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- W2894832836 abstract "The administration of 5-aminolevulinic acid (ALA) to generate enhanced intracellular levels of endogenous porphyrins is currently one of the most important approaches for photodynamic therapy (PDT) and photodiagnosis (PDD). Despite the great promise of ALA-based PDT, the physicochemical behaviour and chemical reactivity of ALA are problematic, and a variety of chemical approaches have been brought to bear to improve cellular delivery, enhance porphyrin production, and generate ALA prodrugs that have appropriate stability for convenient clinical use, as well as selectivity for cancerous tissues. While there has been considerable success, there are still a number of challenges to be addressed and opportunities to be exploited through application of chemical insight in this area." @default.
- W2894832836 created "2018-10-12" @default.
- W2894832836 creator A5040651463 @default.
- W2894832836 creator A5047307860 @default.
- W2894832836 date "2018-11-01" @default.
- W2894832836 modified "2023-10-13" @default.
- W2894832836 title "Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis" @default.
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- W2894832836 doi "https://doi.org/10.1039/c8pp00362a" @default.
- W2894832836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30328459" @default.
- W2894832836 hasPublicationYear "2018" @default.