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• W2894829544 abstract "Kawasaki disease (KD) is an acute febrile illness predominantly affecting children less than 5 years of age and characterized by systemic inflammation in all medium-sized arteries. Adult-onset KD (AKD) is rare with only 105 case reports published. Recently, the efficacy of infliximab (IFX) for patients with refractory KD has been demonstrated.A previously healthy 24-year-old man was admitted because of a persistent fever, and elevated serum level of AST, ALT, LDH, and CRP.The patients met the diagnostic criteria for KD based on the findings of persistent fever, polymorphous exanthema, unilateral cervical lymphadenopathy, non-purulent palpebral conjunctivitis and membranous desquamation. Echocardiogram revealed the dilatation at the proximal sites of the right coronary artery (7.9 mm) and left anterior descending artery (5 mm). The patient was treated with high-dose intravenous immunoglobulin (1 g/kg/day for 2 days) and ASA (100 mg daily). However, his fever and arthralgia persisted.He was administered single 5 mg/kg doses of IFX.He became afebrile the next day and his arthralgia improved.We report the first case of administration of IFX in a patient with AKD refractory to intravenous immunoglobulin (IVIG), and successful reduction of systemic inflammation. However, the effectiveness of IFX in the regression of coronary artery aneurysm remains to be determined." @default.
• W2894829544 created "2018-10-12" @default.
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• W2894829544 date "2018-10-01" @default.
• W2894829544 modified "2023-10-14" @default.
• W2894829544 title "Infliximab as an alternative therapy for refractory adult onset Kawasaki disease" @default.
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• W2894829544 doi "https://doi.org/10.1097/md.0000000000012720" @default.
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