Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894795605> ?p ?o ?g. }
- W2894795605 abstract "Abstract Many recent efforts to analyze cancer genomes involve aggregation of mutations within reference maps of molecular pathways and protein networks. Here, we find these pathway studies are impeded by molecular interactions that are functionally irrelevant to cancer or the patient’s tumor type, as these interactions diminish the contrast of driver pathways relative to individual frequently mutated genes. This problem can be addressed by creating stringent tumor-specific networks of biophysical protein interactions, identified by signatures of epistatic selection during tumor evolution. Using such an evolutionarily selected pathway (ESP) map, we analyze the major cancer genome atlases to derive a hierarchical classification of tumor subtypes linked to characteristic mutated pathways. These pathways are clinically prognostic and predictive, including the TP53-AXIN-ARHGEF17 combination in liver and CYLC2-STK11-STK11IP in lung cancer, which we validate in independent cohorts. This ESP framework substantially improves the definition of cancer pathways and subtypes from tumor genome data." @default.
- W2894795605 created "2018-10-12" @default.
- W2894795605 creator A5007315039 @default.
- W2894795605 creator A5026087488 @default.
- W2894795605 creator A5032624863 @default.
- W2894795605 creator A5033111996 @default.
- W2894795605 creator A5061177999 @default.
- W2894795605 creator A5074269040 @default.
- W2894795605 creator A5089373684 @default.
- W2894795605 date "2018-10-08" @default.
- W2894795605 modified "2023-10-02" @default.
- W2894795605 title "Typing tumors using pathways selected by somatic evolution" @default.
- W2894795605 cites W1908864745 @default.
- W2894795605 cites W1940319397 @default.
- W2894795605 cites W1967220865 @default.
- W2894795605 cites W1977186059 @default.
- W2894795605 cites W1981409633 @default.
- W2894795605 cites W1982467516 @default.
- W2894795605 cites W1982564236 @default.
- W2894795605 cites W1987219048 @default.
- W2894795605 cites W2009720434 @default.
- W2894795605 cites W2033591223 @default.
- W2894795605 cites W2038122249 @default.
- W2894795605 cites W2038910496 @default.
- W2894795605 cites W2044702943 @default.
- W2894795605 cites W2050086663 @default.
- W2894795605 cites W2057619131 @default.
- W2894795605 cites W2061061337 @default.
- W2894795605 cites W2061136308 @default.
- W2894795605 cites W2080383499 @default.
- W2894795605 cites W2080878119 @default.
- W2894795605 cites W2088891952 @default.
- W2894795605 cites W2096173332 @default.
- W2894795605 cites W2096283457 @default.
- W2894795605 cites W2098749998 @default.
- W2894795605 cites W2100714130 @default.
- W2894795605 cites W2104261859 @default.
- W2894795605 cites W2105280376 @default.
- W2894795605 cites W2106157865 @default.
- W2894795605 cites W2108068107 @default.
- W2894795605 cites W2109317370 @default.
- W2894795605 cites W2109816625 @default.
- W2894795605 cites W2117235735 @default.
- W2894795605 cites W2118037512 @default.
- W2894795605 cites W2121906867 @default.
- W2894795605 cites W2123696077 @default.
- W2894795605 cites W2124637492 @default.
- W2894795605 cites W2126172213 @default.
- W2894795605 cites W2129973040 @default.
- W2894795605 cites W2132623845 @default.
- W2894795605 cites W2132630169 @default.
- W2894795605 cites W2134964552 @default.
- W2894795605 cites W2138669911 @default.
- W2894795605 cites W2141744105 @default.
- W2894795605 cites W2144940507 @default.
- W2894795605 cites W2164298117 @default.
- W2894795605 cites W2168264491 @default.
- W2894795605 cites W2237475663 @default.
- W2894795605 cites W2262414037 @default.
- W2894795605 cites W2295275561 @default.
- W2894795605 cites W2303043072 @default.
- W2894795605 cites W2461427403 @default.
- W2894795605 cites W2494960642 @default.
- W2894795605 cites W2556519015 @default.
- W2894795605 cites W2558534012 @default.
- W2894795605 cites W2560367415 @default.
- W2894795605 cites W2585261240 @default.
- W2894795605 cites W2588463727 @default.
- W2894795605 cites W2601016637 @default.
- W2894795605 cites W2603587832 @default.
- W2894795605 cites W2612467560 @default.
- W2894795605 cites W2613362156 @default.
- W2894795605 cites W2624021832 @default.
- W2894795605 cites W2735272571 @default.
- W2894795605 cites W2739511077 @default.
- W2894795605 cites W2741508285 @default.
- W2894795605 cites W2772435237 @default.
- W2894795605 cites W2808223587 @default.
- W2894795605 cites W4230962320 @default.
- W2894795605 cites W4312512934 @default.
- W2894795605 cites W571060166 @default.
- W2894795605 cites W953912505 @default.
- W2894795605 doi "https://doi.org/10.1038/s41467-018-06464-y" @default.
- W2894795605 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6175900" @default.
- W2894795605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30297789" @default.
- W2894795605 hasPublicationYear "2018" @default.
- W2894795605 type Work @default.
- W2894795605 sameAs 2894795605 @default.
- W2894795605 citedByCount "18" @default.
- W2894795605 countsByYear W28947956052019 @default.
- W2894795605 countsByYear W28947956052020 @default.
- W2894795605 countsByYear W28947956052021 @default.
- W2894795605 countsByYear W28947956052022 @default.
- W2894795605 countsByYear W28947956052023 @default.
- W2894795605 crossrefType "journal-article" @default.
- W2894795605 hasAuthorship W2894795605A5007315039 @default.
- W2894795605 hasAuthorship W2894795605A5026087488 @default.
- W2894795605 hasAuthorship W2894795605A5032624863 @default.
- W2894795605 hasAuthorship W2894795605A5033111996 @default.
- W2894795605 hasAuthorship W2894795605A5061177999 @default.