Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894787694> ?p ?o ?g. }
- W2894787694 endingPage "e12832" @default.
- W2894787694 startingPage "e12832" @default.
- W2894787694 abstract "Microglia, the resident immune cell of the brain, can be eliminated via pharmacological inhibition of the colony-stimulating factor 1 receptor (CSF1R). Withdrawal of CSF1R inhibition then stimulates microglial repopulation, effectively replacing the microglial compartment. In the aged brain, microglia take on a “primed” phenotype and studies indicate that this coincides with age-related cognitive decline. Here, we investigated the effects of replacing the aged microglial compartment with new microglia using CSF1R inhibitor-induced microglial repopulation. With 28 days of repopulation, replacement of resident microglia in aged mice (24 months) improved spatial memory and restored physical microglial tissue characteristics (cell densities and morphologies) to those found in young adult animals (4 months). However, inflammation-related gene expression was not broadly altered with repopulation nor the response to immune challenges. Instead, microglial repopulation resulted in a reversal of age-related changes in neuronal gene expression, including expression of genes associated with actin cytoskeleton remodeling and synaptogenesis. Age-related changes in hippocampal neuronal complexity were reversed with both microglial elimination and repopulation, while microglial elimination increased both neurogenesis and dendritic spine densities. These changes were accompanied by a full rescue of age-induced deficits in long-term potentiation with microglial repopulation. Thus, several key aspects of the aged brain can be reversed by acute noninvasive replacement of microglia." @default.
- W2894787694 created "2018-10-12" @default.
- W2894787694 creator A5021955687 @default.
- W2894787694 creator A5033672988 @default.
- W2894787694 creator A5034725945 @default.
- W2894787694 creator A5038511756 @default.
- W2894787694 creator A5047672739 @default.
- W2894787694 creator A5060158731 @default.
- W2894787694 creator A5062697236 @default.
- W2894787694 creator A5066725306 @default.
- W2894787694 creator A5077675303 @default.
- W2894787694 creator A5080683524 @default.
- W2894787694 creator A5085858912 @default.
- W2894787694 date "2018-10-02" @default.
- W2894787694 modified "2023-10-10" @default.
- W2894787694 title "Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice" @default.
- W2894787694 cites W1881610795 @default.
- W2894787694 cites W1920357305 @default.
- W2894787694 cites W1965482821 @default.
- W2894787694 cites W1974031039 @default.
- W2894787694 cites W1980789245 @default.
- W2894787694 cites W2002805214 @default.
- W2894787694 cites W2003674452 @default.
- W2894787694 cites W2009272942 @default.
- W2894787694 cites W2012517787 @default.
- W2894787694 cites W2015412022 @default.
- W2894787694 cites W2027467386 @default.
- W2894787694 cites W2037973854 @default.
- W2894787694 cites W2044219916 @default.
- W2894787694 cites W2047090417 @default.
- W2894787694 cites W2051504363 @default.
- W2894787694 cites W2060855101 @default.
- W2894787694 cites W2063724761 @default.
- W2894787694 cites W2078556521 @default.
- W2894787694 cites W2082414904 @default.
- W2894787694 cites W2093272100 @default.
- W2894787694 cites W2094660330 @default.
- W2894787694 cites W2097456438 @default.
- W2894787694 cites W2099005297 @default.
- W2894787694 cites W2101157207 @default.
- W2894787694 cites W2104431737 @default.
- W2894787694 cites W2113596790 @default.
- W2894787694 cites W2120911948 @default.
- W2894787694 cites W2121259136 @default.
- W2894787694 cites W2127381922 @default.
- W2894787694 cites W2146286641 @default.
- W2894787694 cites W2157137975 @default.
- W2894787694 cites W2163179762 @default.
- W2894787694 cites W2169700519 @default.
- W2894787694 cites W2261364877 @default.
- W2894787694 cites W2279776595 @default.
- W2894787694 cites W2280077905 @default.
- W2894787694 cites W2281702574 @default.
- W2894787694 cites W2407074051 @default.
- W2894787694 cites W2516246660 @default.
- W2894787694 cites W2568020671 @default.
- W2894787694 cites W2594403755 @default.
- W2894787694 cites W2725043130 @default.
- W2894787694 cites W2729351500 @default.
- W2894787694 cites W2738391310 @default.
- W2894787694 cites W2791700208 @default.
- W2894787694 cites W2797384836 @default.
- W2894787694 cites W982662479 @default.
- W2894787694 doi "https://doi.org/10.1111/acel.12832" @default.
- W2894787694 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6260908" @default.
- W2894787694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30276955" @default.
- W2894787694 hasPublicationYear "2018" @default.
- W2894787694 type Work @default.
- W2894787694 sameAs 2894787694 @default.
- W2894787694 citedByCount "209" @default.
- W2894787694 countsByYear W28947876942018 @default.
- W2894787694 countsByYear W28947876942019 @default.
- W2894787694 countsByYear W28947876942020 @default.
- W2894787694 countsByYear W28947876942021 @default.
- W2894787694 countsByYear W28947876942022 @default.
- W2894787694 countsByYear W28947876942023 @default.
- W2894787694 crossrefType "journal-article" @default.
- W2894787694 hasAuthorship W2894787694A5021955687 @default.
- W2894787694 hasAuthorship W2894787694A5033672988 @default.
- W2894787694 hasAuthorship W2894787694A5034725945 @default.
- W2894787694 hasAuthorship W2894787694A5038511756 @default.
- W2894787694 hasAuthorship W2894787694A5047672739 @default.
- W2894787694 hasAuthorship W2894787694A5060158731 @default.
- W2894787694 hasAuthorship W2894787694A5062697236 @default.
- W2894787694 hasAuthorship W2894787694A5066725306 @default.
- W2894787694 hasAuthorship W2894787694A5077675303 @default.
- W2894787694 hasAuthorship W2894787694A5080683524 @default.
- W2894787694 hasAuthorship W2894787694A5085858912 @default.
- W2894787694 hasBestOaLocation W28947876941 @default.
- W2894787694 hasConcept C109159458 @default.
- W2894787694 hasConcept C148762608 @default.
- W2894787694 hasConcept C169760540 @default.
- W2894787694 hasConcept C203014093 @default.
- W2894787694 hasConcept C2776914184 @default.
- W2894787694 hasConcept C2779830541 @default.
- W2894787694 hasConcept C2780918802 @default.
- W2894787694 hasConcept C28328180 @default.
- W2894787694 hasConcept C4746552 @default.