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- W2894841535 abstract "La colitis ulcerosa es una enfermedad crónica del tracto digestivo, y hasta el 20-30% de los pacientes sufren un brote grave durante su evolución. Aunque existen guías nacionales e internacionales sobre el tratamiento de la colitis ulcerosa aguda grave, desconocemos cómo se manejan en la práctica clínica estos pacientes en nuestro medio. Realizamos una encuesta electrónica y anónima entre los miembros del Grupo Español de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa (GETECCU), compuesta por 51 preguntas con respuestas predefinidas. Participaron 164 miembros (20%), en su mayoría especialistas de aparato digestivo (95%). El 59% trabajaban en hospitales terciarios, atendiendo a una mediana de 5 pacientes al año (RIC: 3-8) con un brote grave de colitis ulcerosa. El 86% realizan un estudio endoscópico rutinario, habitualmente al ingreso (62%). El corticoide más empleado es la metilprednisolona, habitualmente a una dosis de 60 mg/día, y se evalúa su respuesta pasados 3 días (mediana, RIC: 3-5). El tratamiento de rescate usado con más frecuencia es infliximab, tanto en pacientes naïve como refractarios a tiopurinas. El 55% han indicado en alguna ocasión una dosis de infliximab mayor de 5 mg/kg durante la inducción, y el 73% han adelantado alguna de las sucesivas infusiones. El manejo de la colitis ulcerosa aguda grave en nuestro entorno se ajusta en general a las recomendaciones de tratamiento actuales. El tratamiento de rescate más frecuentemente prescrito es el infliximab, y no es excepcional el empleo de pautas intensificadas o aceleradas de este biológico. Ulcerative colitis (UC) is a chronic disease of the digestive tract and up to 20-30% of UC patients may suffer a severe flare-up during the course of the disease. Although there are national and international recommendations about its clinical management, there is not enough information about the treatment of acute severe UC in clinical practice. An electronic and anonymous survey with 51 multiple-choice questions was performed among all the members of the Spanish Crohn's Disease and Ulcerative Colitis Working Group (GETECCU). Out of the 164 responders (20%), most were gastroenterologists (95%), with 59% from tertiary hospitals treating a median of 5 patients per year (IQR: 3-8) with a severe flare-up of ulcerative colitis. An endoscopic examination was routinely performed in 86% of patients (62% at admission). The most commonly used corticosteroid was methylprednisolone, usually at a dose of 60 mg/day, and its response was assessed after a median of 3 days (IQR: 3-5). Both in thiopurine-naïve and thiopurine-refractory patients, infliximab was the drug most frequently prescribed as rescue therapy. Half of responders (55%) had ever prescribed a first dose of infliximab higher than 5 mg/kg, and a higher proportion (73%) had ever prescribed an earlier dose of infliximab in the second or third infusion. Acute severe UC is generally managed according to current treatment guidelines in our setting. The rescue therapy most commonly prescribed is infliximab, and the use of intensified or accelerated regimens with this biological drug is not unusual." @default.
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- W2894841535 date "2019-02-01" @default.
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- W2894841535 title "Manejo de la colitis ulcerosa aguda grave en España: Resultados de una encuesta sobre práctica clínica" @default.
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- W2894841535 doi "https://doi.org/10.1016/j.gastrohep.2018.09.002" @default.
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