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- W2894828304 abstract "The post-synthetic O-acetylation of the essential component of bacterial cell walls, peptidoglycan (PG), is performed by many pathogenic bacteria to help them evade the lytic action of innate immunity responses. Occurring at the C-6 hydroxyl of N-acetylmuramoyl residues, this modification to the glycan backbone of PG sterically blocks the activity of lysozymes. As such, the enzyme responsible for this modification in Gram-positive bacteria is recognized as a virulence factor. With Gram-negative bacteria, the O-acetylation of PG provides a means of control of their autolysins at the substrate level. In this review, we discuss the pathways for PG O-acetylation and de-O-acetylation and the structure and function relationship of the O-acetyltransferases and O-acetylesterases that catalyze these reactions. The current understanding of their mechanisms of action is presented and the prospects of targeting these systems for the development of novel therapeutics are explored." @default.
- W2894828304 created "2018-10-12" @default.
- W2894828304 creator A5005909858 @default.
- W2894828304 creator A5018686723 @default.
- W2894828304 creator A5063240146 @default.
- W2894828304 creator A5071345338 @default.
- W2894828304 date "2018-10-01" @default.
- W2894828304 modified "2023-10-13" @default.
- W2894828304 title "Mechanistic Pathways for Peptidoglycan O-Acetylation and De-O-Acetylation" @default.
- W2894828304 cites W121315196 @default.
- W2894828304 cites W1478816797 @default.
- W2894828304 cites W1492250056 @default.
- W2894828304 cites W1501122529 @default.
- W2894828304 cites W1594682929 @default.
- W2894828304 cites W1601925021 @default.
- W2894828304 cites W1783885505 @default.
- W2894828304 cites W1824325504 @default.
- W2894828304 cites W1892418848 @default.
- W2894828304 cites W1949690724 @default.
- W2894828304 cites W1954531392 @default.
- W2894828304 cites W1959649751 @default.
- W2894828304 cites W1963683707 @default.
- W2894828304 cites W1964499067 @default.
- W2894828304 cites W1966934427 @default.
- W2894828304 cites W1967075678 @default.
- W2894828304 cites W1967663562 @default.
- W2894828304 cites W1979640591 @default.
- W2894828304 cites W1983344500 @default.
- W2894828304 cites W1985297470 @default.
- W2894828304 cites W1987006179 @default.
- W2894828304 cites W1987165856 @default.
- W2894828304 cites W1988775133 @default.
- W2894828304 cites W1989171083 @default.
- W2894828304 cites W1990043420 @default.
- W2894828304 cites W1990891051 @default.
- W2894828304 cites W1994226427 @default.
- W2894828304 cites W1998544844 @default.
- W2894828304 cites W2001652739 @default.
- W2894828304 cites W2007163142 @default.
- W2894828304 cites W2007791539 @default.
- W2894828304 cites W2012200956 @default.
- W2894828304 cites W2013682050 @default.
- W2894828304 cites W2015064264 @default.
- W2894828304 cites W2020583398 @default.
- W2894828304 cites W2022732592 @default.
- W2894828304 cites W2029373994 @default.
- W2894828304 cites W2030106086 @default.
- W2894828304 cites W2031360652 @default.
- W2894828304 cites W2032819924 @default.
- W2894828304 cites W2035158221 @default.
- W2894828304 cites W2035460901 @default.
- W2894828304 cites W2038057037 @default.
- W2894828304 cites W2038278235 @default.
- W2894828304 cites W2038444095 @default.
- W2894828304 cites W2044562813 @default.
- W2894828304 cites W2050584128 @default.
- W2894828304 cites W2052140557 @default.
- W2894828304 cites W2054738943 @default.
- W2894828304 cites W2056405753 @default.
- W2894828304 cites W2057239744 @default.
- W2894828304 cites W2060476013 @default.
- W2894828304 cites W2060881171 @default.
- W2894828304 cites W2061953031 @default.
- W2894828304 cites W2063219607 @default.
- W2894828304 cites W2064358027 @default.
- W2894828304 cites W2071057327 @default.
- W2894828304 cites W2077358324 @default.
- W2894828304 cites W2079740756 @default.
- W2894828304 cites W2083371863 @default.
- W2894828304 cites W2085136523 @default.
- W2894828304 cites W2089068194 @default.
- W2894828304 cites W2092788509 @default.
- W2894828304 cites W2095402347 @default.
- W2894828304 cites W2101182659 @default.
- W2894828304 cites W2103072608 @default.
- W2894828304 cites W2103301321 @default.
- W2894828304 cites W2109793735 @default.
- W2894828304 cites W2112580008 @default.
- W2894828304 cites W2115069651 @default.
- W2894828304 cites W2116859600 @default.
- W2894828304 cites W2125258338 @default.
- W2894828304 cites W2128701738 @default.
- W2894828304 cites W2131547551 @default.
- W2894828304 cites W2131966979 @default.
- W2894828304 cites W2134114753 @default.
- W2894828304 cites W2134246747 @default.
- W2894828304 cites W2135301585 @default.
- W2894828304 cites W2138003010 @default.
- W2894828304 cites W2141099568 @default.
- W2894828304 cites W2141413828 @default.
- W2894828304 cites W2145894970 @default.
- W2894828304 cites W2146333624 @default.
- W2894828304 cites W2149941565 @default.
- W2894828304 cites W2151020563 @default.
- W2894828304 cites W2152432564 @default.
- W2894828304 cites W2157372528 @default.
- W2894828304 cites W2157435671 @default.
- W2894828304 cites W2158304257 @default.
- W2894828304 cites W2158691001 @default.
- W2894828304 cites W2159240817 @default.