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• W2894788008 endingPage "436" @default.
• W2894788008 startingPage "419" @default.
• W2894788008 abstract "Abstract Pituitary adenomas (PA) and pheochromocytomas/paragangliomas (PHEO/PGL) are rare tumors. Although they may co-exist by coincidence, there is mounting evidence that genes predisposing in PHEO/PGL development, may play a role in pituitary tumorigenesis. In 2012, we described a GH-secreting PA caused by an SDHD mutation in a patient with familial PGLs and found loss of heterozygosity at the SDHD locus in the pituitary tumor, along with increased hypoxia-inducible factor 1α (HIF-1α) levels. Additional patients with PAs and SDHx defects have since been reported. Overall, prevalence of SDHx mutations in PA is very rare (0.3–1.8% in unselected cases) but we and others have identified several cases of PAs with PHEOs/PGLs, like our original report, a condition which we termed the 3 P association (3PAs). Interestingly, when 3PAs is found in the sporadic setting, no SDHx defects were identified, whereas in familial PGLs, SDHx mutations were identified in 62.5–75% of the reported cases. Hence, pituitary surveillance is recommended among patients with SDHx defects. It is possible that the SDHx germline mutation-negative 3PAs cases may be due to another gene, epigenetic changes, mutations in modifier genes, mosaicism, somatic mutations, pituitary hyperplasia due to ectopic hypothalamic hormone secretion or a coincidence. PA in 3PAs are mainly macroadenomas, more aggressive, more resistant to somatostatin analogues, and often require surgery. Using the Sdhb +/− mouse model, we showed that hyperplasia may be the first abnormality in tumorigenesis as initial response to pseudohypoxia. We also propose surveillance and follow-up approach of patients presenting with this association." @default.
• W2894788008 created "2018-10-12" @default.
• W2894788008 creator A5028135050 @default.
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• W2894788008 creator A5038356661 @default.
• W2894788008 creator A5076211111 @default.
• W2894788008 creator A5083166489 @default.
• W2894788008 date "2018-10-01" @default.
• W2894788008 modified "2023-09-27" @default.
• W2894788008 title "The 3PAs: An Update on the Association of Pheochromocytomas, Paragangliomas, and Pituitary Tumors" @default.
• W2894788008 cites W101319026 @default.
• W2894788008 cites W127450229 @default.
• W2894788008 cites W1457625536 @default.
• W2894788008 cites W1528834211 @default.
• W2894788008 cites W1580450956 @default.
• W2894788008 cites W1590672254 @default.
• W2894788008 cites W1849926932 @default.
• W2894788008 cites W1863395362 @default.
• W2894788008 cites W1863472108 @default.
• W2894788008 cites W1863863547 @default.
• W2894788008 cites W1965827991 @default.
• W2894788008 cites W1967033626 @default.
• W2894788008 cites W1972535033 @default.
• W2894788008 cites W1972661395 @default.
• W2894788008 cites W1973399318 @default.
• W2894788008 cites W1975535484 @default.
• W2894788008 cites W1976002503 @default.
• W2894788008 cites W1977015709 @default.
• W2894788008 cites W1987829547 @default.
• W2894788008 cites W1989146112 @default.
• W2894788008 cites W1995025616 @default.
• W2894788008 cites W1995530615 @default.
• W2894788008 cites W1996178263 @default.
• W2894788008 cites W1998947269 @default.
• W2894788008 cites W2001256348 @default.
• W2894788008 cites W2012276721 @default.
• W2894788008 cites W2016484623 @default.
• W2894788008 cites W2019055295 @default.
• W2894788008 cites W2025697637 @default.
• W2894788008 cites W2025719835 @default.
• W2894788008 cites W2034735961 @default.
• W2894788008 cites W2037745880 @default.
• W2894788008 cites W2041430419 @default.
• W2894788008 cites W2043232639 @default.
• W2894788008 cites W2050413914 @default.
• W2894788008 cites W2055050638 @default.
• W2894788008 cites W2057322654 @default.
• W2894788008 cites W2064782203 @default.
• W2894788008 cites W2071136688 @default.
• W2894788008 cites W2073170002 @default.
• W2894788008 cites W2074031392 @default.
• W2894788008 cites W2074878869 @default.
• W2894788008 cites W2075125843 @default.
• W2894788008 cites W2075492878 @default.
• W2894788008 cites W2078627327 @default.
• W2894788008 cites W2081060601 @default.
• W2894788008 cites W2083556825 @default.
• W2894788008 cites W2085763085 @default.
• W2894788008 cites W2088147435 @default.
• W2894788008 cites W2090290392 @default.
• W2894788008 cites W2090908599 @default.
• W2894788008 cites W2096791516 @default.
• W2894788008 cites W2099266559 @default.
• W2894788008 cites W2099838279 @default.
• W2894788008 cites W2100110884 @default.
• W2894788008 cites W2105266052 @default.
• W2894788008 cites W2105697797 @default.
• W2894788008 cites W2107855691 @default.
• W2894788008 cites W2110169976 @default.
• W2894788008 cites W2114786150 @default.
• W2894788008 cites W2115350520 @default.
• W2894788008 cites W2116263600 @default.
• W2894788008 cites W2117322796 @default.
• W2894788008 cites W2117792166 @default.
• W2894788008 cites W2118858851 @default.
• W2894788008 cites W2119169141 @default.
• W2894788008 cites W2119828866 @default.
• W2894788008 cites W2122372918 @default.
• W2894788008 cites W2125720260 @default.
• W2894788008 cites W2126511952 @default.
• W2894788008 cites W2127738340 @default.
• W2894788008 cites W2127952551 @default.
• W2894788008 cites W2129273005 @default.
• W2894788008 cites W2130550277 @default.
• W2894788008 cites W2130745966 @default.
• W2894788008 cites W2135003179 @default.
• W2894788008 cites W2135367483 @default.
• W2894788008 cites W2136589587 @default.
• W2894788008 cites W2139228552 @default.
• W2894788008 cites W2142238703 @default.
• W2894788008 cites W2142282076 @default.
• W2894788008 cites W2145361345 @default.
• W2894788008 cites W2152430532 @default.
• W2894788008 cites W2154727709 @default.
• W2894788008 cites W2155465275 @default.
• W2894788008 cites W2156515257 @default.
• W2894788008 cites W2157407784 @default.
• W2894788008 cites W2162037934 @default.

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