FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894841092> ?p ?o ?g. }

• W2894841092 endingPage "43" @default.
• W2894841092 startingPage "31" @default.
• W2894841092 abstract "In bilaterians, animal/vegetal axial (A/V) patterning is a fundamental early developmental event for establishment of animal/vegetal polarity and following specification of the germ layers (ectoderm, mesoderm, endoderm), of which the evolutionary origin is enigmatic. Understanding A/V axial patterning in a basal animal from each phylum would help to reconstruct the ancestral state of germ layer specification in bilaterians and thus, the evolution of mesoderm, the third intermediate cell layer. Herein, data show that the canonical Wnt/β-catenin (cWnt) and Notch signaling pathways control mesoderm specification from the early endomesoderm in the basal chordate amphioxus. Amphioxus belongs to the deuterostome, one of the main superphyla in Bilateria. In the present study, genes (tcf, dsh, axin, gsk3β) encoding cWnt components were expressed in the endomesoderm during the gastrula stages. Excess cWnt signaling by BIO, a GSK3 inhibitor, expanded the expression domains of outer endomesodermal genes that include future mesodermal ones and suppressed inner endomesodermal and ectodermal genes. Interfering Notch signaling by DAPT, a γ-secretase inhibitor, resulted in decreased expression of ectodermal and endomesodermal markers. These results suggest that cWnt and Notch have important roles in mesoderm specification in amphioxus embryos. The evolution of the mesoderm is also discussed." @default.
• W2894841092 created "2018-10-12" @default.
• W2894841092 creator A5060285281 @default.
• W2894841092 date "2018-10-04" @default.
• W2894841092 modified "2023-09-24" @default.
• W2894841092 title "Canonical Wnt/β-catenin and Notch signaling regulate animal/vegetal axial patterning in the cephalochordate amphioxus" @default.
• W2894841092 cites W1565208357 @default.
• W2894841092 cites W1595442736 @default.
• W2894841092 cites W1841157386 @default.
• W2894841092 cites W1901203685 @default.
• W2894841092 cites W1938764043 @default.
• W2894841092 cites W1968064237 @default.
• W2894841092 cites W1972004518 @default.
• W2894841092 cites W1975001515 @default.
• W2894841092 cites W1977673144 @default.
• W2894841092 cites W1977865827 @default.
• W2894841092 cites W1977918032 @default.
• W2894841092 cites W1978732075 @default.
• W2894841092 cites W1985785239 @default.
• W2894841092 cites W1989289226 @default.
• W2894841092 cites W1989889624 @default.
• W2894841092 cites W1990773683 @default.
• W2894841092 cites W1995207946 @default.
• W2894841092 cites W1997675270 @default.
• W2894841092 cites W2003264562 @default.
• W2894841092 cites W2008115426 @default.
• W2894841092 cites W2009785574 @default.
• W2894841092 cites W2010740217 @default.
• W2894841092 cites W2012948809 @default.
• W2894841092 cites W2014104129 @default.
• W2894841092 cites W2033797505 @default.
• W2894841092 cites W2056968521 @default.
• W2894841092 cites W2057256047 @default.
• W2894841092 cites W2058370341 @default.
• W2894841092 cites W2065273292 @default.
• W2894841092 cites W2071651257 @default.
• W2894841092 cites W2081080947 @default.
• W2894841092 cites W2100331382 @default.
• W2894841092 cites W2124805860 @default.
• W2894841092 cites W2128024200 @default.
• W2894841092 cites W2131871062 @default.
• W2894841092 cites W2134088890 @default.
• W2894841092 cites W2134175977 @default.
• W2894841092 cites W2142698995 @default.
• W2894841092 cites W2144859227 @default.
• W2894841092 cites W2145394911 @default.
• W2894841092 cites W2161838556 @default.
• W2894841092 cites W2180144291 @default.
• W2894841092 cites W2189331713 @default.
• W2894841092 cites W2207117262 @default.
• W2894841092 cites W2405216112 @default.
• W2894841092 cites W2595470124 @default.
• W2894841092 cites W2809024494 @default.
• W2894841092 doi "https://doi.org/10.1111/ede.12273" @default.
• W2894841092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30288919" @default.
• W2894841092 hasPublicationYear "2018" @default.
• W2894841092 type Work @default.
• W2894841092 sameAs 2894841092 @default.
• W2894841092 citedByCount "10" @default.
• W2894841092 countsByYear W28948410922020 @default.
• W2894841092 countsByYear W28948410922021 @default.
• W2894841092 countsByYear W28948410922022 @default.
• W2894841092 countsByYear W28948410922023 @default.
• W2894841092 crossrefType "journal-article" @default.
• W2894841092 hasAuthorship W2894841092A5060285281 @default.
• W2894841092 hasConcept C104317684 @default.
• W2894841092 hasConcept C105702510 @default.
• W2894841092 hasConcept C107459253 @default.
• W2894841092 hasConcept C129536746 @default.
• W2894841092 hasConcept C137620995 @default.
• W2894841092 hasConcept C145103041 @default.
• W2894841092 hasConcept C161879069 @default.
• W2894841092 hasConcept C18155467 @default.
• W2894841092 hasConcept C193252679 @default.
• W2894841092 hasConcept C196843134 @default.
• W2894841092 hasConcept C2777164004 @default.
• W2894841092 hasConcept C2777738586 @default.
• W2894841092 hasConcept C2778712684 @default.
• W2894841092 hasConcept C2778961482 @default.
• W2894841092 hasConcept C2779329299 @default.
• W2894841092 hasConcept C2780915607 @default.
• W2894841092 hasConcept C54355233 @default.
• W2894841092 hasConcept C62478195 @default.
• W2894841092 hasConcept C66332042 @default.
• W2894841092 hasConcept C83330619 @default.
• W2894841092 hasConcept C86803240 @default.
• W2894841092 hasConcept C87073359 @default.
• W2894841092 hasConcept C95444343 @default.
• W2894841092 hasConceptScore W2894841092C104317684 @default.
• W2894841092 hasConceptScore W2894841092C105702510 @default.
• W2894841092 hasConceptScore W2894841092C107459253 @default.
• W2894841092 hasConceptScore W2894841092C129536746 @default.
• W2894841092 hasConceptScore W2894841092C137620995 @default.
• W2894841092 hasConceptScore W2894841092C145103041 @default.
• W2894841092 hasConceptScore W2894841092C161879069 @default.
• W2894841092 hasConceptScore W2894841092C18155467 @default.
• W2894841092 hasConceptScore W2894841092C193252679 @default.
• W2894841092 hasConceptScore W2894841092C196843134 @default.

• next