FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894764145> ?p ?o ?g. }

• W2894764145 endingPage "365" @default.
• W2894764145 startingPage "356" @default.
• W2894764145 abstract "It is the goal for the development of cancer target chemotherapy with specific recognition, efficient killing the tumor cells and tissues to avoid the intolerable side effects. Molecular imprinted polymer (MIPs) nanoparticles could introduce kinds of specific bio-markers (template molecules) into the nanoparticles with the subsequent removal, leaving special holes in the structure with predictable recognition specificity with cells. Herein, we design and synthesize a kind of sialic acid (SA) over-expressed tumor target hollow double-layer imprinted polymer nanoparticles with S-nitrosothiols for nitric oxide (NO)-releasing as chemotherapy. Equilibrium/selective bindings properties and probe experimental results implies that the MIPs have an intelligently selective binding to cancer cells featuring high levels of SA glyans, providing precondition for the disulfide polymer assisted cell uptake, intracellular GSH induced decomposition and rapid NO-releasing. Cytotoxicity assay with kinds of cells demonstrates the intelligent in vitro SA over-expressed tumor cells targeting recognition, intracellular delivery and cytotoxicity. In vivo bio-distribution in tumor sites and major organs, significant suppression of tumor growth, tumor-bearing mice survival unit, and the systemic toxicity investigation experiments confirm the effective chemotherapy of the S-nitrosothiols MIPs nanoparticles for the target recognition and the controlled NO release for tumor treatment comparing to the results with S-nitrosothiols CPs as delivery system. The inevitable small amount of NO leakage from S-nitrosothiols MIPs would take part in normal physiological activities and not cause serious side effects. For the first time, this kind of nitric oxide based chemotherapy and molecular-imprinting cell recognition technique both in vitro and in vivo, might provide a solution for accurate therapy to various forms of cancer with specific markers and avoid the intolerable side effects of the traditional chemotherapy treatment." @default.
• W2894764145 created "2018-10-12" @default.
• W2894764145 creator A5006833948 @default.
• W2894764145 creator A5048192485 @default.
• W2894764145 creator A5055151897 @default.
• W2894764145 creator A5061651730 @default.
• W2894764145 creator A5066472833 @default.
• W2894764145 creator A5085695725 @default.
• W2894764145 creator A5090772939 @default.
• W2894764145 date "2019-01-01" @default.
• W2894764145 modified "2023-10-17" @default.
• W2894764145 title "Molecular imprinted S-nitrosothiols nanoparticles for nitric oxide control release as cancer target chemotherapy" @default.
• W2894764145 cites W1156966783 @default.
• W2894764145 cites W1269597682 @default.
• W2894764145 cites W1890443124 @default.
• W2894764145 cites W1917033115 @default.
• W2894764145 cites W1934064847 @default.
• W2894764145 cites W1963840921 @default.
• W2894764145 cites W1965324658 @default.
• W2894764145 cites W1967907911 @default.
• W2894764145 cites W1980640822 @default.
• W2894764145 cites W1985289402 @default.
• W2894764145 cites W1989767588 @default.
• W2894764145 cites W1992377163 @default.
• W2894764145 cites W1992542606 @default.
• W2894764145 cites W1992900472 @default.
• W2894764145 cites W2003158550 @default.
• W2894764145 cites W2003559464 @default.
• W2894764145 cites W2007838251 @default.
• W2894764145 cites W2009117616 @default.
• W2894764145 cites W2009716635 @default.
• W2894764145 cites W2011079540 @default.
• W2894764145 cites W2012245293 @default.
• W2894764145 cites W2026954356 @default.
• W2894764145 cites W2030710974 @default.
• W2894764145 cites W2034724794 @default.
• W2894764145 cites W2044516495 @default.
• W2894764145 cites W2046914021 @default.
• W2894764145 cites W2048039577 @default.
• W2894764145 cites W2049259181 @default.
• W2894764145 cites W2049307465 @default.
• W2894764145 cites W2054558479 @default.
• W2894764145 cites W2055309775 @default.
• W2894764145 cites W2055991021 @default.
• W2894764145 cites W2063600933 @default.
• W2894764145 cites W2068307249 @default.
• W2894764145 cites W2073617279 @default.
• W2894764145 cites W2075567991 @default.
• W2894764145 cites W2077343603 @default.
• W2894764145 cites W2079259006 @default.
• W2894764145 cites W2081952060 @default.
• W2894764145 cites W2083663368 @default.
• W2894764145 cites W2098652851 @default.
• W2894764145 cites W2100174417 @default.
• W2894764145 cites W2121588632 @default.
• W2894764145 cites W2133061394 @default.
• W2894764145 cites W2160943954 @default.
• W2894764145 cites W2161920392 @default.
• W2894764145 cites W2169560941 @default.
• W2894764145 cites W2218788548 @default.
• W2894764145 cites W2261220794 @default.
• W2894764145 cites W2286994628 @default.
• W2894764145 cites W2312317278 @default.
• W2894764145 cites W2314461424 @default.
• W2894764145 cites W2314723437 @default.
• W2894764145 cites W2318726238 @default.
• W2894764145 cites W2321616752 @default.
• W2894764145 cites W2321913191 @default.
• W2894764145 cites W2327512321 @default.
• W2894764145 cites W2330845296 @default.
• W2894764145 cites W2406107447 @default.
• W2894764145 cites W2409299056 @default.
• W2894764145 cites W2512430192 @default.
• W2894764145 cites W2515800095 @default.
• W2894764145 cites W2550410232 @default.
• W2894764145 cites W2568562742 @default.
• W2894764145 cites W2598282456 @default.
• W2894764145 cites W2746315943 @default.
• W2894764145 cites W2777760019 @default.
• W2894764145 cites W2790228691 @default.
• W2894764145 cites W2790551110 @default.
• W2894764145 cites W2792975649 @default.
• W2894764145 doi "https://doi.org/10.1016/j.colsurfb.2018.09.078" @default.
• W2894764145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30316082" @default.
• W2894764145 hasPublicationYear "2019" @default.
• W2894764145 type Work @default.
• W2894764145 sameAs 2894764145 @default.
• W2894764145 citedByCount "30" @default.
• W2894764145 countsByYear W28947641452019 @default.
• W2894764145 countsByYear W28947641452020 @default.
• W2894764145 countsByYear W28947641452021 @default.
• W2894764145 countsByYear W28947641452022 @default.
• W2894764145 countsByYear W28947641452023 @default.
• W2894764145 crossrefType "journal-article" @default.
• W2894764145 hasAuthorship W2894764145A5006833948 @default.
• W2894764145 hasAuthorship W2894764145A5048192485 @default.
• W2894764145 hasAuthorship W2894764145A5055151897 @default.
• W2894764145 hasAuthorship W2894764145A5061651730 @default.

• next