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- W2894795816 abstract "A new Zn(II) metal-organic framework (MOFs), [Zn(BTC)(HME)]·(DMAc)(H2O) (1, H3BTC =1,3,5-benzenetricarboxylic acid, HME = protonated melamine, DMAc = N,N-dimethylacetamide), has been synthesized under solvothermal conditions. In the structure of 1, the four-coordinate Zn(II) ions are connected by BTC3− ligands into a 3-D framework with (3)-connected utg-type topology. This MOF shows permanent porosity after lattice solvent removal with a calculated pore size distribution around 0.72 nm. With abundant N-donor sites and suitable pore size, the desolvated 1 (1a) was used as a drug carrier for the loading of anticancer drug 5-fluorouracil (5-Fu) molecules. Moderate 5-Fu loading capacity and long drug release time were observed for 1a. The computational simulation results reveal that strong H-bond interactions between the 5-Fu molecules and the nitrogen sites allow slow release of the drug 1a. In addition, the in vitro cytotoxicity of 1 and 5-Fu loaded 1a were also evaluated using MTT assays against human oral squamous cell carcinoma (SCC-251 and HSC-4)." @default.
- W2894795816 created "2018-10-12" @default.
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- W2894795816 date "2018-11-02" @default.
- W2894795816 modified "2023-09-26" @default.
- W2894795816 title "A mixed-ligand approach for building a N-rich porous metal-organic framework for drug release and anticancer activity against oral squamous cell carcinoma" @default.
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- W2894795816 doi "https://doi.org/10.1080/00958972.2018.1528499" @default.
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