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- W2894797382 endingPage "a033506" @default.
- W2894797382 startingPage "a033506" @default.
- W2894797382 abstract "The TMC1 channel was identified as a protein essential for hearing in mouse and human, and recognized as one of a family of eight such proteins in mammals. The TMC family is part of a superfamily of seven branches, which includes the TMEM16s. Vertebrate hair cells express both TMC1 and TMC2. They are located at the tips of stereocilia and are required for hair cell mechanotransduction. TMC1 assembles as a dimer and its similarity to the TMEM16s has enabled a predicted tertiary structure with an ion conduction pore in each subunit of the dimer. Cysteine mutagenesis of the pore supports the role of TMC1 and TMC2 as the core channel proteins of a larger mechanotransduction complex that includes PCDH15 and LHFPL5, and perhaps TMIE, CIB2 and others." @default.
- W2894797382 created "2018-10-12" @default.
- W2894797382 creator A5013341831 @default.
- W2894797382 creator A5022666092 @default.
- W2894797382 creator A5081441104 @default.
- W2894797382 date "2018-10-05" @default.
- W2894797382 modified "2023-10-18" @default.
- W2894797382 title "Function and Dysfunction of TMC Channels in Inner Ear Hair Cells" @default.
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- W2894797382 doi "https://doi.org/10.1101/cshperspect.a033506" @default.
- W2894797382 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6450785" @default.
- W2894797382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30291150" @default.
- W2894797382 hasPublicationYear "2018" @default.
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