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- W2894795483 abstract "We report the design, synthesis and biological evaluation of 17 novel 8-aryl-2-morpholino-3,4-dihydroquinazoline derivatives based on the standard model of DNA-PK and PI3K inhibitors. Novel compounds are sub-divided into two series where the second series of five derivatives was designed to have a better solubility profile over the first one. A combination of in vitro and in silico techniques suggested a plausible synergistic effect with doxorubicin of the most potent compound 14d on cell proliferation via DNA-PK and poly(ADP-ribose) polymerase-1 (PARP-1) inhibition, while alone having a negligible effect on cell proliferation." @default.
- W2894795483 created "2018-10-12" @default.
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- W2894795483 date "2019-02-01" @default.
- W2894795483 modified "2023-09-24" @default.
- W2894795483 title "Novel quinazolin-4-one derivatives as potentiating agents of doxorubicin cytotoxicity" @default.
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- W2894795483 doi "https://doi.org/10.1016/j.bioorg.2018.10.001" @default.
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