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• W2894787593 abstract "Matrix metalloproteinases (Mmps) are pivotal extracellular proteinases participating in tissue remodeling. Three Mmps genes have been identified from the silkworm, Bombyx mori, and their expression levels and enzyme activity are consistent with progressive fat body cell dissociation during the early pupal stages. Using both loss-of-function and gain-of-function experiments, we have demonstrated that Mmps are functionally required for fat body cell dissociation and ovary development in female pupae. Moderate inhibition of Mmps activity via inhibitor treatments delayed fat body cell dissociation and ovary development, while severe inhibition blocked these developmental processes and eventually led to pupal lethality. Individual RNAi knockdown of each Mmp delayed fat body cell dissociation, with the strongest and weakest phenotypes occurring for Mmp3 and Mmp1, respectively. By contrast, overexpression of each Mmp promoted fat body cell dissociation and ovary development, with the strongest stimulatory effects for Mmp3 overexpression and the weakest effects for Mmp1 overexpression. This is the first time to show that Mmps induce fat body cell dissociation in Lepidoptera, and we also hypothesize that Mmps-induced fat body cell dissociation is required for ovary development in this insect species." @default.
• W2894787593 created "2018-10-12" @default.
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• W2894787593 date "2018-11-01" @default.
• W2894787593 modified "2023-10-14" @default.
• W2894787593 title "Matrix metalloproteinases promote fat body cell dissociation and ovary development in Bombyx mori" @default.
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• W2894787593 doi "https://doi.org/10.1016/j.jinsphys.2018.10.002" @default.
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