Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894822059> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2894822059 endingPage "364" @default.
- W2894822059 startingPage "364" @default.
- W2894822059 abstract "Generic drugs are approved when they are shown to be bio-equivalent in their pharmacokinetic profiles. Whether the pharmacological effect of the generic formulation is similar to the brand is not always easy to see if there is no observable physiological effect of the drug. ADP multiplate test is used to measure platelet reactivity in blood samples from patients who are taking P2Y12 inhibitors. The study aims was to compare platelet reactivity using multiplate ADP test while on brand clopidogrel (Plavix) and generic clopidogrel (Pedovex). Patients gave informed consent to participate in this prospective open label cross over study. Patients took brand clopidogrel (Plavix) for one month followed by ADP testing then switched to (Pedovex) for one month with repeat APD testing or vice versa. All patients were stable on chronic therapy. Those who had a stent less than one month were not included in the study. All physicians taking care of patients were blinded to the ADP results till the study was completed. 89 patients gave informed consent. Complete ADP data was available for 73 patients. No patient had any stent thrombosis event during the course of the study and none had any bleeding episode. Both formulations were equally well tolerated. Concordant response of ADP was observed in 89% of the patients and was discordant in 11%. ADP response was lower in 4 patients while on brand clopidogrel and was lower in 4 patients while on generic clopidogrel. Generic clopidogrel (Pedovex) was similar to brand clopidogrel (Plavix) in its effect on ADP Multiplate test on Chronic Therapy." @default.
- W2894822059 created "2018-10-12" @default.
- W2894822059 creator A5002286452 @default.
- W2894822059 creator A5011145727 @default.
- W2894822059 creator A5013529954 @default.
- W2894822059 creator A5017788259 @default.
- W2894822059 creator A5024991274 @default.
- W2894822059 creator A5037738651 @default.
- W2894822059 creator A5039262846 @default.
- W2894822059 creator A5041446311 @default.
- W2894822059 creator A5041943737 @default.
- W2894822059 creator A5048581137 @default.
- W2894822059 creator A5081981515 @default.
- W2894822059 date "2018-10-01" @default.
- W2894822059 modified "2023-09-25" @default.
- W2894822059 title "Platelet reactivity on brand and generic clopidogrel chronic therapy" @default.
- W2894822059 doi "https://doi.org/10.1016/j.jsha.2018.05.022" @default.
- W2894822059 hasPublicationYear "2018" @default.
- W2894822059 type Work @default.
- W2894822059 sameAs 2894822059 @default.
- W2894822059 citedByCount "0" @default.
- W2894822059 crossrefType "journal-article" @default.
- W2894822059 hasAuthorship W2894822059A5002286452 @default.
- W2894822059 hasAuthorship W2894822059A5011145727 @default.
- W2894822059 hasAuthorship W2894822059A5013529954 @default.
- W2894822059 hasAuthorship W2894822059A5017788259 @default.
- W2894822059 hasAuthorship W2894822059A5024991274 @default.
- W2894822059 hasAuthorship W2894822059A5037738651 @default.
- W2894822059 hasAuthorship W2894822059A5039262846 @default.
- W2894822059 hasAuthorship W2894822059A5041446311 @default.
- W2894822059 hasAuthorship W2894822059A5041943737 @default.
- W2894822059 hasAuthorship W2894822059A5048581137 @default.
- W2894822059 hasAuthorship W2894822059A5081981515 @default.
- W2894822059 hasBestOaLocation W28948220591 @default.
- W2894822059 hasConcept C126322002 @default.
- W2894822059 hasConcept C2777628954 @default.
- W2894822059 hasConcept C2777849778 @default.
- W2894822059 hasConcept C2909112448 @default.
- W2894822059 hasConcept C42219234 @default.
- W2894822059 hasConcept C49059817 @default.
- W2894822059 hasConcept C71924100 @default.
- W2894822059 hasConcept C89560881 @default.
- W2894822059 hasConcept C98274493 @default.
- W2894822059 hasConceptScore W2894822059C126322002 @default.
- W2894822059 hasConceptScore W2894822059C2777628954 @default.
- W2894822059 hasConceptScore W2894822059C2777849778 @default.
- W2894822059 hasConceptScore W2894822059C2909112448 @default.
- W2894822059 hasConceptScore W2894822059C42219234 @default.
- W2894822059 hasConceptScore W2894822059C49059817 @default.
- W2894822059 hasConceptScore W2894822059C71924100 @default.
- W2894822059 hasConceptScore W2894822059C89560881 @default.
- W2894822059 hasConceptScore W2894822059C98274493 @default.
- W2894822059 hasIssue "4" @default.
- W2894822059 hasLocation W28948220591 @default.
- W2894822059 hasLocation W28948220592 @default.
- W2894822059 hasOpenAccess W2894822059 @default.
- W2894822059 hasPrimaryLocation W28948220591 @default.
- W2894822059 hasRelatedWork W1468775069 @default.
- W2894822059 hasRelatedWork W1493950155 @default.
- W2894822059 hasRelatedWork W1984368932 @default.
- W2894822059 hasRelatedWork W2035054244 @default.
- W2894822059 hasRelatedWork W2074491742 @default.
- W2894822059 hasRelatedWork W2111109999 @default.
- W2894822059 hasRelatedWork W2116611908 @default.
- W2894822059 hasRelatedWork W2189601282 @default.
- W2894822059 hasRelatedWork W2235698526 @default.
- W2894822059 hasRelatedWork W2574602345 @default.
- W2894822059 hasVolume "30" @default.
- W2894822059 isParatext "false" @default.
- W2894822059 isRetracted "false" @default.
- W2894822059 magId "2894822059" @default.
- W2894822059 workType "article" @default.