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- W2894821853 abstract "Chromatin acetylation, a critical regulator of synaptic plasticity and memory processes, is thought to be altered in neurodegenerative diseases. Here, we demonstrate that spatial memory and plasticity (LTD, dendritic spine formation) deficits can be restored in a mouse model of tauopathy following treatment with CSP-TTK21, a small-molecule activator of CBP/p300 histone acetyltransferases (HAT). At the transcriptional level, CSP-TTK21 re-established half of the hippocampal transcriptome in learning mice, likely through increased expression of neuronal activity genes and memory enhancers. At the epigenomic level, the hippocampus of tauopathic mice showed a significant decrease in H2B but not H3K27 acetylation levels, both marks co-localizing at TSS and CBP enhancers. Importantly, CSP-TTK21 treatment increased H2B acetylation levels at decreased peaks, CBP enhancers, and TSS, including genes associated with plasticity and neuronal functions, overall providing a 95% rescue of the H2B acetylome in tauopathic mice. This study is the first to provide in vivo proof-of-concept evidence that CBP/p300 HAT activation efficiently reverses epigenetic, transcriptional, synaptic plasticity, and behavioral deficits associated with Alzheimer's disease lesions in mice." @default.
- W2894821853 created "2018-10-12" @default.
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- W2894821853 date "2018-10-01" @default.
- W2894821853 modified "2023-10-12" @default.
- W2894821853 title "Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator" @default.
- W2894821853 cites W1520100911 @default.
- W2894821853 cites W1775494655 @default.
- W2894821853 cites W1824457652 @default.
- W2894821853 cites W1963551704 @default.
- W2894821853 cites W1972364189 @default.
- W2894821853 cites W1972587767 @default.
- W2894821853 cites W1976464296 @default.
- W2894821853 cites W1977419289 @default.
- W2894821853 cites W1979594866 @default.
- W2894821853 cites W1983756628 @default.
- W2894821853 cites W1985951212 @default.
- W2894821853 cites W1992797403 @default.
- W2894821853 cites W1998707569 @default.
- W2894821853 cites W2012140908 @default.
- W2894821853 cites W2013152269 @default.
- W2894821853 cites W2014677321 @default.
- W2894821853 cites W2014787267 @default.
- W2894821853 cites W2014950836 @default.
- W2894821853 cites W2021880506 @default.
- W2894821853 cites W2029002395 @default.
- W2894821853 cites W2037412924 @default.
- W2894821853 cites W2042966900 @default.
- W2894821853 cites W2046459630 @default.
- W2894821853 cites W2048364484 @default.
- W2894821853 cites W2064874105 @default.
- W2894821853 cites W2073789350 @default.
- W2894821853 cites W2077905824 @default.
- W2894821853 cites W2080228104 @default.
- W2894821853 cites W2080456178 @default.
- W2894821853 cites W2086376086 @default.
- W2894821853 cites W2094182857 @default.
- W2894821853 cites W2096149923 @default.
- W2894821853 cites W2096460391 @default.
- W2894821853 cites W2096963202 @default.
- W2894821853 cites W2101611410 @default.
- W2894821853 cites W2102573876 @default.
- W2894821853 cites W2102619694 @default.
- W2894821853 cites W2114138025 @default.
- W2894821853 cites W2119137351 @default.
- W2894821853 cites W2121053876 @default.
- W2894821853 cites W2124643275 @default.
- W2894821853 cites W2124985265 @default.
- W2894821853 cites W2125309982 @default.
- W2894821853 cites W2125644182 @default.
- W2894821853 cites W2125805216 @default.
- W2894821853 cites W2127081697 @default.
- W2894821853 cites W2128811302 @default.
- W2894821853 cites W2135397980 @default.
- W2894821853 cites W2137720344 @default.
- W2894821853 cites W2140729960 @default.
- W2894821853 cites W2142388403 @default.
- W2894821853 cites W2143461767 @default.
- W2894821853 cites W2145552255 @default.
- W2894821853 cites W2145976523 @default.
- W2894821853 cites W2146648681 @default.
- W2894821853 cites W2149102165 @default.
- W2894821853 cites W2152239989 @default.
- W2894821853 cites W2155048015 @default.
- W2894821853 cites W2157316790 @default.
- W2894821853 cites W2158074192 @default.
- W2894821853 cites W2158217645 @default.
- W2894821853 cites W2170725855 @default.
- W2894821853 cites W2177873964 @default.
- W2894821853 cites W2179438025 @default.
- W2894821853 cites W2199911847 @default.
- W2894821853 cites W2287111360 @default.
- W2894821853 cites W2331819283 @default.
- W2894821853 cites W2332027634 @default.
- W2894821853 cites W2507461348 @default.
- W2894821853 cites W2514975062 @default.
- W2894821853 cites W2548767848 @default.
- W2894821853 cites W2549799731 @default.
- W2894821853 cites W2556389549 @default.
- W2894821853 cites W2564861566 @default.