FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894727276> ?p ?o ?g. }

• W2894727276 endingPage "7042" @default.
• W2894727276 startingPage "7033" @default.
• W2894727276 abstract "There is a considerable global burden of invasive group B streptococcal (GBS) disease. Vaccines are being developed for use in pregnant women to offer protection to neonates. To estimate the potential impact and cost-effectiveness of maternal immunisation against neonatal and maternal invasive GBS disease in the UK. We developed a decision-tree model encompassing GBS-related events in infants and mothers, following a birth cohort with a time horizon equivalent to average life expectancy (81 years). We parameterised the model using contemporary data from disease surveillance and outcomes in GBS survivors. Costs were taken from NHS sources and research studies. Maternal immunisation in combination with risk-based intrapartum antibiotic prophylaxis (IAP) was compared to the current standard practice of risk-based IAP alone from an NHS and Personal Social Services (health-provider) perspective. We estimated the cases averted and cost per QALY gained through vaccination. One-way sensitivity analysis, scenario analysis and probabilistic sensitivity analysis were performed. An effective maternal immunisation programme could substantially reduce the burden of GBS disease. The deterministic analysis estimated the threshold cost-effective price for a GBS vaccine to be £54 per dose at £20,000/QALY (£71 per dose at £30,000/QALY). Results were most sensitive to assumptions on disease incidence, sequelae rate and vaccine efficacy. Probabilistic analysis showed 90.66% of iterations fell under the £30,000 threshold at a vaccine price of £55. Inclusion of modest prevention of stillbirths and/or, preterm births, carer health impacts, maternal GBS deaths and 1.5% discounting improved cost-effectiveness compared to the base case. Lowering vaccine strain coverage made the vaccine less cost-effective. A key limitation is that the properties of the final GBS vaccine are unknown. Maternal GBS immunisation is expected to be cost-effective, even at a relatively high vaccine price." @default.
• W2894727276 created "2018-10-12" @default.
• W2894727276 creator A5014571718 @default.
• W2894727276 creator A5016489221 @default.
• W2894727276 creator A5026204216 @default.
• W2894727276 creator A5046888535 @default.
• W2894727276 creator A5065434292 @default.
• W2894727276 creator A5080468598 @default.
• W2894727276 creator A5080976462 @default.
• W2894727276 creator A5082401018 @default.
• W2894727276 date "2018-11-01" @default.
• W2894727276 modified "2023-10-16" @default.
• W2894727276 title "Cost-effectiveness analysis of maternal immunisation against group B Streptococcus (GBS) disease: A modelling study" @default.
• W2894727276 cites W1563898043 @default.
• W2894727276 cites W166560170 @default.
• W2894727276 cites W1909562790 @default.
• W2894727276 cites W1967954801 @default.
• W2894727276 cites W1975298598 @default.
• W2894727276 cites W1986625368 @default.
• W2894727276 cites W1998717627 @default.
• W2894727276 cites W2001575002 @default.
• W2894727276 cites W2044736986 @default.
• W2894727276 cites W2048582865 @default.
• W2894727276 cites W2053413774 @default.
• W2894727276 cites W2055951153 @default.
• W2894727276 cites W2070396469 @default.
• W2894727276 cites W2121403515 @default.
• W2894727276 cites W2131971532 @default.
• W2894727276 cites W2138218123 @default.
• W2894727276 cites W2138377906 @default.
• W2894727276 cites W2140132212 @default.
• W2894727276 cites W2147853208 @default.
• W2894727276 cites W2173363634 @default.
• W2894727276 cites W2216185775 @default.
• W2894727276 cites W2340167029 @default.
• W2894727276 cites W2342773131 @default.
• W2894727276 cites W2400945511 @default.
• W2894727276 cites W2508918484 @default.
• W2894727276 cites W25177459 @default.
• W2894727276 cites W2561215256 @default.
• W2894727276 cites W2758000496 @default.
• W2894727276 cites W2767490364 @default.
• W2894727276 cites W2767873520 @default.
• W2894727276 cites W4210669635 @default.
• W2894727276 cites W4324263116 @default.
• W2894727276 doi "https://doi.org/10.1016/j.vaccine.2018.09.058" @default.
• W2894727276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30293765" @default.
• W2894727276 hasPublicationYear "2018" @default.
• W2894727276 type Work @default.
• W2894727276 sameAs 2894727276 @default.
• W2894727276 citedByCount "19" @default.
• W2894727276 countsByYear W28947272762018 @default.
• W2894727276 countsByYear W28947272762019 @default.
• W2894727276 countsByYear W28947272762020 @default.
• W2894727276 countsByYear W28947272762021 @default.
• W2894727276 countsByYear W28947272762022 @default.
• W2894727276 countsByYear W28947272762023 @default.
• W2894727276 crossrefType "journal-article" @default.
• W2894727276 hasAuthorship W2894727276A5014571718 @default.
• W2894727276 hasAuthorship W2894727276A5016489221 @default.
• W2894727276 hasAuthorship W2894727276A5026204216 @default.
• W2894727276 hasAuthorship W2894727276A5046888535 @default.
• W2894727276 hasAuthorship W2894727276A5065434292 @default.
• W2894727276 hasAuthorship W2894727276A5080468598 @default.
• W2894727276 hasAuthorship W2894727276A5080976462 @default.
• W2894727276 hasAuthorship W2894727276A5082401018 @default.
• W2894727276 hasBestOaLocation W28947272762 @default.
• W2894727276 hasConcept C112930515 @default.
• W2894727276 hasConcept C120665830 @default.
• W2894727276 hasConcept C121332964 @default.
• W2894727276 hasConcept C126322002 @default.
• W2894727276 hasConcept C187212893 @default.
• W2894727276 hasConcept C203014093 @default.
• W2894727276 hasConcept C22070199 @default.
• W2894727276 hasConcept C2777785397 @default.
• W2894727276 hasConcept C2779134260 @default.
• W2894727276 hasConcept C2779234561 @default.
• W2894727276 hasConcept C2780664029 @default.
• W2894727276 hasConcept C3019080777 @default.
• W2894727276 hasConcept C515549039 @default.
• W2894727276 hasConcept C54355233 @default.
• W2894727276 hasConcept C61511704 @default.
• W2894727276 hasConcept C71924100 @default.
• W2894727276 hasConcept C86803240 @default.
• W2894727276 hasConceptScore W2894727276C112930515 @default.
• W2894727276 hasConceptScore W2894727276C120665830 @default.
• W2894727276 hasConceptScore W2894727276C121332964 @default.
• W2894727276 hasConceptScore W2894727276C126322002 @default.
• W2894727276 hasConceptScore W2894727276C187212893 @default.
• W2894727276 hasConceptScore W2894727276C203014093 @default.
• W2894727276 hasConceptScore W2894727276C22070199 @default.
• W2894727276 hasConceptScore W2894727276C2777785397 @default.
• W2894727276 hasConceptScore W2894727276C2779134260 @default.
• W2894727276 hasConceptScore W2894727276C2779234561 @default.
• W2894727276 hasConceptScore W2894727276C2780664029 @default.
• W2894727276 hasConceptScore W2894727276C3019080777 @default.
• W2894727276 hasConceptScore W2894727276C515549039 @default.
• W2894727276 hasConceptScore W2894727276C54355233 @default.

• next