FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894777761> ?p ?o ?g. }

• W2894777761 abstract "Background: Leishmaniasis is a protozoan disease ranging from simple to mucocutaneous, diffuse, and visceral lesions. Current chemical medicines, including Glucantime, have high toxicity, side effects, and drug resistance. Herbal medicines are unlimited sources for discovering new medications to treat infectious diseases. Objectives: This study aimed to examine the in vitro effect of hydroalcoholic extract of Artemisia absinthium on the growth of Leishmania major in peritoneal macrophages from BALB/c mice. Methods: In this experimental study, the hydroalcoholic extract of A. absinthium was prepared and dissolved in 2% dimethyl sulfoxide (DMSO). Leishmania major (MRHO/IR/75/ER) was cultured in RPMI1640 medium containing 15% fetal bovine serum (FBS). Peritoneal macrophages were extracted from BALB/c mice and were infected with promastigotes at a ratio of 1:10. The extract was added to Leishmania-infected macrophages and promastigotes at different concentrations. After 24, 48, and 72 hours, the effectiveness of A. absinthium on promastigotes was assessed using Trypan blue test and methyl thiazole tetrazolium (MTT) colorimetric assay, and the half maximal inhibitory concentration (IC50) of A. absinthium extract was obtained. Giemsa staining was used to evaluate the effect of A. absinthium extract on amastigotes. Also, inducible nitric oxide synthase (iNOs) level was measured from Leishmania-infected macrophages. The data were analyzed by ANOVA in SPSS software. Results: The hydroalcoholic extract of A. absinthium showed a significant anti-Leishmania activity against promastigotes and amastigotes at various concentrations after 48 and 72 hours. The IC50 values of the alcoholic extract of A. absinthium were obtained at 56 mg/mL and 51 mg/mL concentrations of promastigotes and amastigotes, respectively. The lowest levels of iNOs were seen at 100 and 50 mg/mL concentrations of A. absinthium in treated macrophages. The former was obtained at 60.8 and 58.8 ng/mL after 24 and 48 hours and the latter at 55.5 ng/mL and 50 mg/mL of A. absinthium, respectively, after 72 hours. Conclusions: Findings of the present study showed the anti-parasitic effects of A. absinthium on both promastigotes and amastigotes. Further studies are recommended to be conducted on animal models and the active ingredients of A. absinthium extract to accurately assess the effects of this extract on the growth of L. major." @default.
• W2894777761 created "2018-10-12" @default.
• W2894777761 creator A5025074627 @default.
• W2894777761 creator A5063101044 @default.
• W2894777761 creator A5079346649 @default.
• W2894777761 creator A5083351922 @default.
• W2894777761 date "2018-10-07" @default.
• W2894777761 modified "2023-09-26" @default.
• W2894777761 title "The In Vitro Effect of Hydroalcoholic Extract of Artemisia absinthium on the Growth of Leishmania major (MRHO/IR/75/ER) in Peritoneal Macrophages from BALB/c Mice" @default.
• W2894777761 cites W1109014584 @default.
• W2894777761 cites W1718940015 @default.
• W2894777761 cites W1765209286 @default.
• W2894777761 cites W1967775929 @default.
• W2894777761 cites W1969143455 @default.
• W2894777761 cites W1975916180 @default.
• W2894777761 cites W1977197891 @default.
• W2894777761 cites W1979715956 @default.
• W2894777761 cites W1982534773 @default.
• W2894777761 cites W1997080044 @default.
• W2894777761 cites W2003104596 @default.
• W2894777761 cites W2016017024 @default.
• W2894777761 cites W2030298145 @default.
• W2894777761 cites W2044107292 @default.
• W2894777761 cites W2047581463 @default.
• W2894777761 cites W2049411732 @default.
• W2894777761 cites W2066954635 @default.
• W2894777761 cites W2076357364 @default.
• W2894777761 cites W2107994133 @default.
• W2894777761 cites W2108184885 @default.
• W2894777761 cites W2127627541 @default.
• W2894777761 cites W2137979630 @default.
• W2894777761 cites W2154001185 @default.
• W2894777761 cites W2296520086 @default.
