FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894811403> ?p ?o ?g. }

• W2894811403 endingPage "510A" @default.
• W2894811403 startingPage "510A" @default.
• W2894811403 abstract "SESSION TITLE: Disorders of the Pleura SESSION TYPE: Original Investigation Posters PRESENTED ON: 10/10/2018 01:00 pm - 02:00 pm PURPOSE: The goal of this study was to evaluate how the administration of tissue plasminogen activator (tPA) and DNase therapy for complicated parapneumonic effusions and empyema affects patient outcomes in an inner city community hospital. METHODS: This retrospective analysis was performed at an inner city hospital located in Raleigh, North Carolina. A list of all patients treated with tPA and DNase between the dates 7/1/2015 and 12/31/2017 was generated and screened. Data was collected through review of past medical records, including demographics, past medical history, and details about their hospital course. RESULTS: A total of 38 patients were found to have been treated with concurrent tPA and DNase for complicated parapneumonic effusion or empyema. Fourteen were female (36.8%). The mean age was 61.4 years. There were 31 Caucasians, 6 African-Americans, and 1 Asian-American. Eight (21%) had a history of malignancy and 12 (32%) had a history of previous pulmonary disease. Of the effusions, 25 (65.8%) were located on the right side. A total of 29 (76.3%) effusions were loculated. The mean pleural pH was 6.84. There were 26 (68.4%) treated with chest tubes sized at 20 French or less. Pleural fluid cultures returned positive for 21 (55.3%), with the most common causative agents being MRSA (10.5%) and alpha-hemolytic Streptococci (10.5%). Twenty (52.6%) patients received the full 6 doses of combined concurrent tPA/DNase. Of the 18 (47.4%) who did not, 11 did not require the full 6 doses for effusion resolution, and 7 had to discontinue therapy due to tube blockage or pain. Only 7 (18.4%) patients had complications related to tPA/DNase administration, most commonly pain. Nineteen (50%) patients had complete radiological clearance of effusion, with 13 (34.2%) having partial clearance, and 6 (15.8%) having no change or worsening of their effusion. Eight (21.1%) patients needed further surgical management of their effusion. CONCLUSIONS: Although the use of concurrent tPA and DNase has been relatively well studied with encouraging results, there has been little research elucidating the effects of dosing on therapeutic efficacy. Moreover, all the prior studies have occurred in university hospital and not in community hospitals. Currently, most protocols are twice daily for three days, totaling six doses. The optimal duration and dose however is unknown. The results from our study suggest some patients do not require the full six doses for improvement of effusion, or that some patients may require more than the typical six doses. As such, further research is required evaluate the optimal dose and duration to improve drainage to further optimize patient outcomes. CLINICAL IMPLICATIONS: The current most common dosing pattern for combined tPA and DNase therapy of twice daily for three days may not be optimal for all patients. Dosing regimen should be individualized depending on clinical response. DISCLOSURES: No relevant relationships by Vikas Pathak, source=Web Response No relevant relationships by Christine Zhou, source=Web Response" @default.
• W2894811403 created "2018-10-12" @default.
• W2894811403 creator A5007795522 @default.
• W2894811403 creator A5085395887 @default.
• W2894811403 date "2018-10-01" @default.
• W2894811403 modified "2023-10-18" @default.
• W2894811403 title "EFFECTS OF CONCURRENT DOSING ON THE EFFICACY OF TISSUE PLASMINOGEN ACTIVATOR AND DNASE IN THE TREATMENT OF PLEURAL INFECTION" @default.
• W2894811403 doi "https://doi.org/10.1016/j.chest.2018.08.464" @default.
• W2894811403 hasPublicationYear "2018" @default.
• W2894811403 type Work @default.
• W2894811403 sameAs 2894811403 @default.
• W2894811403 citedByCount "1" @default.
• W2894811403 crossrefType "journal-article" @default.
• W2894811403 hasAuthorship W2894811403A5007795522 @default.
• W2894811403 hasAuthorship W2894811403A5085395887 @default.
• W2894811403 hasConcept C126322002 @default.
• W2894811403 hasConcept C141071460 @default.
• W2894811403 hasConcept C195910791 @default.
• W2894811403 hasConcept C206179267 @default.
• W2894811403 hasConcept C2776572282 @default.
• W2894811403 hasConcept C2776979038 @default.
• W2894811403 hasConcept C2777000465 @default.
• W2894811403 hasConcept C2777799383 @default.
• W2894811403 hasConcept C2779399171 @default.
• W2894811403 hasConcept C2779634585 @default.
• W2894811403 hasConcept C2779679481 @default.
• W2894811403 hasConcept C2993292583 @default.
• W2894811403 hasConcept C71924100 @default.
• W2894811403 hasConcept C90924648 @default.
• W2894811403 hasConceptScore W2894811403C126322002 @default.
• W2894811403 hasConceptScore W2894811403C141071460 @default.
• W2894811403 hasConceptScore W2894811403C195910791 @default.
• W2894811403 hasConceptScore W2894811403C206179267 @default.
• W2894811403 hasConceptScore W2894811403C2776572282 @default.
• W2894811403 hasConceptScore W2894811403C2776979038 @default.
• W2894811403 hasConceptScore W2894811403C2777000465 @default.
• W2894811403 hasConceptScore W2894811403C2777799383 @default.
• W2894811403 hasConceptScore W2894811403C2779399171 @default.
• W2894811403 hasConceptScore W2894811403C2779634585 @default.
• W2894811403 hasConceptScore W2894811403C2779679481 @default.
• W2894811403 hasConceptScore W2894811403C2993292583 @default.
• W2894811403 hasConceptScore W2894811403C71924100 @default.
• W2894811403 hasConceptScore W2894811403C90924648 @default.
• W2894811403 hasIssue "4" @default.
• W2894811403 hasLocation W28948114031 @default.
• W2894811403 hasOpenAccess W2894811403 @default.
• W2894811403 hasPrimaryLocation W28948114031 @default.
• W2894811403 hasRelatedWork W1767625075 @default.
• W2894811403 hasRelatedWork W1800520966 @default.
• W2894811403 hasRelatedWork W1809460789 @default.
• W2894811403 hasRelatedWork W1999439147 @default.
• W2894811403 hasRelatedWork W2029961202 @default.
• W2894811403 hasRelatedWork W2084074893 @default.
• W2894811403 hasRelatedWork W2894811403 @default.
• W2894811403 hasRelatedWork W4224236637 @default.
• W2894811403 hasRelatedWork W4283275715 @default.
• W2894811403 hasRelatedWork W2186528691 @default.
• W2894811403 hasVolume "154" @default.
• W2894811403 isParatext "false" @default.
• W2894811403 isRetracted "false" @default.
• W2894811403 magId "2894811403" @default.
• W2894811403 workType "article" @default.