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- W2894822955 abstract "Abstract Replication protein A (RPA) coordinates important DNA metabolic events by stabilizing single-strand DNA (ssDNA) intermediates, activating the DNA damage response, and handing off ssDNA to appropriate downstream players. Six DNA binding domains (DBDs) in RPA promote high affinity binding to ssDNA, but also allow RPA displacement by lower affinity proteins. We have made fluorescent versions of RPA and visualized the conformational dynamics of individual DBDs in the context of the full-length protein. We show that both DBD-A and DBD-D rapidly bind to and dissociate from ssDNA, while RPA as a whole remains bound to ssDNA. The recombination mediator protein Rad52 selectively modulates the dynamics of DBD-D. This demonstrates how RPA interacting proteins, with lower ssDNA binding affinity, can access the occluded ssDNA and remodel individual DBDs to replace RPA. One Sentence Summary The choreography of binding and rearrangement of the individual domains of RPA during homologous recombination is revealed." @default.
- W2894822955 created "2018-10-12" @default.
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- W2894822955 date "2018-10-04" @default.
- W2894822955 modified "2023-10-14" @default.
- W2894822955 title "Dynamics and Selective Remodeling of the DNA Binding Domains of RPA" @default.
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- W2894822955 doi "https://doi.org/10.1101/435636" @default.
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