• W2894777761 cites W2624055932 @default.
• W2894777761 cites W2741508361 @default.
• W2894777761 cites W2797277084 @default.
• W2894777761 cites W2801891649 @default.
• W2894777761 doi "https://doi.org/10.5812/jjm.77302" @default.
• W2894777761 hasPublicationYear "2018" @default.
• W2894777761 type Work @default.
• W2894777761 sameAs 2894777761 @default.
• W2894777761 citedByCount "1" @default.
• W2894777761 countsByYear W28947777612021 @default.
• W2894777761 crossrefType "journal-article" @default.
• W2894777761 hasAuthorship W2894777761A5025074627 @default.
• W2894777761 hasAuthorship W2894777761A5063101044 @default.
• W2894777761 hasAuthorship W2894777761A5079346649 @default.
• W2894777761 hasAuthorship W2894777761A5083351922 @default.
• W2894777761 hasBestOaLocation W28947777611 @default.
• W2894777761 hasConcept C136764020 @default.
• W2894777761 hasConcept C142724271 @default.
• W2894777761 hasConcept C185592680 @default.
• W2894777761 hasConcept C19374876 @default.
• W2894777761 hasConcept C202751555 @default.
• W2894777761 hasConcept C203014093 @default.
• W2894777761 hasConcept C2776555147 @default.
• W2894777761 hasConcept C2777752497 @default.
• W2894777761 hasConcept C2780783641 @default.
• W2894777761 hasConcept C2781092759 @default.
• W2894777761 hasConcept C41008148 @default.
• W2894777761 hasConcept C55493867 @default.
• W2894777761 hasConcept C556039675 @default.
• W2894777761 hasConcept C71924100 @default.
• W2894777761 hasConcept C71928629 @default.
• W2894777761 hasConcept C86803240 @default.
• W2894777761 hasConcept C89423630 @default.
• W2894777761 hasConcept C98274493 @default.
• W2894777761 hasConcept C98319499 @default.
• W2894777761 hasConceptScore W2894777761C136764020 @default.
• W2894777761 hasConceptScore W2894777761C142724271 @default.
• W2894777761 hasConceptScore W2894777761C185592680 @default.
• W2894777761 hasConceptScore W2894777761C19374876 @default.
• W2894777761 hasConceptScore W2894777761C202751555 @default.
• W2894777761 hasConceptScore W2894777761C203014093 @default.
• W2894777761 hasConceptScore W2894777761C2776555147 @default.
• W2894777761 hasConceptScore W2894777761C2777752497 @default.
• W2894777761 hasConceptScore W2894777761C2780783641 @default.
• W2894777761 hasConceptScore W2894777761C2781092759 @default.
• W2894777761 hasConceptScore W2894777761C41008148 @default.
• W2894777761 hasConceptScore W2894777761C55493867 @default.
• W2894777761 hasConceptScore W2894777761C556039675 @default.
• W2894777761 hasConceptScore W2894777761C71924100 @default.
• W2894777761 hasConceptScore W2894777761C71928629 @default.
• W2894777761 hasConceptScore W2894777761C86803240 @default.
• W2894777761 hasConceptScore W2894777761C89423630 @default.
• W2894777761 hasConceptScore W2894777761C98274493 @default.
• W2894777761 hasConceptScore W2894777761C98319499 @default.
• W2894777761 hasIssue "In Press" @default.
• W2894777761 hasLocation W28947777611 @default.
• W2894777761 hasOpenAccess W2894777761 @default.
• W2894777761 hasPrimaryLocation W28947777611 @default.
• W2894777761 hasRelatedWork W2258495151 @default.
• W2894777761 hasRelatedWork W2300372494 @default.
• W2894777761 hasRelatedWork W2531662999 @default.
• W2894777761 hasRelatedWork W2717962958 @default.
• W2894777761 hasRelatedWork W2887694086 @default.
• W2894777761 hasRelatedWork W2996377958 @default.
• W2894777761 hasRelatedWork W3001031567 @default.
• W2894777761 hasRelatedWork W4226231319 @default.
• W2894777761 hasRelatedWork W4308544957 @default.

• next