FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894798257> ?p ?o ?g. }

• W2894798257 abstract "Lung microinvasive adenocarcinoma (MIA) is a newly-defined subtype of early stage non-small cell lung cancer (NSCLC). However, its epidermal growth factor receptor (EGFR) mutation status and clinical significance remain unclear. The present study aimed to determine EGFR mutation characteristics and identify their significance in patients with resected lung MIA. The present study also analyzed clinicopathological differences between EGFR molecular subgroups defined as 19Del and L858R. The present study examined EGFR mutations in 79 consecutive lung MIA resection specimens and compared the differences in clinicopathological features between the EGFR wild-type and mutation groups, as well as between the 19Del and L858R subgroups. EGFR mutations were detected in 60 (75.95%) tumors. The most common mutations were 19Del (28 cases; 35.44%) and L858R (30 cases; 37.97%). Two patients harbored rare mutations and one of them had a concomitant double mutation. EGFR mutations were significantly associated with microinvasion component, thyroid transcription factor 1 (TTF-1) expression, intratumoral fibrosis and inflammatory cell infiltration. Subgroup evaluation indicated that there was a significant association between 19Del and tumor size, maximum diameter of microinvasion, presence of intratumoral fibrosis and inflammatory cell infiltration. Similar associations were observed for the L858R subgroup, and L858R was associated with TTF-1 expression. In particular, 19Del occurred more frequently in MIA with a smaller size, with a smaller microinvasive area, without TTF-1 expression, and lacking intratumoral fibrosis and inflammatory cell infiltration. By contrast, L858R was detected more frequently in MIA with entirely different tumor features. In conclusion, the results of the present study indicated that surgically resected MIA cases harboring different EGFR gene statuses exhibit distinct clinicopathological features. Significant differences in pathological features associated with the tumor microenvironment were identified in MIA with 19Del or L858R mutations. Therefore, the present study proposed that MIA should be classified into molecular subgroups based on EGFR mutation subtypes. The molecular sub-classification should be taken into account for prognostic evaluation and clinical management of MIA." @default.
• W2894798257 created "2018-10-12" @default.
• W2894798257 creator A5005110304 @default.
• W2894798257 creator A5039889042 @default.
• W2894798257 creator A5047113750 @default.
• W2894798257 creator A5048123067 @default.
• W2894798257 creator A5066452142 @default.
• W2894798257 date "2018-10-02" @default.
• W2894798257 modified "2023-09-27" @default.
• W2894798257 title "Significance of the epidermal growth factor receptor mutation status and differences among molecular subgroups in surgically resected lung microinvasive adenocarcinoma" @default.
• W2894798257 cites W1780888641 @default.
• W2894798257 cites W1874454018 @default.
• W2894798257 cites W1931438814 @default.
• W2894798257 cites W1953677527 @default.
• W2894798257 cites W1968707775 @default.
• W2894798257 cites W1972387812 @default.
• W2894798257 cites W1974935634 @default.
• W2894798257 cites W1976697496 @default.
• W2894798257 cites W1977332018 @default.
• W2894798257 cites W1978843400 @default.
• W2894798257 cites W1978928671 @default.
• W2894798257 cites W1980532363 @default.
• W2894798257 cites W1985495260 @default.
• W2894798257 cites W1988195303 @default.
• W2894798257 cites W1998322093 @default.
• W2894798257 cites W2002157461 @default.
• W2894798257 cites W2021481801 @default.
• W2894798257 cites W2032511716 @default.
• W2894798257 cites W2043081988 @default.
• W2894798257 cites W2045799337 @default.
• W2894798257 cites W2049674541 @default.
• W2894798257 cites W2053050910 @default.
• W2894798257 cites W2056180028 @default.
• W2894798257 cites W2075691289 @default.
• W2894798257 cites W2077813812 @default.
• W2894798257 cites W2084645564 @default.
• W2894798257 cites W2085957460 @default.
• W2894798257 cites W2087766713 @default.
• W2894798257 cites W2095618958 @default.
• W2894798257 cites W2096198395 @default.
• W2894798257 cites W2111662961 @default.
• W2894798257 cites W2118019849 @default.
• W2894798257 cites W2127585436 @default.
• W2894798257 cites W2128800782 @default.
• W2894798257 cites W2129360604 @default.
• W2894798257 cites W2132870547 @default.
• W2894798257 cites W2133149289 @default.
• W2894798257 cites W2134989772 @default.
• W2894798257 cites W2136989592 @default.
• W2894798257 cites W2143859186 @default.
• W2894798257 cites W2144853738 @default.
• W2894798257 cites W2147703884 @default.
• W2894798257 cites W2147952742 @default.
• W2894798257 cites W2149733252 @default.
• W2894798257 cites W2150658403 @default.
• W2894798257 cites W2151439214 @default.
• W2894798257 cites W2154662831 @default.
• W2894798257 cites W2157824687 @default.
• W2894798257 cites W2160982674 @default.
• W2894798257 cites W2166836693 @default.
• W2894798257 cites W2171139285 @default.
• W2894798257 cites W2187090435 @default.
• W2894798257 cites W2251438188 @default.
• W2894798257 cites W2256341952 @default.
• W2894798257 cites W2531562320 @default.
• W2894798257 cites W2570618306 @default.
• W2894798257 cites W2598204500 @default.
• W2894798257 cites W2599161770 @default.
• W2894798257 cites W2747107616 @default.
• W2894798257 cites W2767140127 @default.
• W2894798257 cites W2770635318 @default.
• W2894798257 cites W2796055736 @default.
• W2894798257 doi "https://doi.org/10.3892/ol.2018.9539" @default.
• W2894798257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6256736" @default.
• W2894798257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30546439" @default.
• W2894798257 hasPublicationYear "2018" @default.
• W2894798257 type Work @default.
• W2894798257 sameAs 2894798257 @default.
• W2894798257 citedByCount "0" @default.
• W2894798257 crossrefType "journal-article" @default.
• W2894798257 hasAuthorship W2894798257A5005110304 @default.
• W2894798257 hasAuthorship W2894798257A5039889042 @default.
• W2894798257 hasAuthorship W2894798257A5047113750 @default.
• W2894798257 hasAuthorship W2894798257A5048123067 @default.
• W2894798257 hasAuthorship W2894798257A5066452142 @default.
• W2894798257 hasBestOaLocation W28947982571 @default.
• W2894798257 hasConcept C121608353 @default.
• W2894798257 hasConcept C126322002 @default.
• W2894798257 hasConcept C142724271 @default.
• W2894798257 hasConcept C143998085 @default.
• W2894798257 hasConcept C2776256026 @default.
• W2894798257 hasConcept C2777714996 @default.
• W2894798257 hasConcept C2779438470 @default.
• W2894798257 hasConcept C2779563347 @default.
• W2894798257 hasConcept C2781182431 @default.
• W2894798257 hasConcept C2909723608 @default.
• W2894798257 hasConcept C29537977 @default.
• W2894798257 hasConcept C502942594 @default.
• W2894798257 hasConcept C63363279 @default.
• W2894798257 hasConcept C67082663 @default.

• next