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• W2894772504 abstract "Abstract Background and objectives Vitamin D deficiency has been consistently linked with cardiovascular diseases. However, results of intervention studies are contradictory. The aim of this study was to evaluate the effect of treatment with calcifediol (25(OH)D3) on the cardiovascular system of patients with non-ST-elevation acute coronary syndrome after percutaneous coronary intervention. Patients and methods A prospective study assessing ≥60-year-old patients with non-ST-elevation acute coronary syndrome, coronary artery disease and percutaneous revascularisation. We randomly assigned 41 patients (70.6 ±6.3 years) into 2 groups: Standard treatment + 25(OH)D3 supplementation or standard treatment alone. Major adverse cardiovascular events (MACE) were evaluated at the conclusion of the 3-month follow-up period. 25(OH)D levels were analyzed with regard to other relevant analytical variables and coronary disease extent. Results Basal levels of 25(OH)D ≤ 50 nmol/L were associated with multivessel coronary artery disease (RR: 2.6 [CI 95%:1.1–7.1], p =0.027) and 25(OH)D ≤ 50 nmol/L + parathormone  ≥ 65 pg/mL levels correlated with increased risk for MACE (RR: 4 [CI 95%: 1.1–21.8], p = 0.04]. One MACE was detected in the supplemented group versus five in the control group (p = 0.66). Among patients with 25(OH)D levels ≤50 nmol/L at the end of the study, 28.6% had MACE versus 0% among patients with 25(OH)D > 50 nmol/L (RR: 1,4; p = 0.037). Conclusions Vitamin D deficiency plus secondary hyperparathyroidism may be an effective predictor of MACE. A trend throughout the follow up period towards a reduction in MACE among patients supplemented with 25(OH)D3 was detected. 25(OH)D levels ≤ 50 nmol/L at the end of the intervention period were significantly associated with an increased number of MACE, hence, 25(OH)D level normalization could improve cardiovascular health in addition to bone health." @default.
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• W2894772504 date "2018-11-01" @default.
• W2894772504 modified "2023-10-16" @default.
• W2894772504 title "Effect of calcifediol treatment on cardiovascular outcomes in patients with acute coronary syndrome and percutaneous revascularization" @default.
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• W2894772504 doi "https://doi.org/10.1016/j.medcle.2018.09.001" @default.
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