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- W2894770088 abstract "Aim: To enhance the bioavailability of poorly water-soluble diosgenin (DG) by chitosan/BSA encapsulated nanoparticle formulation. Material and Methods: 0.1% chitosan aqueous solution was mixed with freshly prepared saturated DG solution followed by probe-sonication for 30 min., thereafter 0.1% BSA solution was added drop-wise and sonicated for another layer formation. Procedure was repeated for bilayer formation. After each layer formation nanoparticles were centrifuged and resuspended in fresh DI water. Results and Discussion: The DLS of nanosized DG shown to have a radius of 2 nm to 40 nm. Surface morphology of nanoDG has been observed using SEM. Non-significant changes under the UV/Vis and IR, suggest the retention of drug properties at nano level. Chitosan/BSA coatings generated a higher surface charge (ca. +28 mV and -30mV) resulting in good colloidal stability. Dissolution technique was used for release profiling of drug from layer-by-layer assembly. Conclusion: The combination of biocompatible ionic polymers chitosan/BSA bilayer encapsulation around nanoDG, allowed sustained release of drug molecule up to 30 hours." @default.
- W2894770088 created "2018-10-12" @default.
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- W2894770088 date "2018-06-01" @default.
- W2894770088 modified "2023-10-13" @default.
- W2894770088 doi "https://doi.org/10.22377/ajp.v12i02.2323" @default.
- W2894770088 hasPublicationYear "2018" @default.
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