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• W2894800513 abstract "Auranofin is an FDA approved drug for the treatment of rheumatoid arthritis. In a repurposing effort, it has been extensively tested as an anticancer drug throughout the past decade. Regardless of the potent cytotoxicity observed for auranofin, there are many reports on lack of selectivity. Inspired by the structure of auranofin, and aiming to improve the cytotoxic selectivity, we decided to evaluate the cytotoxicity of the Au(I)-phosphine series of compounds. The correlation between chemical structure and reactivity of the compounds with model biomolecules such as N-Ac-Cys and ZnFs was deeply discussed in Chaps. 1 and 3 . Furthermore, the very same aspects that govern reactivity in the molecular level, such as the basicity and bulkiness of the phosphine ligand, σ-donating properties and lability of the co-ligands L (L = Cl or 4-dimethylaminopyridine, dmap) and overall charge of the compounds (neutral vs. cationic) are also expected to play a role in cytotoxic response, establishing an interesting set of parameters that can be correlated." @default.
• W2894800513 created "2018-10-12" @default.
• W2894800513 creator A5045828089 @default.
• W2894800513 creator A5081840551 @default.
• W2894800513 date "2018-01-01" @default.
• W2894800513 modified "2023-10-02" @default.
• W2894800513 title "Probing Cells: Evaluating Cytotoxicity" @default.
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• W2894800513 doi "https://doi.org/10.1007/978-3-030-00853-6_4" @default.
• W2894800513 hasPublicationYear "2018" @default.
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