Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894773629> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W2894773629 abstract "Background: Binge drinking combined with trauma is a major cause of mortality in US. It is known that acute alcohol intoxication (AAI) causes deleterious electrical changes in the heart, including involving QTc dispersion. We also recently demonstrated that acute alcohol intoxication (AAI) increases microvascular permeability. In the current study we investigated the consequences of combined hemorrhagic shock and resuscitation (HSR) and AAI on both microvascular permeability and cardiac electrical activity. Hypothesis and Methods: We hypothesized that AAI combined with HSR causes microvascular leakage and electrical dysfunction in the heart. We used an established rat model of AAI/HSR to test the microvascular and cardiac effects. Results: We identified that combined AAI/HSR significantly (p<0.0007) prolongs the QTc interval (ms) compared to control water fed, sham rats (190.8±7.1 vs. 138.4±4.4, p<0.05). Ex vivo acquired left ventricular monophasic action potential (AP) data revealed increased AP duration in the AAI/HSR group at 20 (9.7±0.6 vs. 5.5±0.2; p<0.0004 ), 50 (16±1.1 vs. 8.8±0.6; p<0.001), and 70% (24.7±2.4 vs. 19.5±0.5; p<0.03) repolarization level relative to water/sham controls. Microvascular hyperpermeability was apparent in the mesenteric microcirculation in the AAI/HSR group compared to AAI/sham, water/HSR, and water/sham controls (IOI of 1061.7±208 HSR-alcohol vs. 698.4±311 HSR-water, p<0.05; vs. 209.5±42 sham-alcohol, p<0.001; and vs. 62.3±9 sham-water, p<0.001). Conclusions: We report for the first time the cardiovascular hallmarks of AAI/HSR associated injury, which include prolonged QTc and AP durations and elevated microvascular permeability." @default.
- W2894773629 created "2018-10-12" @default.
- W2894773629 creator A5002399442 @default.
- W2894773629 creator A5019018166 @default.
- W2894773629 creator A5051164397 @default.
- W2894773629 creator A5059653668 @default.
- W2894773629 creator A5073231087 @default.
- W2894773629 creator A5090279770 @default.
- W2894773629 date "2015-11-10" @default.
- W2894773629 modified "2023-10-16" @default.
- W2894773629 title "Abstract 19945: Acute Alcohol Intoxication and Hemorrhagic Shock Lead to Microvascular Hyperpermeability and Cardiovascular Arrhythmias" @default.
- W2894773629 doi "https://doi.org/10.1161/circ.132.suppl_3.19945" @default.
- W2894773629 hasPublicationYear "2015" @default.
- W2894773629 type Work @default.
- W2894773629 sameAs 2894773629 @default.
- W2894773629 citedByCount "0" @default.
- W2894773629 crossrefType "journal-article" @default.
- W2894773629 hasAuthorship W2894773629A5002399442 @default.
- W2894773629 hasAuthorship W2894773629A5019018166 @default.
- W2894773629 hasAuthorship W2894773629A5051164397 @default.
- W2894773629 hasAuthorship W2894773629A5059653668 @default.
- W2894773629 hasAuthorship W2894773629A5073231087 @default.
- W2894773629 hasAuthorship W2894773629A5090279770 @default.
- W2894773629 hasConcept C126322002 @default.
- W2894773629 hasConcept C12722491 @default.
- W2894773629 hasConcept C146403970 @default.
- W2894773629 hasConcept C164705383 @default.
- W2894773629 hasConcept C185263204 @default.
- W2894773629 hasConcept C2781300812 @default.
- W2894773629 hasConcept C42219234 @default.
- W2894773629 hasConcept C71924100 @default.
- W2894773629 hasConceptScore W2894773629C126322002 @default.
- W2894773629 hasConceptScore W2894773629C12722491 @default.
- W2894773629 hasConceptScore W2894773629C146403970 @default.
- W2894773629 hasConceptScore W2894773629C164705383 @default.
- W2894773629 hasConceptScore W2894773629C185263204 @default.
- W2894773629 hasConceptScore W2894773629C2781300812 @default.
- W2894773629 hasConceptScore W2894773629C42219234 @default.
- W2894773629 hasConceptScore W2894773629C71924100 @default.
- W2894773629 hasIssue "suppl_3" @default.
- W2894773629 hasLocation W28947736291 @default.
- W2894773629 hasOpenAccess W2894773629 @default.
- W2894773629 hasPrimaryLocation W28947736291 @default.
- W2894773629 hasRelatedWork W2011347913 @default.
- W2894773629 hasRelatedWork W2049397185 @default.
- W2894773629 hasRelatedWork W2073151595 @default.
- W2894773629 hasRelatedWork W2074833529 @default.
- W2894773629 hasRelatedWork W2125804349 @default.
- W2894773629 hasRelatedWork W2159512267 @default.
- W2894773629 hasRelatedWork W2170431845 @default.
- W2894773629 hasRelatedWork W2304633692 @default.
- W2894773629 hasRelatedWork W2355498105 @default.
- W2894773629 hasRelatedWork W2399063111 @default.
- W2894773629 hasVolume "132" @default.
- W2894773629 isParatext "false" @default.
- W2894773629 isRetracted "false" @default.
- W2894773629 magId "2894773629" @default.
- W2894773629 workType "article" @default.