Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894832928> ?p ?o ?g. }
- W2894832928 abstract "JEV, a main cause of severe viral encephalitis in humans, has a complex ecology composed of a mosquito-waterbird cycle and a cycle involving pigs, which amplifies virus transmission to mosquitoes, leading to increased human cases. JEV can be transmitted between pigs by contact in the absence of arthropod vectors. Moreover, virus or viral RNA is found in oronasal secretions and the nasal epithelium. Using nasal mucosa tissue explants and three-dimensional porcine nasal epithelial cells cultures and macrophages as ex vivo and in vitro models, we determined that the nasal epithelium could be a route of entry as well as exit for the virus. Infection of nasal epithelial cells resulted in apical and basolateral virus shedding and release of monocyte recruiting chemokines and therefore infection and replication in macrophages, which is favored by epithelial-cell-derived cytokines. The results are relevant to understand the mechanism of non-vector-borne direct transmission of JEV." @default.
- W2894832928 created "2018-10-12" @default.
- W2894832928 creator A5001782263 @default.
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- W2894832928 date "2018-12-15" @default.
- W2894832928 modified "2023-10-14" @default.
- W2894832928 title "Targeting of the Nasal Mucosa by Japanese Encephalitis Virus for Non-Vector-Borne Transmission" @default.
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- W2894832928 doi "https://doi.org/10.1128/jvi.01091-18" @default.
- W2894832928 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6258954" @default.
- W2894832928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30282716" @default.
- W2894832928 hasPublicationYear "2018" @default.
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