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• W2894831689 abstract "A series of 8-hydroxy quinolines were identified as potent inhibitors of catechol O-methyltransferase (COMT) with selectivity for the membrane-bound form of the enzyme. Small substituents at the 7-position of the quinoline were found to increase metabolic stability without sacrificing potency. Compounds with good pharmacokinetics and brain penetration were identified and demonstrated in vivo modulation of dopamine metabolites in the brain. An X-ray cocrystal structure of compound 21 in the S-COMT active site shows chelation of the active site magnesium similar to catechol-based inhibitors. These compounds should prove useful for treatment of many neurological and psychiatric conditions associated with compromised cortical dopamine signaling." @default.
• W2894831689 created "2018-10-12" @default.
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• W2894831689 date "2018-10-01" @default.
• W2894831689 modified "2023-10-06" @default.
• W2894831689 title "Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol <i>O</i>-Methyltransferase" @default.
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• W2894831689 doi "https://doi.org/10.1021/acs.jmedchem.8b01126" @default.
• W2894831689 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6398604" @default.
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