FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894809968> ?p ?o ?g. }

• W2894809968 endingPage "202" @default.
• W2894809968 startingPage "173" @default.
• W2894809968 abstract "Mechanical and solvent stresses in wet granulation can induce physical changes in the drug substance or excipients undergoing granulation. These physical changes can be in the form of solid state transformation such as polymorphic change, salt disproportionation, or hydrate formation. Micromeritic (particle structure/property changes) also can take place during wet granulation. Partial transformation of anhydrous lactose to lactose monohydrate in high shear wet granulation is an example of solid state transformation. Despite form conversion of anhydrous lactose to lactose monohydrate during wet granulation, it retains its inherent particle morphology, surface area, and porosity. The higher compactibility of anhydrous lactose was maintained after wet granulation, indicating that particle structure, and not crystal structure, is the factor governing performance of lactose in compaction. The decrease in MCC particle porosity by wet granulation is an example of micromeritic changes in wet granulation. The decrease in MCC primary particle porosity resulted in the decrease in MCC compactibility even without significant particle size growth. Aggregation of MCC particles into large dense granules when the binder is included in the formulation resulted in further decrease in compactibility. Milling counteracts the effect of wet granulation on MCC compactibility as particle surface area and porosity are increased by milling." @default.
• W2894809968 created "2018-10-12" @default.
• W2894809968 creator A5012000730 @default.
• W2894809968 date "2019-01-01" @default.
• W2894809968 modified "2023-10-14" @default.
• W2894809968 title "Material Physical Modifications Induced by Wet Granulation" @default.
• W2894809968 cites W1505631108 @default.
• W2894809968 cites W1569320270 @default.
• W2894809968 cites W1978656413 @default.
• W2894809968 cites W1979535436 @default.
• W2894809968 cites W1984081365 @default.
• W2894809968 cites W1987420005 @default.
• W2894809968 cites W1988065217 @default.
• W2894809968 cites W1988971929 @default.
• W2894809968 cites W1989202574 @default.
• W2894809968 cites W1992758740 @default.
• W2894809968 cites W2002880551 @default.
• W2894809968 cites W2003193650 @default.
• W2894809968 cites W2003633805 @default.
• W2894809968 cites W2008724908 @default.
• W2894809968 cites W2009612376 @default.
• W2894809968 cites W2013547871 @default.
• W2894809968 cites W2027941548 @default.
• W2894809968 cites W2029845157 @default.
• W2894809968 cites W2041199994 @default.
• W2894809968 cites W2044152737 @default.
• W2894809968 cites W2045069402 @default.
• W2894809968 cites W2046720339 @default.
• W2894809968 cites W2046797645 @default.
• W2894809968 cites W2059996147 @default.
• W2894809968 cites W2063960950 @default.
• W2894809968 cites W2064683108 @default.
• W2894809968 cites W2068219232 @default.
• W2894809968 cites W2071853811 @default.
• W2894809968 cites W2075556981 @default.
• W2894809968 cites W2083167562 @default.
• W2894809968 cites W2085481328 @default.
• W2894809968 cites W2087234082 @default.
• W2894809968 cites W2095214450 @default.
• W2894809968 cites W2095237804 @default.
• W2894809968 cites W2099645928 @default.
• W2894809968 cites W2164558532 @default.
• W2894809968 cites W2164722103 @default.
• W2894809968 cites W2171010789 @default.
• W2894809968 cites W2335248207 @default.
• W2894809968 cites W2566763285 @default.
• W2894809968 cites W2604278565 @default.
• W2894809968 cites W72627025 @default.
• W2894809968 cites W2113112726 @default.
• W2894809968 doi "https://doi.org/10.1016/b978-0-12-810460-6.00014-2" @default.
• W2894809968 hasPublicationYear "2019" @default.
• W2894809968 type Work @default.
• W2894809968 sameAs 2894809968 @default.
• W2894809968 citedByCount "3" @default.
• W2894809968 countsByYear W28948099682020 @default.
• W2894809968 countsByYear W28948099682023 @default.
• W2894809968 crossrefType "book-chapter" @default.
• W2894809968 hasAuthorship W2894809968A5012000730 @default.
• W2894809968 hasConcept C111368507 @default.
• W2894809968 hasConcept C127313418 @default.
• W2894809968 hasConcept C127413603 @default.
• W2894809968 hasConcept C159985019 @default.
• W2894809968 hasConcept C178790620 @default.
• W2894809968 hasConcept C185592680 @default.
• W2894809968 hasConcept C187530423 @default.
• W2894809968 hasConcept C187714232 @default.
• W2894809968 hasConcept C192562407 @default.
• W2894809968 hasConcept C196715460 @default.
• W2894809968 hasConcept C199289684 @default.
• W2894809968 hasConcept C2778517922 @default.
• W2894809968 hasConcept C2778724459 @default.
• W2894809968 hasConcept C42360764 @default.
• W2894809968 hasConcept C6648577 @default.
• W2894809968 hasConcept C88463166 @default.
• W2894809968 hasConceptScore W2894809968C111368507 @default.
• W2894809968 hasConceptScore W2894809968C127313418 @default.
• W2894809968 hasConceptScore W2894809968C127413603 @default.
• W2894809968 hasConceptScore W2894809968C159985019 @default.
• W2894809968 hasConceptScore W2894809968C178790620 @default.
• W2894809968 hasConceptScore W2894809968C185592680 @default.
• W2894809968 hasConceptScore W2894809968C187530423 @default.
• W2894809968 hasConceptScore W2894809968C187714232 @default.
• W2894809968 hasConceptScore W2894809968C192562407 @default.
• W2894809968 hasConceptScore W2894809968C196715460 @default.
• W2894809968 hasConceptScore W2894809968C199289684 @default.
• W2894809968 hasConceptScore W2894809968C2778517922 @default.
• W2894809968 hasConceptScore W2894809968C2778724459 @default.
• W2894809968 hasConceptScore W2894809968C42360764 @default.
• W2894809968 hasConceptScore W2894809968C6648577 @default.
• W2894809968 hasConceptScore W2894809968C88463166 @default.
• W2894809968 hasLocation W28948099681 @default.
• W2894809968 hasOpenAccess W2894809968 @default.
• W2894809968 hasPrimaryLocation W28948099681 @default.
• W2894809968 hasRelatedWork W2012445395 @default.
• W2894809968 hasRelatedWork W2045069402 @default.
• W2894809968 hasRelatedWork W2075580692 @default.
• W2894809968 hasRelatedWork W2093275523 @default.
• W2894809968 hasRelatedWork W2112712346 @default.

• next