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- W2894729867 abstract "Abstract Meiotic recombination has strong, but poorly understood, effects on short tandem repeat (STR) instability. Here, we screened thousands of single recombinant products to characterize the transmission and evolution of polymorphic poly-A repeats at a human recombination hotspot. We show that length asymmetry between heterozygous poly-As plays a key role in the recombination outcome and their transmission. A difference of 10 As (9A/19A) elevates the frequency of non-crossovers, complex recombination products, and long conversion tracts. Moreover, asymmetry also influences STR transmission: the shorter allele is transmitted more frequently (deletion bias) at the asymmetric STR (9A/19A), while the longer allele is favored (insertion bias) at the site with a small STR length difference (6A/7A). Finally, potentially due to this opposing insertion/deletion driven evolution, we find that poly-As are enriched at human recombination hotspots predominantly with short poly-As, possibly influencing open chromatin regions that in turn can activate hotspots." @default.
- W2894729867 created "2018-10-12" @default.
- W2894729867 creator A5011496906 @default.
- W2894729867 creator A5034649119 @default.
- W2894729867 creator A5045799799 @default.
- W2894729867 creator A5062495434 @default.
- W2894729867 creator A5081160694 @default.
- W2894729867 creator A5082929641 @default.
- W2894729867 creator A5088088821 @default.
- W2894729867 creator A5089887135 @default.
- W2894729867 date "2018-10-03" @default.
- W2894729867 modified "2023-09-27" @default.
- W2894729867 title "Length asymmetry and heterozygosity strongly influences the evolution of poly-A microsatellites at meiotic recombination hotspots" @default.
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