Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894739441> ?p ?o ?g. }
- W2894739441 abstract "Abstract Multiple Sclerosis (MS) is characterized by focal CNS inflammation leading to the death of oligodendrocytes (OLs) with subsequent demyelination, neuronal degeneration, and severe functional deficits. Inhibitory chondroitin sulfate proteoglycans (CSPGs) are increased in the extracellular matrix in the vicinity of MS lesions and are thought to play a critical role in myelin regeneration failure. We here show that CSPGs curtail remyelination through binding with their cognate receptor, protein tyrosine phosphatase σ (PTPσ) on oligodendrocyte progenitor cells (OPCs). We report that inhibition of CSPG/PTPσ signaling by systemically deliverable Intracellular Sigma Peptide (ISP), promotes OPC migration, maturation, remyelination, and functional recovery in animal models of MS. Furthermore, we report a downstream molecular target of PTPσ modulation in OPCs involving upregulation of the protease MMP-2 that allows OPCs to enzymatically digest their way through CSPGs. In total, we demonstrate a critical role of PTPσ/CSPG interactions in OPC remyelination in MS." @default.
- W2894739441 created "2018-10-12" @default.
- W2894739441 creator A5001997941 @default.
- W2894739441 creator A5009011088 @default.
- W2894739441 creator A5019400191 @default.
- W2894739441 creator A5029930363 @default.
- W2894739441 creator A5043396522 @default.
- W2894739441 creator A5049160126 @default.
- W2894739441 creator A5061088955 @default.
- W2894739441 date "2018-10-08" @default.
- W2894739441 modified "2023-10-16" @default.
- W2894739441 title "Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis" @default.
- W2894739441 cites W1483922385 @default.
- W2894739441 cites W1526747027 @default.
- W2894739441 cites W1689660630 @default.
- W2894739441 cites W1822650859 @default.
- W2894739441 cites W1824808675 @default.
- W2894739441 cites W1846608835 @default.
- W2894739441 cites W1967109943 @default.
- W2894739441 cites W1979104943 @default.
- W2894739441 cites W1981734899 @default.
- W2894739441 cites W1982439010 @default.
- W2894739441 cites W1997912239 @default.
- W2894739441 cites W2011353038 @default.
- W2894739441 cites W2013997823 @default.
- W2894739441 cites W2017847893 @default.
- W2894739441 cites W2029976952 @default.
- W2894739441 cites W2041302528 @default.
- W2894739441 cites W2043930451 @default.
- W2894739441 cites W2048082433 @default.
- W2894739441 cites W2054275187 @default.
- W2894739441 cites W2054633821 @default.
- W2894739441 cites W2061522969 @default.
- W2894739441 cites W2064423627 @default.
- W2894739441 cites W2071919985 @default.
- W2894739441 cites W2075266360 @default.
- W2894739441 cites W2085444662 @default.
- W2894739441 cites W2086013406 @default.
- W2894739441 cites W2086085796 @default.
- W2894739441 cites W2086408483 @default.
- W2894739441 cites W2097530133 @default.
- W2894739441 cites W2108438047 @default.
- W2894739441 cites W2114319271 @default.
- W2894739441 cites W2116447863 @default.
- W2894739441 cites W2125272974 @default.
- W2894739441 cites W2135479557 @default.
- W2894739441 cites W2142437726 @default.
- W2894739441 cites W2148353419 @default.
- W2894739441 cites W2157780675 @default.
- W2894739441 cites W2161456562 @default.
- W2894739441 cites W2164956116 @default.
- W2894739441 cites W2165521823 @default.
- W2894739441 cites W2167995816 @default.
- W2894739441 cites W2294640652 @default.
- W2894739441 cites W2344942352 @default.
- W2894739441 cites W2416766237 @default.
- W2894739441 cites W2613217394 @default.
- W2894739441 cites W2617378566 @default.
- W2894739441 cites W2751174227 @default.
- W2894739441 cites W2794351872 @default.
- W2894739441 cites W2803963145 @default.
- W2894739441 cites W2804151471 @default.
- W2894739441 cites W61719800 @default.
- W2894739441 doi "https://doi.org/10.1038/s41467-018-06505-6" @default.
- W2894739441 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6175851" @default.
- W2894739441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30297691" @default.
- W2894739441 hasPublicationYear "2018" @default.
- W2894739441 type Work @default.
- W2894739441 sameAs 2894739441 @default.
- W2894739441 citedByCount "46" @default.
- W2894739441 countsByYear W28947394412019 @default.
- W2894739441 countsByYear W28947394412020 @default.
- W2894739441 countsByYear W28947394412021 @default.
- W2894739441 countsByYear W28947394412022 @default.
- W2894739441 countsByYear W28947394412023 @default.
- W2894739441 crossrefType "journal-article" @default.
- W2894739441 hasAuthorship W2894739441A5001997941 @default.
- W2894739441 hasAuthorship W2894739441A5009011088 @default.
- W2894739441 hasAuthorship W2894739441A5019400191 @default.
- W2894739441 hasAuthorship W2894739441A5029930363 @default.
- W2894739441 hasAuthorship W2894739441A5043396522 @default.
- W2894739441 hasAuthorship W2894739441A5049160126 @default.
- W2894739441 hasAuthorship W2894739441A5061088955 @default.
- W2894739441 hasBestOaLocation W28947394411 @default.
- W2894739441 hasConcept C104317684 @default.
- W2894739441 hasConcept C109523444 @default.
- W2894739441 hasConcept C127561419 @default.
- W2894739441 hasConcept C129987498 @default.
- W2894739441 hasConcept C169760540 @default.
- W2894739441 hasConcept C170493617 @default.
- W2894739441 hasConcept C185592680 @default.
- W2894739441 hasConcept C189165786 @default.
- W2894739441 hasConcept C203014093 @default.
- W2894739441 hasConcept C2775895372 @default.
- W2894739441 hasConcept C2776985911 @default.
- W2894739441 hasConcept C2777619251 @default.
- W2894739441 hasConcept C2778609137 @default.
- W2894739441 hasConcept C2779335624 @default.
- W2894739441 hasConcept C2780640218 @default.
- W2894739441 hasConcept C529278444 @default.