Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894748679> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2894748679 abstract "Propranolol, a beta-adrenergic receptor blocker, is presently considered to be a potential therapeutic intervention under investigation for its role in prevention and treatment of osteoporosis. However, no studies have compared the osteoprotective properties of propranolol with well accepted therapeu-tic interventions for the treatment of osteoporosis. To address this question, this study was designed to evaluate the bone protective effects of zoledronic acid, alfacalcidol and propranolol in an animal model of postmenopausal osteoporosis. Five days after ovariectomy, 36 ovariectomized (OVX) rats were divided in-to 6 equal groups, randomized to treatments zoledronic acid (100 μg/kg, intravenous single dose); alfacal-cidol (0.5 μg/kg, oral gauge daily); propranolol (0.1mg/kg, subcutaneously 5 days per week) for 12 weeks. Untreated OVX and sham OVX were used as controls. At the end of the study, rats were killed under anesthesia. For bone porosity evaluation, whole fourth lumbar vertebrae (LV4) were removed. LV4 were also used to measure bone mechanical propeties. Left femurs were used for bone histology. Propranolol showed a significant decrease in bone porosity in comparison to OVX control. Moreover, propranolol sig-nificantly improved bone mechanical properties and bone quality when compared with OVX control. The osteoprotective effect of propranolol was comparable with zoledronic acid and alfacalcidol. Based on this comparative study, the results strongly suggest that propranolol might be new therapeutic intervention for the management of postmenopausal osteoporosis in humans." @default.
- W2894748679 created "2018-10-12" @default.
- W2894748679 creator A5027082048 @default.
- W2894748679 creator A5027900370 @default.
- W2894748679 creator A5043325146 @default.
- W2894748679 creator A5049934921 @default.
- W2894748679 creator A5055860673 @default.
- W2894748679 date "2013-01-01" @default.
- W2894748679 modified "2023-09-28" @default.
- W2894748679 title "Comparative Evaluation of Zoledronic Acid, Alfacalcidol and Propranolol in Pharmacological Correction of Experimental Osteoporosis" @default.
- W2894748679 hasPublicationYear "2013" @default.
- W2894748679 type Work @default.
- W2894748679 sameAs 2894748679 @default.
- W2894748679 citedByCount "3" @default.
- W2894748679 countsByYear W28947486792014 @default.
- W2894748679 countsByYear W28947486792017 @default.
- W2894748679 countsByYear W28947486792018 @default.
- W2894748679 crossrefType "journal-article" @default.
- W2894748679 hasAuthorship W2894748679A5027082048 @default.
- W2894748679 hasAuthorship W2894748679A5027900370 @default.
- W2894748679 hasAuthorship W2894748679A5043325146 @default.
- W2894748679 hasAuthorship W2894748679A5049934921 @default.
- W2894748679 hasAuthorship W2894748679A5055860673 @default.
- W2894748679 hasConcept C126322002 @default.
- W2894748679 hasConcept C126894567 @default.
- W2894748679 hasConcept C134018914 @default.
- W2894748679 hasConcept C170033053 @default.
- W2894748679 hasConcept C2776326535 @default.
- W2894748679 hasConcept C2776541429 @default.
- W2894748679 hasConcept C2776886416 @default.
- W2894748679 hasConcept C2777164284 @default.
- W2894748679 hasConcept C2778151854 @default.
- W2894748679 hasConcept C2779126354 @default.
- W2894748679 hasConcept C71924100 @default.
- W2894748679 hasConcept C8264082 @default.
- W2894748679 hasConceptScore W2894748679C126322002 @default.
- W2894748679 hasConceptScore W2894748679C126894567 @default.
- W2894748679 hasConceptScore W2894748679C134018914 @default.
- W2894748679 hasConceptScore W2894748679C170033053 @default.
- W2894748679 hasConceptScore W2894748679C2776326535 @default.
- W2894748679 hasConceptScore W2894748679C2776541429 @default.
- W2894748679 hasConceptScore W2894748679C2776886416 @default.
- W2894748679 hasConceptScore W2894748679C2777164284 @default.
- W2894748679 hasConceptScore W2894748679C2778151854 @default.
- W2894748679 hasConceptScore W2894748679C2779126354 @default.
- W2894748679 hasConceptScore W2894748679C71924100 @default.
- W2894748679 hasConceptScore W2894748679C8264082 @default.
- W2894748679 hasLocation W28947486791 @default.
- W2894748679 hasOpenAccess W2894748679 @default.
- W2894748679 hasPrimaryLocation W28947486791 @default.
- W2894748679 hasRelatedWork W1517735842 @default.
- W2894748679 hasRelatedWork W1980154423 @default.
- W2894748679 hasRelatedWork W1986243497 @default.
- W2894748679 hasRelatedWork W1993035292 @default.
- W2894748679 hasRelatedWork W2020911258 @default.
- W2894748679 hasRelatedWork W2045408633 @default.
- W2894748679 hasRelatedWork W2054138009 @default.
- W2894748679 hasRelatedWork W2062403630 @default.
- W2894748679 hasRelatedWork W2082125497 @default.
- W2894748679 hasRelatedWork W2117042230 @default.
- W2894748679 hasRelatedWork W2117203233 @default.
- W2894748679 hasRelatedWork W2120905001 @default.
- W2894748679 hasRelatedWork W2154478484 @default.
- W2894748679 hasRelatedWork W2166765762 @default.
- W2894748679 hasRelatedWork W2348013337 @default.
- W2894748679 hasRelatedWork W2357264652 @default.
- W2894748679 hasRelatedWork W2474546760 @default.
- W2894748679 hasRelatedWork W2907201640 @default.
- W2894748679 hasRelatedWork W2913449552 @default.
- W2894748679 hasRelatedWork W3189119377 @default.
- W2894748679 isParatext "false" @default.
- W2894748679 isRetracted "false" @default.
- W2894748679 magId "2894748679" @default.
- W2894748679 workType "article" @default.