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- W2894810732 abstract "A one-pot strategy combining sortase A mediated on-resin peptide cleavage and in situ cyclization was developed for the synthesis of cyclic peptides. This strategy was applied to synthesize head-to-tail cyclic antibacterial bovine lactoferricin peptide LFcinB20–35 in a yield of 67%. The one-pot strategy was compatible with an oxidative folding reaction, and complex cyclotides containing one or two disulfide bonds, such as sunflower trypsin inhibitors-1 and α-conotoxin MII, were successfully synthesized in one pot in a yield of 77% and 61%, respectively." @default.
- W2894810732 created "2018-10-12" @default.
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- W2894810732 date "2018-10-02" @default.
- W2894810732 modified "2023-10-15" @default.
- W2894810732 title "Enzymatic On-Resin Peptide Cleavage and in Situ Cyclization One-Pot Strategy for the Synthesis of Cyclopeptide and Cyclotide" @default.
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- W2894810732 doi "https://doi.org/10.1021/acs.joc.8b02032" @default.
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