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- W2894783902 abstract "Objective: Growing evidences suggest that genetic variation in inflammatory cytokines may play a key role in the development of postoperative atrial fibrillation (POAF). This study aimed to examine the association between three single-nucleotide polymorphisms in interleukin-6 receptor (IL-6R) gene Asp 358 A/C, IL-6 gene -174 G/C and -597 G/A and POAF following coronary artery bypass grafting (CABG). Methods: This prospective study enrolled 371 Chinese Han patients undergoing first time isolated CABG. The primary endpoint was the occurrence of POAF lasting ≥ 5mins. The patients were grouped as either POAF or non-POAF according to their ECGs, which were continuously monitored for the first 7 postoperative days. Genotypes for IL-6R gene Asp358 A/C, IL-6 gene -174 G/C and -597 G/A were determined. Multivariate logistic regression analysis was performed to identify independent risk factors for POAF. Results: Overall, 112 (30.2%) patients developed POAF. There was no significant difference in demographic and cl..." @default.
- W2894783902 created "2018-10-12" @default.
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- W2894783902 date "2015-11-10" @default.
- W2894783902 modified "2023-09-22" @default.
- W2894783902 title "Abstract 13440: The Asp358 A/C Polymorphism in Interleukin-6 Receptor Gene as a Novel Predictor of Atrial Fibrillation Following Coronary Artery Bypass Graft Surgery in Chinese Han Population" @default.
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