FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894742196> ?p ?o ?g. }

• W2894742196 endingPage "61" @default.
• W2894742196 startingPage "61" @default.
• W2894742196 abstract "Duchenne muscular dystrophy (DMD) is a musculoskeletal disorder that causes severe morbidity and reduced lifespan. Individuals with DMD have an X-linked mutation that impairs their ability to produce functional dystrophin protein in muscle. No cure exists for this disease and the few therapies that are available do not dramatically delay disease progression. Thus, there is a need to better understand the mechanisms underlying DMD which may ultimately lead to improved treatment options. The muscular dystrophy (MDX) mouse model is frequently used to explore DMD disease traits. Though some studies of metabolism in dystrophic mice exist, few have characterized metabolic profiles of supporting cells in the diseased environment. Using nontargeted metabolomics we characterized metabolic alterations in muscle satellite cells (SCs) and serum of MDX mice. Additionally, live-cell imaging revealed MDX-derived adipose progenitor cell (APC) defects. Finally, metabolomic studies revealed a striking elevation of acylcarnitines in MDX APCs, which we show can inhibit APC proliferation. Together, these studies highlight widespread metabolic alterations in multiple progenitor cell types and serum from MDX mice and implicate dystrophy-associated metabolite imbalances in APCs as a potential contributor to adipose tissue disequilibrium in DMD." @default.
• W2894742196 created "2018-10-12" @default.
• W2894742196 creator A5026162365 @default.
• W2894742196 creator A5032456136 @default.
• W2894742196 creator A5091745569 @default.
• W2894742196 date "2018-10-03" @default.
• W2894742196 modified "2023-10-09" @default.
• W2894742196 title "Metabolomic Analyses Reveal Extensive Progenitor Cell Deficiencies in a Mouse Model of Duchenne Muscular Dystrophy" @default.
• W2894742196 cites W1104877127 @default.
• W2894742196 cites W139026977 @default.
• W2894742196 cites W1964393311 @default.
• W2894742196 cites W1965468419 @default.
• W2894742196 cites W1969645113 @default.
• W2894742196 cites W1971672202 @default.
• W2894742196 cites W1974256573 @default.
• W2894742196 cites W1974333026 @default.
• W2894742196 cites W1976327004 @default.
• W2894742196 cites W1987980762 @default.
• W2894742196 cites W1993771690 @default.
• W2894742196 cites W2019160367 @default.
• W2894742196 cites W2019563312 @default.
• W2894742196 cites W2022570317 @default.
• W2894742196 cites W2050860068 @default.
• W2894742196 cites W2064612269 @default.
• W2894742196 cites W2066180106 @default.
• W2894742196 cites W2066280893 @default.
• W2894742196 cites W2070936696 @default.
• W2894742196 cites W2073381691 @default.
• W2894742196 cites W2083537465 @default.
• W2894742196 cites W2089095793 @default.
• W2894742196 cites W2092990269 @default.
• W2894742196 cites W2097136884 @default.
• W2894742196 cites W2105427226 @default.
• W2894742196 cites W2112136564 @default.
• W2894742196 cites W2113580841 @default.
• W2894742196 cites W2114003006 @default.
• W2894742196 cites W2137714739 @default.
• W2894742196 cites W2154318907 @default.
• W2894742196 cites W2157104859 @default.
• W2894742196 cites W2159671087 @default.
• W2894742196 cites W2169365167 @default.
• W2894742196 cites W2194012442 @default.
• W2894742196 cites W2277846589 @default.
• W2894742196 cites W2337696333 @default.
• W2894742196 cites W2346705222 @default.
• W2894742196 cites W2419387337 @default.
• W2894742196 cites W2463932592 @default.
• W2894742196 cites W2570756670 @default.
• W2894742196 cites W2739978142 @default.
• W2894742196 cites W2752202814 @default.
• W2894742196 cites W2789677066 @default.
• W2894742196 cites W2793317983 @default.
• W2894742196 cites W2800569219 @default.
• W2894742196 cites W2809518685 @default.
• W2894742196 doi "https://doi.org/10.3390/metabo8040061" @default.
• W2894742196 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6315702" @default.
• W2894742196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30282911" @default.
• W2894742196 hasPublicationYear "2018" @default.
• W2894742196 type Work @default.
• W2894742196 sameAs 2894742196 @default.
• W2894742196 citedByCount "17" @default.
• W2894742196 countsByYear W28947421962019 @default.
• W2894742196 countsByYear W28947421962020 @default.
• W2894742196 countsByYear W28947421962021 @default.
• W2894742196 countsByYear W28947421962022 @default.
• W2894742196 countsByYear W28947421962023 @default.
• W2894742196 crossrefType "journal-article" @default.
• W2894742196 hasAuthorship W2894742196A5026162365 @default.
• W2894742196 hasAuthorship W2894742196A5032456136 @default.
• W2894742196 hasAuthorship W2894742196A5091745569 @default.
• W2894742196 hasBestOaLocation W28947421961 @default.
• W2894742196 hasConcept C126322002 @default.
• W2894742196 hasConcept C134018914 @default.
• W2894742196 hasConcept C171089720 @default.
• W2894742196 hasConcept C201750760 @default.
• W2894742196 hasConcept C21565614 @default.
• W2894742196 hasConcept C2778750056 @default.
• W2894742196 hasConcept C2778943923 @default.
• W2894742196 hasConcept C2779030066 @default.
• W2894742196 hasConcept C2780394045 @default.
• W2894742196 hasConcept C28328180 @default.
• W2894742196 hasConcept C60644358 @default.
• W2894742196 hasConcept C71924100 @default.
• W2894742196 hasConcept C86803240 @default.
• W2894742196 hasConcept C95444343 @default.
• W2894742196 hasConceptScore W2894742196C126322002 @default.
• W2894742196 hasConceptScore W2894742196C134018914 @default.
• W2894742196 hasConceptScore W2894742196C171089720 @default.
• W2894742196 hasConceptScore W2894742196C201750760 @default.
• W2894742196 hasConceptScore W2894742196C21565614 @default.
• W2894742196 hasConceptScore W2894742196C2778750056 @default.
• W2894742196 hasConceptScore W2894742196C2778943923 @default.
• W2894742196 hasConceptScore W2894742196C2779030066 @default.
• W2894742196 hasConceptScore W2894742196C2780394045 @default.
• W2894742196 hasConceptScore W2894742196C28328180 @default.
• W2894742196 hasConceptScore W2894742196C60644358 @default.
• W2894742196 hasConceptScore W2894742196C71924100 @default.
• W2894742196 hasConceptScore W2894742196C86803240 @default.

• next