FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894776925> ?p ?o ?g. }

• W2894776925 endingPage "209" @default.
• W2894776925 startingPage "199" @default.
• W2894776925 abstract "Macrophages are versatile phagocytic cells in immune system with immunoregulatory functions. However, the removal of apoptotic cells by macrophages is disturbed in systemic lupus erythematosus (SLE). Aryl hydrocarbon receptor (AhR) is a ligand-activated cytoplasmic receptor and transcription factor with diverse effects on immune response. Indole-3-carbinol (I3C) is an AhR agonist which has been implicated as a beneficial factor in regulating inflammation and cytokine expression in murine models of SLE. However, the molecular mechanisms are not thoroughly studied. Here, we aimed to investigate the ex vivo effects of I3C on polarization of monocyte-derived macrophages (MDMs) in SLE patients and the expression of regulatory cytokines upon AhR activation. MDMs from 15 newly diagnosed SLE patients and 10 normal subjects were induced by Jurkat apoptotic bodies (JABs) and treated with I3C. I3C enhanced the nuclear accumulation of AhR among MDMs of SLE patients and altered the expression of AhR target genes including CYP1A1, IL1- β, IDO-1 and MRC-1. The imbalanced expression of pro- and anti- inflammatory cytokines (IL-10, IL-12, TGFβ1, TNFα, IL-23, IL-6 and IFN-γ) was compensated in response to I3C. AhR activation was also associated with the overexpression of M2 markers (CD163) and downregulation of M1 markers (CD86). Thus, macrophages are activated alternatively in response to I3C. The obtained data indicate that I3C-mediated AhR activation possess immunoregulatory effects on macrophages of SLE patients by exerting an obvious downregulation in the expression of pro-inflammatory and overexpression of anti-inflammatory cytokines. Therefore, AhR could be targeted and further investigated as a choice of anti-inflammatory therapies for autoimmune disorders such as SLE." @default.
• W2894776925 created "2018-10-12" @default.
• W2894776925 creator A5014140976 @default.
• W2894776925 creator A5019504935 @default.
• W2894776925 creator A5040782517 @default.
• W2894776925 creator A5041645473 @default.
• W2894776925 creator A5077028118 @default.
• W2894776925 date "2018-07-04" @default.
• W2894776925 modified "2023-10-16" @default.
• W2894776925 title "Immunoregulatory effects of indole-3-carbinol on monocyte-derived macrophages in systemic lupus erythematosus: A crucial role for <i>aryl hydrocarbon receptor</i>" @default.
• W2894776925 cites W1963980951 @default.
• W2894776925 cites W1967763945 @default.
• W2894776925 cites W1968558968 @default.
• W2894776925 cites W1968845100 @default.
• W2894776925 cites W1973953415 @default.
• W2894776925 cites W1978678681 @default.
• W2894776925 cites W1986480779 @default.
• W2894776925 cites W1990396303 @default.
• W2894776925 cites W1993116843 @default.
• W2894776925 cites W1996613294 @default.
• W2894776925 cites W2004522121 @default.
• W2894776925 cites W2008343182 @default.
• W2894776925 cites W2009170266 @default.
• W2894776925 cites W2022246658 @default.
• W2894776925 cites W2024588239 @default.
• W2894776925 cites W2038689279 @default.
• W2894776925 cites W2056067227 @default.
• W2894776925 cites W2060645387 @default.
• W2894776925 cites W2065505163 @default.
• W2894776925 cites W2070855360 @default.
• W2894776925 cites W2071775980 @default.
• W2894776925 cites W2073021729 @default.
• W2894776925 cites W2078918202 @default.
• W2894776925 cites W2083294746 @default.
• W2894776925 cites W2083767788 @default.
• W2894776925 cites W2093705034 @default.
• W2894776925 cites W2094887438 @default.
• W2894776925 cites W2095948938 @default.
• W2894776925 cites W2097615954 @default.
• W2894776925 cites W2113949094 @default.
• W2894776925 cites W2115027742 @default.
• W2894776925 cites W2116652131 @default.
• W2894776925 cites W2119478254 @default.
• W2894776925 cites W2119566474 @default.
• W2894776925 cites W2122957912 @default.
• W2894776925 cites W2129168050 @default.
• W2894776925 cites W2136855276 @default.
• W2894776925 cites W2140380746 @default.
• W2894776925 cites W2148196931 @default.
• W2894776925 cites W2151683706 @default.
• W2894776925 cites W2159560463 @default.
• W2894776925 cites W2280518457 @default.
• W2894776925 cites W2345616360 @default.
• W2894776925 cites W2546587401 @default.
• W2894776925 cites W2605198180 @default.
• W2894776925 cites W2609237754 @default.
• W2894776925 cites W2623795052 @default.
• W2894776925 cites W2744612016 @default.
• W2894776925 cites W2749445441 @default.
• W2894776925 cites W2754961031 @default.
• W2894776925 cites W2800526280 @default.
• W2894776925 doi "https://doi.org/10.1080/08916934.2018.1494161" @default.
• W2894776925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30289282" @default.
• W2894776925 hasPublicationYear "2018" @default.
• W2894776925 type Work @default.
• W2894776925 sameAs 2894776925 @default.
• W2894776925 citedByCount "44" @default.
• W2894776925 countsByYear W28947769252018 @default.
• W2894776925 countsByYear W28947769252019 @default.
• W2894776925 countsByYear W28947769252020 @default.
• W2894776925 countsByYear W28947769252021 @default.
• W2894776925 countsByYear W28947769252022 @default.
• W2894776925 countsByYear W28947769252023 @default.
• W2894776925 crossrefType "journal-article" @default.
• W2894776925 hasAuthorship W2894776925A5014140976 @default.
• W2894776925 hasAuthorship W2894776925A5019504935 @default.
• W2894776925 hasAuthorship W2894776925A5040782517 @default.
• W2894776925 hasAuthorship W2894776925A5041645473 @default.
• W2894776925 hasAuthorship W2894776925A5077028118 @default.
• W2894776925 hasConcept C104317684 @default.
• W2894776925 hasConcept C127561419 @default.
• W2894776925 hasConcept C164027704 @default.
• W2894776925 hasConcept C170493617 @default.
• W2894776925 hasConcept C179464577 @default.
• W2894776925 hasConcept C17991360 @default.
• W2894776925 hasConcept C185592680 @default.
• W2894776925 hasConcept C203014093 @default.
• W2894776925 hasConcept C2776090121 @default.
• W2894776925 hasConcept C2776914184 @default.
• W2894776925 hasConcept C2778690821 @default.
• W2894776925 hasConcept C2781184567 @default.
• W2894776925 hasConcept C33594762 @default.
• W2894776925 hasConcept C502942594 @default.
• W2894776925 hasConcept C55493867 @default.
• W2894776925 hasConcept C86339819 @default.
• W2894776925 hasConcept C86803240 @default.
• W2894776925 hasConcept C8891405 @default.
• W2894776925 hasConcept C95444343 @default.

• next