Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894747471> ?p ?o ?g. }
- W2894747471 endingPage "381" @default.
- W2894747471 startingPage "368" @default.
- W2894747471 abstract "Pancreatic cancer is a challenging disease with a high mortality rate. While the importance of crosstalk between cancer and immune cells has been well documented, the understanding of this complex molecular network is incomplete. Thus, identification of the secreted proteins contributing to the immunosuppressive microenvironment in pancreatic cancer is crucial for effective diagnosis and/or therapy. We utilized a public microarray dataset (GSE16515) from the Gene Expression Omnibus database to identify genes for secreted proteins in pancreatic cancer. RT–PCR and ELISA of the pancreatic cancer cell lines validated the cellular origin of the selected genes. For functional assay of the selected proteins, we utilized human-monocyte-derived dendritic cells (DCs). From the list of the secreted proteins, trefoil factor 2 (TFF2) was further examined as a potential chemokine/cytokine. While TFF2 did not significantly affect the phenotypic maturation and the allostimulatory capacity of DCs, TFF2 preferentially attracted immature (but not mature) DCs and inhibited their endocytic activity. Our data suggest that TFF2 from pancreatic cancer cells may attract immature DCs and affect the initial stage of DC maturation, thereby contributing to the induction of immune tolerance against pancreatic cancer." @default.
- W2894747471 created "2018-10-12" @default.
- W2894747471 creator A5002536370 @default.
- W2894747471 creator A5011832960 @default.
- W2894747471 creator A5035695627 @default.
- W2894747471 creator A5066445933 @default.
- W2894747471 creator A5070893429 @default.
- W2894747471 date "2018-10-01" @default.
- W2894747471 modified "2023-10-01" @default.
- W2894747471 title "Pancreatic-cancer-cell-derived trefoil factor 2 impairs maturation and migration of human monocyte-derived dendritic cells in vitro" @default.
- W2894747471 cites W1498013762 @default.
- W2894747471 cites W1544483478 @default.
- W2894747471 cites W1563051276 @default.
- W2894747471 cites W157327218 @default.
- W2894747471 cites W1601383153 @default.
- W2894747471 cites W1661544713 @default.
- W2894747471 cites W1960538598 @default.
- W2894747471 cites W1979724209 @default.
- W2894747471 cites W1982282184 @default.
- W2894747471 cites W1983515757 @default.
- W2894747471 cites W1985852759 @default.
- W2894747471 cites W1993604578 @default.
- W2894747471 cites W1996667997 @default.
- W2894747471 cites W2004215491 @default.
- W2894747471 cites W2029841674 @default.
- W2894747471 cites W2033172475 @default.
- W2894747471 cites W2033937518 @default.
- W2894747471 cites W2036270347 @default.
- W2894747471 cites W2039613171 @default.
- W2894747471 cites W2039953594 @default.
- W2894747471 cites W2042699283 @default.
- W2894747471 cites W2044661558 @default.
- W2894747471 cites W2045828366 @default.
- W2894747471 cites W2046341726 @default.
- W2894747471 cites W2054373401 @default.
- W2894747471 cites W2060827364 @default.
- W2894747471 cites W2061784745 @default.
- W2894747471 cites W2066013154 @default.
- W2894747471 cites W2083210466 @default.
- W2894747471 cites W2094497703 @default.
- W2894747471 cites W2101345940 @default.
- W2894747471 cites W2103679122 @default.
- W2894747471 cites W2108972938 @default.
- W2894747471 cites W2111220263 @default.
- W2894747471 cites W2113411834 @default.
- W2894747471 cites W2122683221 @default.
- W2894747471 cites W2123149440 @default.
- W2894747471 cites W2129176863 @default.
- W2894747471 cites W2132106534 @default.
- W2894747471 cites W2137425487 @default.
- W2894747471 cites W2138014790 @default.
- W2894747471 cites W2149464247 @default.
- W2894747471 cites W2158537388 @default.
- W2894747471 cites W2160697532 @default.
- W2894747471 cites W2169146805 @default.
- W2894747471 cites W2339053999 @default.
- W2894747471 cites W2409312427 @default.
- W2894747471 cites W2492016684 @default.
- W2894747471 cites W2511899485 @default.
- W2894747471 cites W2736312236 @default.
- W2894747471 cites W2755704551 @default.
- W2894747471 cites W2768923525 @default.
- W2894747471 cites W4231031590 @default.
- W2894747471 cites W4245344895 @default.
- W2894747471 cites W78581478 @default.
- W2894747471 doi "https://doi.org/10.1080/19768354.2018.1527721" @default.
- W2894747471 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6282439" @default.
- W2894747471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30533259" @default.
- W2894747471 hasPublicationYear "2018" @default.
- W2894747471 type Work @default.
- W2894747471 sameAs 2894747471 @default.
- W2894747471 citedByCount "9" @default.
- W2894747471 countsByYear W28947474712019 @default.
- W2894747471 countsByYear W28947474712020 @default.
- W2894747471 countsByYear W28947474712021 @default.
- W2894747471 countsByYear W28947474712022 @default.
- W2894747471 countsByYear W28947474712023 @default.
- W2894747471 crossrefType "journal-article" @default.
- W2894747471 hasAuthorship W2894747471A5002536370 @default.
- W2894747471 hasAuthorship W2894747471A5011832960 @default.
- W2894747471 hasAuthorship W2894747471A5035695627 @default.
- W2894747471 hasAuthorship W2894747471A5066445933 @default.
- W2894747471 hasAuthorship W2894747471A5070893429 @default.
- W2894747471 hasBestOaLocation W28947474711 @default.
- W2894747471 hasConcept C121608353 @default.
- W2894747471 hasConcept C13373296 @default.
- W2894747471 hasConcept C203014093 @default.
- W2894747471 hasConcept C2776107976 @default.
- W2894747471 hasConcept C2778690821 @default.
- W2894747471 hasConcept C2780210213 @default.
- W2894747471 hasConcept C2781184567 @default.
- W2894747471 hasConcept C502942594 @default.
- W2894747471 hasConcept C54355233 @default.
- W2894747471 hasConcept C86803240 @default.
- W2894747471 hasConcept C8891405 @default.
- W2894747471 hasConcept C95444343 @default.
- W2894747471 hasConcept C96232424 @default.
- W2894747471 hasConceptScore W2894747471C121608353 @default.