 cites W2149677668 @default.
• W2894727175 cites W2154735761 @default.
• W2894727175 cites W2204663410 @default.
• W2894727175 cites W2275405720 @default.
• W2894727175 cites W2465745215 @default.
• W2894727175 cites W2511205725 @default.
• W2894727175 cites W2568990702 @default.
• W2894727175 doi "https://doi.org/10.3233/jad-171183" @default.
• W2894727175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30320570" @default.
• W2894727175 hasPublicationYear "2018" @default.
• W2894727175 type Work @default.
• W2894727175 sameAs 2894727175 @default.
• W2894727175 citedByCount "19" @default.
• W2894727175 countsByYear W28947271752019 @default.
• W2894727175 countsByYear W28947271752020 @default.
• W2894727175 countsByYear W28947271752021 @default.
• W2894727175 countsByYear W28947271752022 @default.
• W2894727175 countsByYear W28947271752023 @default.
• W2894727175 crossrefType "journal-article" @default.
• W2894727175 hasAuthorship W2894727175A5000568327 @default.
• W2894727175 hasAuthorship W2894727175A5001127178 @default.
• W2894727175 hasAuthorship W2894727175A5005145881 @default.
• W2894727175 hasAuthorship W2894727175A5012403453 @default.
• W2894727175 hasAuthorship W2894727175A5014415849 @default.
• W2894727175 hasAuthorship W2894727175A5040572132 @default.
• W2894727175 hasAuthorship W2894727175A5048371545 @default.
• W2894727175 hasAuthorship W2894727175A5050561092 @default.
• W2894727175 hasAuthorship W2894727175A5053141270 @default.
• W2894727175 hasAuthorship W2894727175A5053310941 @default.
• W2894727175 hasAuthorship W2894727175A5064065407 @default.
• W2894727175 hasAuthorship W2894727175A5086688856 @default.
• W2894727175 hasAuthorship W2894727175A5091116058 @default.
• W2894727175 hasConcept C104317684 @default.
• W2894727175 hasConcept C127561419 @default.
• W2894727175 hasConcept C151730666 @default.
• W2894727175 hasConcept C153911025 @default.
• W2894727175 hasConcept C175156509 @default.
• W2894727175 hasConcept C181199279 @default.
• W2894727175 hasConcept C182220744 @default.
• W2894727175 hasConcept C185592680 @default.
• W2894727175 hasConcept C2777774944 @default.
• W2894727175 hasConcept C2781469919 @default.
• W2894727175 hasConcept C43369102 @default.
• W2894727175 hasConcept C55493867 @default.
• W2894727175 hasConcept C55728118 @default.

• next