Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894786641> ?p ?o ?g. }
- W2894786641 endingPage "L93" @default.
- W2894786641 startingPage "L82" @default.
- W2894786641 abstract "Nonvisual opsin (OPN) receptors have recently been implicated in blue light-mediated photorelaxation of smooth muscle in various organs. Since photorelaxation has not yet been demonstrated in airway smooth muscle (ASM) or in human tissues, we questioned whether functional OPN receptors are expressed in mouse and human ASM. mRNA, encoding the OPN 3 receptor, was detected in both human and mouse ASM. To demonstrate the functionality of the OPN receptors, we performed wire myography of ex vivo ASM from mouse and human upper airways. Blue light-mediated relaxation of ACh-preconstricted airways was intensity and wavelength dependent (maximum relaxation at 430-nm blue light) and was inhibited by blockade of the large-conductance calcium-activated potassium channels with iberiotoxin. We further implicated OPN receptors as key mediators in functional photorelaxation by demonstrating increased relaxation in the presence of a G protein receptor kinase 2 inhibitor or an OPN chromophore (9- cis retinal). We corroborated these responses in peripheral airways of murine precision-cut lung slices. This is the first demonstration of photorelaxation in ASM via an OPN receptor-mediated pathway." @default.
- W2894786641 created "2018-10-12" @default.
- W2894786641 creator A5007096980 @default.
- W2894786641 creator A5012873342 @default.
- W2894786641 creator A5028812272 @default.
- W2894786641 creator A5044544424 @default.
- W2894786641 creator A5061995831 @default.
- W2894786641 creator A5064100811 @default.
- W2894786641 creator A5070962759 @default.
- W2894786641 creator A5091561517 @default.
- W2894786641 date "2019-01-01" @default.
- W2894786641 modified "2023-10-05" @default.
- W2894786641 title "Airway smooth muscle photorelaxation via opsin receptor activation" @default.
- W2894786641 cites W1482600529 @default.
- W2894786641 cites W1505860888 @default.
- W2894786641 cites W1533788848 @default.
- W2894786641 cites W1546408931 @default.
- W2894786641 cites W1559730701 @default.
- W2894786641 cites W1566146794 @default.
- W2894786641 cites W1604209299 @default.
- W2894786641 cites W179408000 @default.
- W2894786641 cites W1875615308 @default.
- W2894786641 cites W1973650169 @default.
- W2894786641 cites W1976219011 @default.
- W2894786641 cites W1977676788 @default.
- W2894786641 cites W1981905570 @default.
- W2894786641 cites W1986522060 @default.
- W2894786641 cites W1991234298 @default.
- W2894786641 cites W1996928274 @default.
- W2894786641 cites W2009843519 @default.
- W2894786641 cites W2010681228 @default.
- W2894786641 cites W2011916321 @default.
- W2894786641 cites W2019481749 @default.
- W2894786641 cites W2021332114 @default.
- W2894786641 cites W2023616028 @default.
- W2894786641 cites W2025138486 @default.
- W2894786641 cites W2030783952 @default.
- W2894786641 cites W2033603537 @default.
- W2894786641 cites W2035853180 @default.
- W2894786641 cites W2057588515 @default.
- W2894786641 cites W2060397148 @default.
- W2894786641 cites W2061658648 @default.
- W2894786641 cites W2064456564 @default.
- W2894786641 cites W2068089748 @default.
- W2894786641 cites W2075999393 @default.
- W2894786641 cites W2099699402 @default.
- W2894786641 cites W2104731624 @default.
- W2894786641 cites W2112200798 @default.
- W2894786641 cites W2115586501 @default.
- W2894786641 cites W2119398013 @default.
- W2894786641 cites W2133302347 @default.
- W2894786641 cites W2136879864 @default.
- W2894786641 cites W2155013903 @default.
- W2894786641 cites W2285089881 @default.
- W2894786641 cites W2554760137 @default.
- W2894786641 cites W2592561057 @default.
- W2894786641 cites W2605743572 @default.
- W2894786641 cites W2626167166 @default.
- W2894786641 cites W2748912324 @default.
- W2894786641 cites W2752918895 @default.
- W2894786641 cites W2756599047 @default.
- W2894786641 cites W2786709482 @default.
- W2894786641 cites W2788653860 @default.
- W2894786641 cites W2402252296 @default.
- W2894786641 doi "https://doi.org/10.1152/ajplung.00135.2018" @default.
- W2894786641 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6383505" @default.
- W2894786641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30284927" @default.
- W2894786641 hasPublicationYear "2019" @default.
- W2894786641 type Work @default.
- W2894786641 sameAs 2894786641 @default.
- W2894786641 citedByCount "22" @default.
- W2894786641 countsByYear W28947866412018 @default.
- W2894786641 countsByYear W28947866412019 @default.
- W2894786641 countsByYear W28947866412020 @default.
- W2894786641 countsByYear W28947866412021 @default.
- W2894786641 countsByYear W28947866412022 @default.
- W2894786641 countsByYear W28947866412023 @default.
- W2894786641 crossrefType "journal-article" @default.
- W2894786641 hasAuthorship W2894786641A5007096980 @default.
- W2894786641 hasAuthorship W2894786641A5012873342 @default.
- W2894786641 hasAuthorship W2894786641A5028812272 @default.
- W2894786641 hasAuthorship W2894786641A5044544424 @default.
- W2894786641 hasAuthorship W2894786641A5061995831 @default.
- W2894786641 hasAuthorship W2894786641A5064100811 @default.
- W2894786641 hasAuthorship W2894786641A5070962759 @default.
- W2894786641 hasAuthorship W2894786641A5091561517 @default.
- W2894786641 hasBestOaLocation W28947866411 @default.
- W2894786641 hasConcept C105702510 @default.
- W2894786641 hasConcept C12554922 @default.
- W2894786641 hasConcept C135285700 @default.
- W2894786641 hasConcept C170493617 @default.
- W2894786641 hasConcept C185592680 @default.
- W2894786641 hasConcept C55493867 @default.
- W2894786641 hasConcept C86803240 @default.
- W2894786641 hasConcept C95444343 @default.
- W2894786641 hasConceptScore W2894786641C105702510 @default.
- W2894786641 hasConceptScore W2894786641C12554922 @default.
- W2894786641 hasConceptScore W2894786641C135285700 @default.