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- W2894832787 abstract "Solitary malignant melanoma (MM) metastasis to the pancreas are rare and occur in approximately 1% of patients with metastatic MM. Historically, most patients are considered unresectable. However, resection of isolated metastasis could extend disease free survival benefit, particularly in the absence of effective systemic therapies. We present a case of pancreatic resection for isolated MM metastasis along with a review of the English published literature. Patients with extra-pancreatic disease and patients who did not undergo surgery were excluded. We report a case of a 46-year-old woman, with a right arm MM excised nine years ago, who presented with an isolated tail of the pancreas mass on routine follow-up. Laparoscopic distal pancreatectomy and splenectomy was preformed and revealed a 28mm metastatic MM, with negative resection margins. The patient is asymptomatic with no recurrence 10 months after the resection. No adjuvant treatment was given. The literature review revealed 3 case series and 21 case reports with a total of 37 patients. The follow-up ranged from 1-264 months with a 5 year survival of 37,5% reported. It appears that in carefully selected patients surgery may offer an overall survival benefit. Resection of isolated pancreatic metastases should be considered as it may provide a significant survival benefit for a disease with high mortality and lack of effective systemic therapies. Multidisciplinary decision and treatment in high volume centres is mandatory." @default.
- W2894832787 created "2018-10-12" @default.
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- W2894832787 date "2018-09-01" @default.
- W2894832787 modified "2023-09-26" @default.
- W2894832787 title "Surgical treatment of solitary malignant melanoma metastasis to the pancreas – case report and literature review" @default.
- W2894832787 doi "https://doi.org/10.1016/j.hpb.2018.06.2078" @default.
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