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- W2894838646 abstract "Given the increasing trend in bacterial antibiotic resistance, research on antimicrobial peptides and their mechanisms of action has become of huge relevance in the last years. Several studies have investigated the effects of a large variety of antimicrobial peptides directly on bacteria or on model lipid bilayers. In the case of model lipid bilayers, different systems are typically exploited; however, different results could be obtained due to the specific properties of the used system. Supported Lipid Bilayers and Giant Unilamellar Vesicles are among the most popular model systems. Here we used Atomic Force Microscopy and fluorescence microscopy to study the interaction of the antimicrobial peptide Magainin H2, an analog of Magainin 2 with increased hydrophobicity, on Supported Lipid Bilayers. We found that, for this kind of model bilayer, due to its strong interaction with the support, the lateral expansion of the membrane induced by the interaction with the peptides is initially inhibited and subsequently proceeds creating new bilayer regions with many defects. This scenario gives rise in Supported Lipid Bilayers to effects like initial increase of lateral pressure, formation of lipid tubes to release this increase, or development of bilayer regions with lower lipid density. Our results highlight that care should be given to the selected model system when studying and comparing the interaction of peptides with other lipid bilayer model systems." @default.
- W2894838646 created "2018-10-12" @default.
- W2894838646 creator A5007113313 @default.
- W2894838646 creator A5010727575 @default.
- W2894838646 creator A5057349143 @default.
- W2894838646 date "2018-12-01" @default.
- W2894838646 modified "2023-09-26" @default.
- W2894838646 title "Effects of the peptide Magainin H2 on Supported Lipid Bilayers studied by different biophysical techniques" @default.
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- W2894838646 doi "https://doi.org/10.1016/j.bbamem.2018.10.003" @default.
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