FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894740531> ?p ?o ?g. }

• W2894740531 abstract "An effective treatment for non-alcoholic fatty liver disease (NAFLD) is urgently needed. In the present study, we investigated whether the Chinese medicine Chai Hu Li Zhong Tang (CHLZT) could protect against the development of NAFLD. Rats in an animal model of NAFLD were treated with CHLZT, and their serum levels of cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were detected with an automatic biochemical analyzer. A cellular model of NAFLD was also established by culturing HepG2 cells in a medium that contained a long chain fat emulsion. Those cells were treated with CHLZT that contained serum from rats. After treatment, the levels of adenylate-activated protein kinase (AMPK) α (AMPKα), p-AMPKα, acetyl coenzyme A carboxylase (ACC) α (ACCα), pACCα, PPARγ, and SREBP-2 were detected. The AMPK agonist, acadesine (AICAR), was used as a positive control compound. Our results showed that CHLZT or AICAR significantly decreased the serum levels of TG, TC, LDL-C, AST, ALT, and insulin in NAFLD rats, and significantly increased their serum HDL-C levels. Treatments with CHLZT or AICAR significantly decreased the numbers of lipid droplets in NAFLD liver tissues and HepG2 cells. CHLZT and AICAR increased the levels of p-AMPKα and PPARγ in the NAFLD liver tissues and HepG2 cells, but decreased the levels of ACC-α, p-ACC-α, SREBP-2, and 3-hydroxyl-3-methylglutaryl-coenzyme A reductase (HMGR). CHLZT protects against NAFLD by activating AMPKα, and also by inhibiting ACC activity, down-regulating SREBP2 and HMGR, and up-regulating PPAR-γ. Our results suggest that CHLZT might be useful for treating NAFLD in the clinic." @default.
• W2894740531 created "2018-10-12" @default.
• W2894740531 creator A5000645986 @default.
• W2894740531 creator A5011540763 @default.
• W2894740531 creator A5058816588 @default.
• W2894740531 creator A5072315367 @default.
• W2894740531 creator A5074140059 @default.
• W2894740531 creator A5087818896 @default.
• W2894740531 date "2018-11-07" @default.
• W2894740531 modified "2023-10-12" @default.
• W2894740531 title "The Chinese medicine Chai Hu Li Zhong Tang protects against non-alcoholic fatty liver disease by activating AMPKα" @default.
• W2894740531 cites W1585700338 @default.
• W2894740531 cites W1702423934 @default.
• W2894740531 cites W1847769555 @default.
• W2894740531 cites W1921317788 @default.
• W2894740531 cites W1968333067 @default.
• W2894740531 cites W1977194186 @default.
• W2894740531 cites W1978723895 @default.
• W2894740531 cites W1998143374 @default.
• W2894740531 cites W2015315045 @default.
• W2894740531 cites W2021710604 @default.
• W2894740531 cites W2045399735 @default.
• W2894740531 cites W2059103037 @default.
• W2894740531 cites W2064445967 @default.
• W2894740531 cites W2065895918 @default.
• W2894740531 cites W2066092624 @default.
• W2894740531 cites W2079120799 @default.
• W2894740531 cites W2080348345 @default.
• W2894740531 cites W2085298586 @default.
• W2894740531 cites W2091760532 @default.
• W2894740531 cites W2104224695 @default.
• W2894740531 cites W2137642531 @default.
• W2894740531 cites W2148717732 @default.
• W2894740531 cites W2336496894 @default.
• W2894740531 cites W2513762532 @default.
• W2894740531 cites W2524556587 @default.
• W2894740531 cites W2547304276 @default.
• W2894740531 cites W2556419785 @default.
• W2894740531 cites W2564229594 @default.
• W2894740531 cites W2735859713 @default.
• W2894740531 cites W2736924678 @default.
• W2894740531 cites W2738689405 @default.
• W2894740531 cites W2744297809 @default.
• W2894740531 cites W2760304035 @default.
• W2894740531 cites W2766031756 @default.
• W2894740531 cites W2772313308 @default.
• W2894740531 cites W2773466959 @default.
• W2894740531 cites W2774672890 @default.
• W2894740531 cites W2777492628 @default.
• W2894740531 cites W2778273119 @default.
• W2894740531 cites W2781156503 @default.
• W2894740531 cites W2782740634 @default.
• W2894740531 cites W2791300176 @default.
• W2894740531 cites W2791320197 @default.
• W2894740531 doi "https://doi.org/10.1042/bsr20180644" @default.
• W2894740531 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6239269" @default.
• W2894740531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30291215" @default.
• W2894740531 hasPublicationYear "2018" @default.
• W2894740531 type Work @default.
• W2894740531 sameAs 2894740531 @default.
• W2894740531 citedByCount "12" @default.
• W2894740531 countsByYear W28947405312019 @default.
• W2894740531 countsByYear W28947405312020 @default.
• W2894740531 countsByYear W28947405312021 @default.
• W2894740531 countsByYear W28947405312022 @default.
• W2894740531 countsByYear W28947405312023 @default.
• W2894740531 crossrefType "journal-article" @default.
• W2894740531 hasAuthorship W2894740531A5000645986 @default.
• W2894740531 hasAuthorship W2894740531A5011540763 @default.
• W2894740531 hasAuthorship W2894740531A5058816588 @default.
• W2894740531 hasAuthorship W2894740531A5072315367 @default.
• W2894740531 hasAuthorship W2894740531A5074140059 @default.
• W2894740531 hasAuthorship W2894740531A5087818896 @default.
• W2894740531 hasBestOaLocation W28947405311 @default.
• W2894740531 hasConcept C126322002 @default.
• W2894740531 hasConcept C134018914 @default.
• W2894740531 hasConcept C184235292 @default.
• W2894740531 hasConcept C185592680 @default.
• W2894740531 hasConcept C2776954865 @default.
• W2894740531 hasConcept C2778163477 @default.
• W2894740531 hasConcept C2778772119 @default.
• W2894740531 hasConcept C2778913445 @default.
• W2894740531 hasConcept C2779134260 @default.
• W2894740531 hasConcept C2780124434 @default.
• W2894740531 hasConcept C55493867 @default.
• W2894740531 hasConcept C71924100 @default.
• W2894740531 hasConcept C97029542 @default.
• W2894740531 hasConceptScore W2894740531C126322002 @default.
• W2894740531 hasConceptScore W2894740531C134018914 @default.
• W2894740531 hasConceptScore W2894740531C184235292 @default.
• W2894740531 hasConceptScore W2894740531C185592680 @default.
• W2894740531 hasConceptScore W2894740531C2776954865 @default.
• W2894740531 hasConceptScore W2894740531C2778163477 @default.
• W2894740531 hasConceptScore W2894740531C2778772119 @default.
• W2894740531 hasConceptScore W2894740531C2778913445 @default.
• W2894740531 hasConceptScore W2894740531C2779134260 @default.
• W2894740531 hasConceptScore W2894740531C2780124434 @default.
• W2894740531 hasConceptScore W2894740531C55493867 @default.
• W2894740531 hasConceptScore W2894740531C71924100 @default.
• W2894740531 hasConceptScore W2894740531C97029542 @default.

• next