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- W2894839713 abstract "Introduction: The aim of our study was to compare the outcomes of pure laparoscopic (LLR) and open (OLR) liver resections in patients with hepatocellular carcinoma. Method: We have searched EMBASE, Medline and The Cochrane Library databases in order to find all studies reporting morbidity in patients undergoing LLR vs. OLR. The statistical analysis was performed using RevMan 5.3. Quality of studies was assessed by the Newcastle-Ottawa and Jadad scales. The study followed the PRISMA guidelines. Results: From 3,852 articles revealed in an initial search, 43 (N=5,100 patients) matched the inclusion criteria. All of the studies except one were non-randomized trials. There was a significant trend of submitting patients with smaller lesions to LLR (MD -0.26 95%CI: -0.42 to -0.10) Pooled risk ratios analysis showed a statistically significant reduction in overall morbidity in LLR group (15.59% vs. 29.88%, RR=0.53, 95%CI: 0.47-0.60). There were no differences between groups in terms of mortality (1.58% vs. 2.96%, p=0.05) and both 3- and 5-year overall and disease-free survival. Conclusion: The meta-analysis showed that LLR is beneficial in terms of safety over OLR. Having said that, these results are based on non-randomized trials which may be biased due to differences in tumor size between groups. Thus, we are calling for randomization in upcoming studies." @default.
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- W2894839713 date "2018-09-01" @default.
- W2894839713 modified "2023-10-16" @default.
- W2894839713 title "A Plea for randomized trials: systematic review and meta-analysis on postoperative outcomes in pure laparoscopic and open liver surgery for hepatocellular carcinoma" @default.
- W2894839713 doi "https://doi.org/10.1016/j.hpb.2018.06.2689" @default.
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