FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894766895> ?p ?o ?g. }

• W2894766895 endingPage "12" @default.
• W2894766895 startingPage "1" @default.
• W2894766895 abstract "Thymic stromal lymphopoietin (TSLP) is a cytokine expressed in the epithelium, involved in the pathogenesis of chronic disease. IL-17A regulates airway inflammation, oxidative stress, and reduction of steroid sensitivity in chronic obstructive pulmonary disease (COPD). TSLP and IL-17A were measured in induced sputum supernatants (ISs) from healthy controls (HC), healthy smokers (HS), and COPD patients by enzyme-linked immunosorbent assay. Human bronchial epithelial cell line (16HBE) and normal bronchial epithelial cells were stimulated with rhIL-17A or ISs from COPD patients to evaluate TSLP protein and mRNA expression. The effects of the depletion of IL-17A in ISs, an anticholinergic drug, and the silencing of inhibitor kappa kinase alpha (IKKα) on TSLP production were evaluated in 16HBE cells. Coimmunoprecipitation of acetyl-histone H3(Lys14)/IKKα was evaluated in 16HBE cells treated with rhIL-17A and in the presence of the drug. TSLP and IL-17A levels were higher in ISs from COPD patients and HS compared with HC. TSLP protein and mRNA increased in 16HBE cells and in normal bronchial epithelial cells stimulated with ISs from COPD patients compared with ISs from HC and untreated cells. IKKα silencing reduced TSLP production in 16HBE cells stimulated with rhIL-17A and ISs from COPD patients. RhIL-17A increased the IKKα/acetyl-histone H3 immunoprecipitation in 16HBE cells. The anticholinergic drug affects TSLP protein and mRNA levels in bronchial epithelial cells treated with rhIL-17A or with ISs from COPD patients, and IKKα mediated acetyl-histone H3(Lys14). IL-17A/IKKα signaling induced the mechanism of chromatin remodeling associated with acetyl-histone H3(Lys14) and TSLP production in bronchial epithelial cells. Anticholinergic drugs might target TSLP derived from epithelial cells during the treatment of COPD." @default.
• W2894766895 created "2018-10-12" @default.
• W2894766895 creator A5008797235 @default.
• W2894766895 creator A5025169554 @default.
• W2894766895 creator A5029667558 @default.
• W2894766895 creator A5032482241 @default.
• W2894766895 creator A5038512519 @default.
• W2894766895 creator A5064486570 @default.
• W2894766895 creator A5066244090 @default.
• W2894766895 creator A5072006204 @default.
• W2894766895 creator A5076598691 @default.
• W2894766895 creator A5086345118 @default.
• W2894766895 date "2018-10-01" @default.
• W2894766895 modified "2023-10-11" @default.
• W2894766895 title "IL-17A-associated IKK-α signaling induced TSLP production in epithelial cells of COPD patients" @default.
• W2894766895 cites W1034171487 @default.
• W2894766895 cites W1551139678 @default.
• W2894766895 cites W1912696051 @default.
• W2894766895 cites W1976310141 @default.
• W2894766895 cites W1982776595 @default.
• W2894766895 cites W1991380818 @default.
• W2894766895 cites W1999177172 @default.
• W2894766895 cites W2004186675 @default.
• W2894766895 cites W2011811265 @default.
• W2894766895 cites W2022751366 @default.
• W2894766895 cites W2041550275 @default.
• W2894766895 cites W2042347466 @default.
• W2894766895 cites W2044433987 @default.
• W2894766895 cites W2045463226 @default.
• W2894766895 cites W2045616259 @default.
• W2894766895 cites W2047474767 @default.
• W2894766895 cites W2051659559 @default.
• W2894766895 cites W2053798956 @default.
• W2894766895 cites W2063211760 @default.
• W2894766895 cites W2072196657 @default.
• W2894766895 cites W2077917566 @default.
• W2894766895 cites W2093713190 @default.
• W2894766895 cites W2094863064 @default.
• W2894766895 cites W2098781159 @default.
• W2894766895 cites W2099519303 @default.
• W2894766895 cites W2100453211 @default.
• W2894766895 cites W2122128999 @default.
• W2894766895 cites W2125421373 @default.
• W2894766895 cites W2125525438 @default.
• W2894766895 cites W2142772794 @default.
• W2894766895 cites W2144266634 @default.
• W2894766895 cites W2148939316 @default.
• W2894766895 cites W2151041131 @default.
• W2894766895 cites W2162803006 @default.
• W2894766895 cites W2165176539 @default.
• W2894766895 cites W2166774750 @default.
• W2894766895 cites W2170016854 @default.
• W2894766895 cites W2293167352 @default.
• W2894766895 cites W2327826619 @default.
• W2894766895 cites W2604165347 @default.
• W2894766895 doi "https://doi.org/10.1038/s12276-018-0158-2" @default.
• W2894766895 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6173689" @default.
• W2894766895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30291224" @default.
• W2894766895 hasPublicationYear "2018" @default.
• W2894766895 type Work @default.
• W2894766895 sameAs 2894766895 @default.
• W2894766895 citedByCount "15" @default.
• W2894766895 countsByYear W28947668952019 @default.
• W2894766895 countsByYear W28947668952020 @default.
• W2894766895 countsByYear W28947668952021 @default.
• W2894766895 countsByYear W28947668952022 @default.
• W2894766895 countsByYear W28947668952023 @default.
• W2894766895 crossrefType "journal-article" @default.
• W2894766895 hasAuthorship W2894766895A5008797235 @default.
• W2894766895 hasAuthorship W2894766895A5025169554 @default.
• W2894766895 hasAuthorship W2894766895A5029667558 @default.
• W2894766895 hasAuthorship W2894766895A5032482241 @default.
• W2894766895 hasAuthorship W2894766895A5038512519 @default.
• W2894766895 hasAuthorship W2894766895A5064486570 @default.
• W2894766895 hasAuthorship W2894766895A5066244090 @default.
• W2894766895 hasAuthorship W2894766895A5072006204 @default.
• W2894766895 hasAuthorship W2894766895A5076598691 @default.
• W2894766895 hasAuthorship W2894766895A5086345118 @default.
• W2894766895 hasBestOaLocation W28947668951 @default.
• W2894766895 hasConcept C104317684 @default.
• W2894766895 hasConcept C119056186 @default.
• W2894766895 hasConcept C126322002 @default.
• W2894766895 hasConcept C185592680 @default.
• W2894766895 hasConcept C203014093 @default.
• W2894766895 hasConcept C2776780178 @default.
• W2894766895 hasConcept C2778070265 @default.
• W2894766895 hasConcept C2778690821 @default.
• W2894766895 hasConcept C502942594 @default.
• W2894766895 hasConcept C55493867 @default.
• W2894766895 hasConcept C71924100 @default.
• W2894766895 hasConceptScore W2894766895C104317684 @default.
• W2894766895 hasConceptScore W2894766895C119056186 @default.
• W2894766895 hasConceptScore W2894766895C126322002 @default.
• W2894766895 hasConceptScore W2894766895C185592680 @default.
• W2894766895 hasConceptScore W2894766895C203014093 @default.
• W2894766895 hasConceptScore W2894766895C2776780178 @default.
• W2894766895 hasConceptScore W2894766895C2778070265 @default.
• W2894766895 hasConceptScore W2894766895C2778690821 @default.

• next