Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894763287> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2894763287 abstract "To date, studies on mesenchymal tissue stem cells (MSCs) in the perichondrium have focused on in vitro analysis, and the dynamics of cartilage regeneration from the perichondrium in vivo remain largely unknown. We have attempted to apply cell and tissue engineering methodology for ear reconstruction using cultured chondrocytes. We hypothesized that by inducing angiogenesis with basic fibroblast growth factor (bFGF), MSCs or cartilage precursor cells would proliferate and differentiate into cartilage in vivo and that the regenerated cartilage would maintain its morphology over an extended period. As a result of a single administration of bFGF to the perichondrium, cartilage tissue formed and proliferated while maintaining its morphology for at least 3 months. By day 3 post bFGF treatment, inflammatory cells, primarily comprising mononuclear cells, migrated to the perichondrial region, and the proliferation of matrix metalloproteinase 1 positive cells peaked. During week 1, the perichondrium thickened and proliferation of vascular endothelial cells was noted, along with an increase in the number of CD44-positive and CD90-positive cartilage MSCs/progenitor cells. Neocartilage was formed after 2 weeks, and hypertrophied mature cartilage was formed and maintained after 3 months. Proliferation of the perichondrium and cartilage was bFGF concentration-dependent and was inhibited by neutralizing antibodies. Angiogenesis induction by bFGF was blocked by the administration of an angiogenesis inhibitor, preventing perichondrium proliferation and neocartilage formation. These results suggested that angiogenesis may be important for the induction and differentiation of MSCs/cartilage precursor cells in vivo, and that morphological changes, once occurring, are maintained." @default.
- W2894763287 created "2018-10-12" @default.
- W2894763287 creator A5008282193 @default.
- W2894763287 creator A5034991382 @default.
- W2894763287 creator A5044238752 @default.
- W2894763287 creator A5051109631 @default.
- W2894763287 creator A5075094586 @default.
- W2894763287 date "2018-10-05" @default.
- W2894763287 modified "2023-09-24" @default.
- W2894763287 title "Angiogenesis after administration of basic fibroblast growth factor induces proliferation and differentiation of mesenchymal stem cells in elastic perichondrium in an in vivo model: mini review of three sequential republication-abridged reports" @default.
- W2894763287 cites W1970407695 @default.
- W2894763287 cites W1990653503 @default.
- W2894763287 cites W2006875892 @default.
- W2894763287 cites W2024787221 @default.
- W2894763287 cites W2028704032 @default.
- W2894763287 cites W2043245072 @default.
- W2894763287 cites W2063352721 @default.
- W2894763287 cites W2088307350 @default.
- W2894763287 cites W2089753144 @default.
- W2894763287 cites W2114024295 @default.
- W2894763287 cites W2123400942 @default.
- W2894763287 cites W2127640925 @default.
- W2894763287 cites W2160499661 @default.
- W2894763287 cites W2170425752 @default.
- W2894763287 cites W2170634501 @default.
- W2894763287 cites W2227965385 @default.
- W2894763287 cites W2336271365 @default.
- W2894763287 doi "https://doi.org/10.1186/s11658-018-0113-1" @default.
- W2894763287 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6173837" @default.
- W2894763287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30323846" @default.
- W2894763287 hasPublicationYear "2018" @default.
- W2894763287 type Work @default.
- W2894763287 sameAs 2894763287 @default.
- W2894763287 citedByCount "12" @default.
- W2894763287 countsByYear W28947632872018 @default.
- W2894763287 countsByYear W28947632872019 @default.
- W2894763287 countsByYear W28947632872020 @default.
- W2894763287 countsByYear W28947632872021 @default.
- W2894763287 countsByYear W28947632872022 @default.
- W2894763287 countsByYear W28947632872023 @default.
- W2894763287 crossrefType "journal-article" @default.
- W2894763287 hasAuthorship W2894763287A5008282193 @default.
- W2894763287 hasAuthorship W2894763287A5034991382 @default.
- W2894763287 hasAuthorship W2894763287A5044238752 @default.
- W2894763287 hasAuthorship W2894763287A5051109631 @default.
- W2894763287 hasAuthorship W2894763287A5075094586 @default.
- W2894763287 hasBestOaLocation W28947632871 @default.
- W2894763287 hasConcept C105702510 @default.
- W2894763287 hasConcept C170493617 @default.
- W2894763287 hasConcept C185592680 @default.
- W2894763287 hasConcept C198826908 @default.
- W2894763287 hasConcept C203014093 @default.
- W2894763287 hasConcept C25515809 @default.
- W2894763287 hasConcept C2775960820 @default.
- W2894763287 hasConcept C2777587049 @default.
- W2894763287 hasConcept C2780394083 @default.
- W2894763287 hasConcept C2780550940 @default.
- W2894763287 hasConcept C502942594 @default.
- W2894763287 hasConcept C55493867 @default.
- W2894763287 hasConcept C86803240 @default.
- W2894763287 hasConcept C95444343 @default.
- W2894763287 hasConceptScore W2894763287C105702510 @default.
- W2894763287 hasConceptScore W2894763287C170493617 @default.
- W2894763287 hasConceptScore W2894763287C185592680 @default.
- W2894763287 hasConceptScore W2894763287C198826908 @default.
- W2894763287 hasConceptScore W2894763287C203014093 @default.
- W2894763287 hasConceptScore W2894763287C25515809 @default.
- W2894763287 hasConceptScore W2894763287C2775960820 @default.
- W2894763287 hasConceptScore W2894763287C2777587049 @default.
- W2894763287 hasConceptScore W2894763287C2780394083 @default.
- W2894763287 hasConceptScore W2894763287C2780550940 @default.
- W2894763287 hasConceptScore W2894763287C502942594 @default.
- W2894763287 hasConceptScore W2894763287C55493867 @default.
- W2894763287 hasConceptScore W2894763287C86803240 @default.
- W2894763287 hasConceptScore W2894763287C95444343 @default.
- W2894763287 hasFunder F4320334764 @default.
- W2894763287 hasIssue "1" @default.
- W2894763287 hasLocation W28947632871 @default.
- W2894763287 hasLocation W28947632872 @default.
- W2894763287 hasLocation W28947632873 @default.
- W2894763287 hasLocation W28947632874 @default.
- W2894763287 hasOpenAccess W2894763287 @default.
- W2894763287 hasPrimaryLocation W28947632871 @default.
- W2894763287 hasRelatedWork W1973071167 @default.
- W2894763287 hasRelatedWork W2024950521 @default.
- W2894763287 hasRelatedWork W2027216690 @default.
- W2894763287 hasRelatedWork W2045986059 @default.
- W2894763287 hasRelatedWork W2056680337 @default.
- W2894763287 hasRelatedWork W2059583217 @default.
- W2894763287 hasRelatedWork W2123800132 @default.
- W2894763287 hasRelatedWork W2125661032 @default.
- W2894763287 hasRelatedWork W2784248538 @default.
- W2894763287 hasRelatedWork W3024723200 @default.
- W2894763287 hasVolume "23" @default.
- W2894763287 isParatext "false" @default.
- W2894763287 isRetracted "false" @default.
- W2894763287 magId "2894763287" @default.
- W2894763287 workType "article" @default.